Regulation of cell polarization by RAPL-Mst1 signaling

• Project/Area Number: 19570188
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: Kansai Medical University
• Principal Investigator: KATAGIRI Koko Kansai Medical University, 医学部, 准教授 (00322157)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 細胞内・細胞間情報伝達 / インテグリン / 接着 / 遊走 / PAPL / Mst1 / 小胞輸送 / RAPL

Research Abstract

免疫細胞の活発な生体内移動の基盤であるインテグリンを介する接着および遊走を制御する低分子量Gタンパク質Rap1会合分子RAPLの下流で、Mst1が細胞極性の形成に重要な役割を果たすことを見出した。Mst1のノックアウトマウスを作製し、免疫細胞の動態への影響をin vitro及びin vivoで定量解析し、Mst1がケモカインを介する極性形成や遊走に重要な働きをすることを明かにした。

Research Products

• [Journal Article] Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes (2009)
  • Author(s): K.Katagiri , T. Katakai , Y. Ebisuno , Y. Ueda, T. Okada, T. Kinashi
  • Journal Title: EMBO J. 6 Pages: 1319-1331
  • Peer Reviewed
• [Journal Article] Organizer-like reticular stromal cell layer common adult secondary lymphoid organs (2008)
  • Author(s): T. Katakai , H. Suto, M. Sugai, H. Gonda, A.Togawa , S. Suematsu, Y. Ebisuno, K. Katagiri, T. Kinashi, A. Shimizu
  • Journal Title: J.Immunol. 181 Pages: 6189-6200
  • Peer Reviewed
• [Journal Article] Organizer-like reticular stromal cell layer common adult secondary lymphoid organs. (2008)
  • Author(s): Katakai T, Suto H, Sugai M, Gonda H, Togawa A, Sumeatsu S, Ebisuno Y, Katagiri K, Kinashi T, Shimizu A.
  • Journal Title: J. Immunol. 81 Pages: 6189-6200
  • Peer Reviewed
• [Journal Article] The M-Ras-RA-GEF2-Rap1 pathway nediates tumor necrosis factor-α-dependent regulation of integrin activation in splenocytes (2007)
  • Author(s): Katagiri K
  • Journal Title: MCB 18 Pages: 2949-59
  • Peer Reviewed
• [Journal Article] Mst1 controls lymphocyte trafficking and interstitial motility with in lymph nodes.
  • Author(s): Katagiri, K, Katakai T, Ebisuno Y, Ueda Y, Okada T, Kinashi T.
  • Journal Title: EMBO J (In press)
  • Peer Reviewed
• [Presentation] Mst1 controls lymphocyte trafficking and interstitial motility within lymph nodes (2008)
  • Author(s): 片桐 晃子, 他
  • Organizer: 日本免疫学会
  • Place of Presentation: 京都
  • Year and Date: 2008-12-01
• [Presentation] Mst1 controls lymphocyte trafficking and interstitial motility with in lymph nodes. (2008)
  • Author(s): 片桐晃子
  • Organizer: 日本免疫学会
  • Place of Presentation: 京都国際会議場
  • Year and Date: 2008-12-01