Chemical Biology of Golgi Membrane Dynamics

• Project/Area Number: 19580098
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied microbiology
• Research Institution: Hosei University
• Principal Investigator: TAKATSUKI Akira Hosei University, 生命科学部, 教授 (80011972)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ゴルジ / 抗生物質 / ケミカルバイオロジー / 中心体 / 微小管 / 膜ダイナミクス / ゴルジ装置 / ブレフェルジンA / 膜構造体 / ヌクリエーション / 生理活性物質 / 生体膜 / ノコダゾール / 細胞骨格 / 細胞・組織 / 生理活性 / ブレフェルジン A

Research Abstract

The Golgi maintains its characteristic structure by a dynamic equilibrium manner, but this mechanism remains to be clarified. Chemicals affecting Golgi membrane dynamics were found at a relatively high ratio among those known to affect transition to mitotic phase of cell cycle and induce apoptosis. Results indicating that they act on the centrosome suggest that the centrosome plays important roles in the control of Golgi membrane dynamics.