Roles of Tbx22 during early stage of secondary palate development.
| Project/Area Number |
19570213
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
WADA Naoyuki Kawasaki Medical School, 医学部, 助教 (50267449)
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| Co-Investigator(Kenkyū-buntansha) |
NOHNO Tsutomu 川崎医科大学, 医学部, 教授 (20098619)
NISHIMATSU Shin-ichiro 川崎医科大学, 医学部, 講師 (20222185)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 顎顔面形成 / 二次口蓋 / 舌 / Tbx22 / BMP / 顎顔面発生 / 口蓋板 / 舌形成 / 遺伝子発現抑制 / Noggin |
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| Research Abstract |
In this project, we focused on the developmental process of the secondary palate and tongue in chick embryo, and analyzed the expression and function of Tbx22, which is involved in X-linked cleft palate and ankyloglossia in human. Expression of Tbx22 is observed in the oral side of the maxillary process where the palatal shelf is emerged later, and in the bottom region of the tongue. The expression is regulated by BMP signaling. Misexpression of Tbx22 suppressed proliferation of cells in the facial processes, and inhibited osteogenesis of the cells, suggesting the suppressive role of Tbx22 on the formation of the secondary palate and tongue.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development.2009
Author(s)
Suzuki, D., Yamada, A., Amano, T., Yasuhara, R., Kimura, A., Sakahara, M., Tsumaki, N., Takeda, S., Tamura, M., Nakamura, M., Wada, N., Nohno, T., Shiroishi, T., Aiba, A., Kamijo, R.
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Journal Title
Dev. Biol. 335
Pages: 396-406
Related Report
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[Journal Article] 17β-estradiol inhibits chondrogenesis in the skull development of zebrafish embryos.2009
Author(s)
Fushimi, S., Wada, N., Nohno, T., Tomita, M., Saijoh, K., Sunami, S., Katsuyama, H.
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Journal Title
Aqua. Toxicol. 95
Pages: 292-298
Related Report
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[Journal Article] Nuclear localization of beta-catenin involved in precancerous change inoral leukoplakia2007
Author(s)
Ishida, K., Ito, S., Wada, N., Deguchi, H., Hata, T., Hosoda, M., Nohno, T.
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Journal Title
Molecular Cancer 9
Pages: 62-68
Related Report
Peer Reviewed
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