Analysis of regulatory mechanism of extracellular signal by endocytosis
| Project/Area Number |
19570120
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional biochemistry
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
TOSHIMA Jiro Tokyo University of Science, 基礎工学部・生物工学科, 講師 (00333831)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | エンドサイトーシス / アクチン / シグナル伝逹 / 癌 / クラスリン / シグナル伝達 |
|---|
| Research Abstract |
Endocytic internalization of receptor plays a critical role in down-regulation of receptor-mediated signaling, such as cell growth and differentiation. Here we identify recruitment of receptors to pre-existing clathrin-coated pits as a key step regulated by receptor phosphorylation and subsequent ubiquitination upon ligand binding.
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Report
(4 results)
Research Products
(16 results)
