An approach to improvement of fertility by elucidation of he genetic trait to affect on the liver function in high-producing dairy cow

• Project/Area Number: 19580320
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied animal science
• Research Institution: Obihiro University of Agriculture and Veterinary Medicine
• Principal Investigator: KAWASHIMA Chiho Obihiro University of Agriculture and Veterinary Medicine, 畜産学部, 助教 (20374770)
• Co-Investigator(Kenkyū-buntansha): MATSUI Motozumi 帯広畜産大学, 畜産学部, 准教授 (20374762) ; KIDA Katsuya 帯広畜産大学, 畜産学部, 准教授 (70419216) ; SHIMIZU Takashi 帯広畜産大学, 畜産学部, 准教授 (90375113) ; MIYAMOTO Akio 帯広畜産大学, 畜産学部, 教授 (10192767)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 繁殖 / 遺伝 / 繁殖学 / 遺伝学 / 栄養学 / 生理学 / 獣医学

Research Abstract

同じ飼養管理下で同じ乳量の高泌乳牛の中にも繁殖性や疾病発生が個体により異なることから、遺伝的要因が関与している可能性がある。そこで、分娩後の卵巣機能回復に強く関わっている肝臓でのIGF-1の産生や乳生産、成長を促す成長ホルモンの受容体(GHR)に牛で多型が確認されたことに注目し、GHR多型と分娩後の卵巣機能回復、泌乳および成長期の増体や代謝状態との関連性を解析した。その結果、GHR多型と成長や代謝状態との関係はみられなかったが、卵巣機能と泌乳に関連があることが示された。

Research Products

• [Journal Article] Evaluation of ovarian blood flow by colour Doppler ultrasound : Practical use for reproductive management in the cow (2009)
  • Author(s): Matsui M, Miyamoto A.
  • Journal Title: Vet J. 181(3) Pages: 232-240
  • Peer Reviewed
• [Journal Article] Relationship betweenplasma β-carotene concentrations during the peripartum period and ovulation in the first follicular wave postpartum in dairy cows (2009)
  • Author(s): Kawashima C, Kida K, Schweigert FJ, Miyamoto A.
  • Journal Title: Anim Reprod Sci. 111 Pages: 105-111
  • Peer Reviewed
• [Journal Article] Relationship between plasma β-carotene concentrations during the peripartum period and ovulation in the first follicular wave postpartum in dairv cows (2009)
  • Author(s): Kawashima C.
  • Journal Title: Animal Reproduction Science 111(1) Pages: 105-111
  • Peer Reviewed
• [Journal Article] Evaluation of ovarian blood flow by colour Doppler ultrasound : Practical use for reproductive management in the cow (2009)
  • Author(s): Matsui M.
  • Journal Title: Veterinary Journal (in press)
  • Peer Reviewed
• [Journal Article] The absence of corpus luteum formation alters the endocrine profile and affects follicular development during the first follicular wave in cattle (2008)
  • Author(s): Hayashi KG, Matsui M, Shimizu T, Sudo N, Sato A, Shirasuna K, Tetsuka M, Kida K, Schams D, Miyamoto A.
  • Journal Title: Reproduction 136(6) Pages: 787-97
  • Peer Reviewed
• [Journal Article] Involvement of insulin and growth hormone(GH)during follicular development in the bovine ovary (2008)
  • Author(s): Shimizu T, Murayama C, Sudo N, Kawashima C, Tetsuka M, Miyamoto A.
  • Journal Title: Anim Reprod Sci 106(1-2) Pages: 143-152
  • Peer Reviewed
• [Journal Article] Involvement of insulin and growth hormone (GH) during follicular development in the bovine ovary (2008)
  • Author(s): Shimizu T.
  • Journal Title: Animal Reproduction Science 106(1-2) Pages: 143-152
  • Peer Reviewed
• [Journal Article] Induction of Ovulation with GnRH and PGF2α at Two Different Stages during the Early Postpartum Period in Dairy Cows : Ovarian Response and Changes in Hormone Concentrations (2007)
  • Author(s): Amaya Montoya C, Matsui M, Kawashima C, Hayashi K-G, Matsuda G, Kaneko E, Kida K, Miyamoto A, Miyake Y-I.
  • Journal Title: J.Reprod Dev. 53(4) Pages: 867-875
  • Peer Reviewed
• [Journal Article] A positive relationship between the first ovulation postpartum and the increasing rate of milk yield in the first part of lactation in high-producing dairy cows (2007)
  • Author(s): Kawashima C, Amaya Montoya C, Masuda Y, Kaneko E, Matsui M, Shimizu T, Matsunaga N, Kida K, Miyake Y-I, Suzuki M, Miyamoto A
  • Journal Title: J.Dairy Sci 90(5) Pages: 2279-2282
  • Peer Reviewed
• [Journal Article] Changes in plasma metabolic hormones concentrations during the ovarian cycles of Japanese Black and Holstein cattle. (2007)
  • Author(s): Kawashima C., et. al.
  • Journal Title: The journal of Reproduction and Development 53(2) Pages: 247-254
  • NAID: 10027327754
  • Peer Reviewed
• [Journal Article] A positive relationship between the first ovulation postpartum and the increasing rate of milk yield in the first part of lactation in high-producing dairy cows. (2007)
  • Author(s): Kawashima C., et. al.
  • Journal Title: The journal of Dairy Science 90(5) Pages: 2279-2282
  • Peer Reviewed
• [Journal Article] Induction of Ovulation with GnRH and PGF_<2α> at Two Different Stages during the Early Postpartum Period in Dairy Cows: Ovarian Response and Changes in Hormone Concentrations. (2007)
  • Author(s): Amaya Montoya C., et. al.
  • Journal Title: The journal of Reproduction and Development 53(4) Pages: 867-875
  • Peer Reviewed
• [Presentation] Effect of exogenous estradiol on plasma metabolic hormone concentrations in the female calf (2008)
  • Author(s): Kawashima C.
  • Organizer: 6th International Congress on Farm Animal Endocrinology
  • Place of Presentation: Roanoke, Virginia, USA
  • Year and Date: 2008-11-14
• [Presentation] 春機発動前の4ヶ月齢雌子牛における安息香酸エストラジオール製剤投与による血中代謝ホルモン濃度の動態 (2008)
  • Author(s): 川島千帆
  • Organizer: 日本繁殖生物学会
  • Place of Presentation: 九州大学
  • Year and Date: 2008-09-20
• [Presentation] 乳牛における分娩後の正常な卵巣周期回復時期と代謝因子との関係 (2007)
  • Author(s): 川島千帆
  • Organizer: 日本繁殖生物学会
  • Place of Presentation: 東京大学
  • Year and Date: 2007-10-20
• [Presentation] Logistic regression analysis for relationship between the timing of the resumption of normal ovarian cycles and metabolic status in postpartum dairy cows (2007)
  • Author(s): Kawashima C.
  • Organizer: Joint Annual Meeting ADSA-PSA-AMPA-ASAS
  • Place of Presentation: San Antonio, Texas, USA.
  • Year and Date: 2007-07-10
• [Presentation] Logistic regression analysis for relationship between the timing of the resumption of normal ovarian cycles and metabolic status in postpartum dairy cows. (2007)
  • Author(s): Kawashima C.
  • Organizer: Joint Annual Meeting ADSA-PSA-AMPA-ASAS
  • Place of Presentation: San Antonio, Texas, USA
  • Year and Date: 2007-07-10