Prevention and alleviation of lifestyle-related diseases with functional lipids

• Project/Area Number: 19580142
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: Saga University
• Principal Investigator: TERUYOSHI Yanagita Saga University, 農学部, 教授 (00093980)
• Co-Investigator(Kenkyū-buntansha): KOJI Nagao 佐賀大学, 農学部, 准教授 (10336109)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: マルチプルリスクファクター症候群 / 食環境 / アディポネクチン / MRF症候群 / Adiponectin

Research Abstract

これまでの研究により、脂肪組織から分泌されるアディポサイトカインが、マルチプルリスクファクター症候群の主要病態である脂肪肝やインスリン抵抗性の発症と改善に深く関わっていることが明らかとなった。そこで本研究では、肥満・糖尿病モデル動物を用いた病態生理学的検討により食環境との関係を評価した。その結果、特にアディポネクチンの血中濃度を食環境(食事性insulin sensitizer であるドコサヘキサエン酸を構成脂質として含む海洋資源由来フォスファチジルコリンや大豆由来ホスファチジルイノシトール)で制御することがマルチプルリスクファクター症候群の発症予防・改善に有効であることが示された。

Research Products

• [Journal Article] Effect of dietary phosphatidylinositol on cholesterol metabolism in Zucker(fa/fa) rats (2009)
  • Author(s): B. Shirouchi, K. Nagao, K. Furuya, N. Inoue, M. Inafuku, M. Nasu, K. Otsubo, S. Koga, H. Matsumoto, T. Yanagita
  • Journal Title: J. Oleo Sci. 58 Pages: 111-115
  • NAID: 130000437030
  • Peer Reviewed
• [Journal Article] Effect of Dietary Phosphatidylinositol on Cholesterol Metabolism in Zucker (fa/fa) Rats. (2009)
  • Author(s): B. Shirouchi, K. Nagao, K. Furuya, N. Inoue, M. Inafuku, M. Nasu, K. Otsubo, S. Koga, H. Matsumoto, T. Yanagita
  • Journal Title: J. Oleo Sci. 58 Pages: 111-115
  • NAID: 130000437030
  • Peer Reviewed
• [Journal Article] Effect of leptin infusion on insulin sensitivity and lipid metabolism in diet-induced lipodystrophy model mice (2008)
  • Author(s): K. Nagao, N. Inoue , Y. Ujino, K. Higa, B. Shirouchi, Y. M. Wang, T. Yanagita
  • Journal Title: Lipids in Health and Disease 7・8 Pages: 1-8
  • NAID: 120006534437
  • Peer Reviewed
• [Journal Article] Dietary phosphatidylinositol prevents the development of nonalcoholic fatty liver disease in Zucker(fa/fa) rats (2008)
  • Author(s): B. Shirouchi, K. Nagao, N. Inoue, K. Furuya, S. Koga, H. Matsumoto, T. Yanagita
  • Journal Title: J. Agric. Food Chem. 56 Pages: 2375-2379
  • Peer Reviewed
• [Journal Article] Functional lipids and prevention of metabolic syndrome (2008)
  • Author(s): T. Yanagita, K. Nagao
  • Journal Title: Asia Pac J. Clin. Nutr. 17 Pages: 181-191
  • NAID: 130005068515
  • Peer Reviewed
• [Journal Article] Bioactive lipids in metabolic syndrome (2008)
  • Author(s): K. Nagao, T. Yanagita
  • Journal Title: 47 Pages: 127-146
  • Peer Reviewed
• [Journal Article] Functional lipids and prevention of metabolic syndrome. (2008)
  • Author(s): T. Yanasita, K. Nagao
  • Journal Title: Asia Pac J. Clin. Nutr. 17 Pages: 181-191
• [Journal Article] Dietary phosphatidylinositol prevents the development of nonalcoholic fatty liver disease in Zucker (fa/fa) rats. (2008)
  • Author(s): B. Shirouchi, K. Nagao, N. Inoue, K. Furuya, S. Koga, H. Matsumoto, T. Yanagita
  • Journal Title: J. Agric. Food Chem. 56 Pages: 2375-2379
  • Peer Reviewed
• [Journal Article] Effect of leptin infusion on insulin sensitivity and lipid metabolism in diet-induced lipodystrophy model mice (2008)
  • Author(s): K.Nagao, N.Inoue, Y.Ujino, K.Higa, B.Shirouchi, Y.M.Wang, T.Yanagita
  • Journal Title: Lipids in Health and Disease 7・8 Pages: 1-8
  • NAID: 120006534437
  • Peer Reviewed
• [Journal Article] Effect of dietary omega3 phosphatidlycholine on obesity-related disorders in obese Otsuka Long-Evans Tokushima fatty rats (2007)
  • Author(s): B. Shirouchi, K. Nagao, N. Inoue, T. Ohkubo, H. Hibino, T. Yanagita
  • Journal Title: J. Agric. Food Chem. 55 Pages: 7170-7176
  • Peer Reviewed
• [Journal Article] Effect of dietary omega3 phosphatidlycholine on obesity-related disorders in obese Otsuka Long-Evans Tokushima fatty rats. (2007)
  • Author(s): B.Shirouchi, K.Nagao, N.Inoue, T.Ohkubo, H.Hibino, T.Yanagita
  • Journal Title: Journal of Agricultural and Food Chemistry 55・17
  • Peer Reviewed
• [Presentation] Physiological function of phosphatidylinositol. (2008)
  • Author(s): T. Yanagita, B. Shirouchi, K. Nagao, S. Koga, H. Matsumoto, K. Otsubo
  • Organizer: 4th International symposium on biocatalysis and biotechnology
  • Place of Presentation: Academia Sinicia (Taipei, Taiwan)
  • Year and Date: 2008-11-20
• [Presentation] Physiological function of phosphatidylinositol (2008)
  • Author(s): T. Yanagita, B. Shirouchi, K. Nagao, S. Koga, H. Matsumoto, K. Otsubo
  • Organizer: 4th International symposium on biocatalysis and biotechnology
  • Place of Presentation: Taipei(Taiwan)
• [Presentation] Food factors and the prevention of chronic diseases. (2007)
  • Author(s): T.Yanagita, K.Nagao
  • Organizer: 98^<th> American oil chemist' society annual meeting & expo
  • Place of Presentation: ケベック国際会議場(カナダ)
  • Year and Date: 2007-05-14
• [Presentation] Food factors and the prevention of chronic diseases (2007)
  • Author(s): T. Yanagita, K. Nagao
  • Organizer: 98^<th> American oil chemist' society annual meeting & expo
  • Place of Presentation: Quebec(Canada)
• [Book] Fatty Acids in Foods and Their Health Implications III (2008)
  • Author(s): Huang Y. S., T. Yanagita, K. Nagao, K. Koba
  • Publisher: CRC Press
• [Book] Biocatalysis and Bioenerg (2008)
  • Author(s): T. Yanagita, K. Nagao
  • Publisher: John Wiley & Sons, Inc.
• [Book] Biocatalysis and Bioenergy (2008)
  • Author(s): T. Yanagita, K. Nagao
  • Total Pages: 607
  • Publisher: John Wiley & Sons, Inc.
• [Book] Fatty Acids in Foods and Their Health Implications III (2007)
  • Author(s): Huang Y.S., T. Yanagita, K. Nagao, K. Koba
  • Total Pages: 1281
  • Publisher: CRC press, USA
• [Patent(Industrial Property Rights)] アディポネクチン上昇剤 (2007)
  • Inventor(s): 柳田晃良、永尾晃治、古賀晋治、松本英之
  • Industrial Property Rights Holder: 佐賀大学、旭化成ファーマ(株)
  • Filing Date: 2007-02-02