The molecular analysis of the formation of anterior -posterior axis by Cdx-Hox code

• Project/Area Number: 19570215
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Developmental biology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: SHIMIZU Takashi The Institute of Physical and Chemical Research, 体軸形成研究チーム, 研究員 (50324760)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 細胞分化 / cdx / Hox / FGF / Wnt / レチノイン酸 / 菱脳 / 小脳 / 神経 / Fgf

Research Abstract

生物の発生過程においては、同じ遺伝子経路が、胚体のいろいろな部位で異なった組織の形成に関与している。ゼブラフィッシュの神経系においては、Cdx-後方Hox遺伝子経路によって後方脊髄が作られる。また、Cdx遺伝子の発現しない前方領域においては、前方Hox遺伝子が菱脳を形成する。この過程において、FgfシグナルがCdx遺伝子の転写活性を制御して組織のシグナル伝達物質に対する応答性を変更していることが明らかとなった。

Research Products

• [Journal Article] Anatomy of zebrafish cerebellum and screen for mutations affecting its development (2009)
  • Author(s): 清水貴史(8名中3番目)
  • Journal Title: Developmental Biology (印刷中) Pages: 0-0
  • Peer Reviewed
• [Journal Article] Initial specification of the epibranchial placode in zebrafish embryos depends on the fibroblast growth factor signal (2007)
  • Author(s): 清水貴史(6名中3番目)
  • Journal Title: Developmental Dynamics 236 Pages: 564-571
  • Peer Reviewed
• [Journal Article] Initial specification of the epibranchial placode in zebrafish embryos depend on the fribroblast growth factor signal (2007)
  • Author(s): Nikaidao M., et. al.
  • Journal Title: Developmental Dynamics 236 Pages: 564-571
  • Peer Reviewed
• [Presentation] Genetic and histological analysis cerebellar neurogenesis (2008)
  • Author(s): 可児修一
  • Organizer: 8^<th> International Conference on Zebrafish Development and Genetics
  • Place of Presentation: マディソン、ウィスコンシン、アメリカ
• [Presentation] Genetic and Histological Analysis of Cerebellar Neurogenesis (2008)
  • Author(s): S. Kani, et al.
  • Organizer: 8^<th> International Conference on Zebrafish Development and Genetics
  • Place of Presentation: Madison, UAS
• [Presentation] Anterior-posterior patterning of neural tissue by fgfs, retinoic acid and cdx-hox codes (2007)
  • Author(s): 清水貴史
  • Organizer: 5^<th> European zebrafish genetic and Development meeting
  • Place of Presentation: アムステルダム、オランダ
• [Presentation] Anterior-posterior patterning of neural tissue by fgfs,retinoic acid and cdx-hox codes (2007)
  • Author(s): Shimizu T., et. al.
  • Organizer: 5^<th> European zebrafish genetic and development meeting
  • Place of Presentation: Amsterdam,Netherland
• [Remarks] ホームページ
  • URL: http://www.cdb.riken.go.jp/vaf/index.html
• [Remarks]
  • URL: http://www.cdb.riken.go.jp/vaf/index.html