Functional analysis of newly acquired genes that directed the evolution of chordates.
| Project/Area Number |
19570220
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Evolutionary biology
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| Research Institution | Kochi University |
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Principal Investigator |
FUJIWARA Shigeki Kochi University, 教育研究部自然科学系, 教授 (40229068)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | レチノイン酸 / 発生・分化 / 脊索動物 / 進化 / 遺伝子 / Hox / Nodal / 遺伝子発現調節 / レチノイン酸受容体 / レチノイン酸合成酵素 |
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| Research Abstract |
I analyzed the function of genes that were involved in the establishment of the chordate-specific body plan. Retinoic acid has been thought to function only in vertebrate embryos. In the present study, I demonstrated that retinoic acid contributed to organogenesis in the ascidian embryo, through the activation of the Hox1 gene. I also demonstrated that the growth factor, Nodal, was required for morphogenesis of the dorsal neural tube, which was a chordate-specific feature. The transcription factor, Cdx, was revealed to mediatethe Nodal signal and regulates neural tube formation.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] Gene expresion profile during the life cycle of the urochordate Ciona intestinalis2007
Author(s)
Azumi, K., Sabau, S.V., Fujie, M., Usami, T., Koyanagi, R., Kawashima, T., Fujiwara, S., Ogasawara, M., Satake, M., Nonaka, M., Wang, H-G., Satou, Y., Satoh, N
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Journal Title
Dev. Biol vol.308
Pages: 572-582
Related Report
Peer Reviewed
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