Regulation mechanism of intracellular coenzyme A by pantothenate kinase in Archaea
| Project/Area Number |
19580079
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied microbiology
|
|---|
| Research Institution | Ibaraki University |
|---|
Principal Investigator |
CHOHNAN Shigeru Ibaraki University, 農学部, 准教授 (70312775)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | パントテン酸キナーゼ / 古細菌 / コエンザイムA |
|---|
| Research Abstract |
A gene encoding a pantothenate kinase (CoaA) which is a key enzyme in coenzyme A biosynthetic pathway has been identified in a thermoacidophilic archaeon. The archaeal CoaA belongs to a prokaryotic type I CoaA and is not governed by feedback inhibition by CoA and its thioesters, although prokaryotic type I CoaAs are generally inhibited by the CoA species. Therefore, CoA biosynthetic pathways in the archaea belonging to the order Thermoplasmatales which has the type I CoaA are not regulated at CoaA step.
|
Report
(4 results)
Research Products
(9 results)
