| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We studied the molecular mechanisms in cell cycle and cell differentiation with the efficient bio-imaging system of the translucent blastomeres of the frog, Xenopus laevis. The interactions of molecules necessary for DNA synthesis, such as DNA polymerase and cdc 45, was clarified with FRET methods. we found that the decrease in protein synthesis during MBT determined the onset of cell cycle elongation followed by cell differentiation. In addition, we investigated the role of Ca ions in the regulation of cell cycle and cell differentiation during early embryonic development.
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