| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
A small G protein, Rab, is a major protein family which controls membrane traffic in eucaryotes. There are more than 60 members of Rab in the human genome, however, the biological functions of these proteins are not well understood. To clarify the physiological roles of Rab proteins in the endocytic transport, we isolated deletion mutants of genes encoding Rabs and their cooperating proteins in C.elegans. We systematically performed endocytosis assays using these mutations and identified proteins involved in endocytic transport in the multicellular organism.
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