| Project/Area Number |
19570161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
UESONO Yukifumi The University of Tokyo, 大学院・理学系研究科, 助教 (30251408)
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| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Yoshiko 東京大学, 大学院・理学系研究科, 准教授 (00138124)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 高浸透圧 / グルコース飢餓 / アクチン / 蛋白質合成 / 局所麻酔剤 / 抗精神病薬 / 両親媒性 / 酵母 / 出芽酵母 / ストレス応答 / アクチン骨格 / 翻訳開始 / 界面活性剤 |
|---|
| Research Abstract |
Local anesthetics and antipsychotic phenothiazines cause rapid shutdowns of both actin polarization and translation initiation in yeast. Here we investigated the structure-activity relationship using a variety of amphiphiles. Structure of hydrophilic region, length of hydrophobic region, and structures of both regions were responsible for the shutdown pattern, potency, and safety, respectively. These results indicate that the yeast system can easily evaluate the clinical drugs, and provide structural basis for designing shutdown compounds.
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