Recombination-independent homologous chromosome pairing in fission yeast
| Project/Area Number |
19570173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Molecular biology
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| Research Institution | National Institute of Information and Communications Technology |
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Principal Investigator |
DING Daqiao National Institute of Information and Communications Technology, 未来ICT研究センターバイオICTグループ, 主任研究員 (50359080)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 相同染色体の対合 / 発生・分化 / 分子生物学 / 遺伝学 / Non-Coding RNA / 染色体 / 減数分裂 / 細胞生物学 / 微生物学 |
|---|
| Research Abstract |
Pairing of homologous chromosome is an essential step in meiosis that ensures effective homologous recombination and reductional segregation in meiotic division. However, no mechanisms for chromosome specific recognition have ever been found. Here we found a novel double stand break independent pairing site, the sme2 locus, on the chromosome II of S.pombe, which shows extraordinary high and stable pairing activity. The sme2 gene encodes a meiosis specific non-coding RNA ; expression of sme2 non-coding RNA is essential for the pairing activity.
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Report
(4 results)
Research Products
(38 results)
