| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Prouroguanylin (PUG) is precursor of uroguanylin that is peptide hormone. X-ray crystal structure of PUG has been determined at high resolution. In the folding process of PUG, the structure suggests that not only interactions between proregion and peptide region in the PUG that has correct folding but also those in the folding intermediates are very important. Furthermore, kinetic analysis of a folding process of PUG has been performed. It is elucidated that two folding intermediate structures are important in the folding process. In addition, behaviors of β-amyloid precursor protein in the solution were analyzed by CD, DSC and light scattering.
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