| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Research Abstract |
The wide-angle X-ray scattering using the third generation synchrotron radiation source is a promising and powerful method elucidating in-situ hierarchical structures of proteins at those functional states. By the excution of this study aimed for the establishment of the solution X-ray wide-angle scattering, we can get scattering data with high statistics precision while avoiding radiation damage, and we clarified the relation between hydration shell and structural transition of a protein, the all processes of nucleation / growth in the amyloid metastasis, the change of dynamics of a protein induced by the amyloid transition (α-to-cross-β).We published the aobve results of this project in 11 full articles in academic journals and in 23 papers at overseas international conferences and at domestic academic society meetings.
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