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Clarification of new regulatory mechanisms of prolactin secretion by salsolinol in ruminants

Research Project

Project/Area Number 19580321
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied animal science
Research InstitutionIwate University

Principal Investigator

HASHIZUME Tsutomu  Iwate University, 農学部, 教授 (60124533)

Co-Investigator(Kenkyū-buntansha) KASUYA Etsuko  (独) 農業生物資源研究所, 研究員 (90355743)
KUWAYAMA Hideto  帯広畜産大学, 畜産学部, 准教授 (40125399)
SUZUKI Hiroyuki  弘前大学, 農学生命科学部, 教授 (50211313)
Co-Investigator(Renkei-kenkyūsha) KASUYA Etsuko  (独) 農業生物資源研究所, 研究員 (90355743)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Keywords生産機能制御 / サルソリノール / プロラクチン / 反芻家畜 / 下垂体 / 視床下部
Research Abstract

サルソリノール(Salsolinol : SAL)が反芻家畜のプロラクチン(PRL)分泌に及ぼす影響についてin vivo及びin vitroで検討した。その結果、SALは生体内で反芻家畜のPRL分泌に関係する生理的な放出因子であることが初めて明らかになった。またSALは主として視床下部を介してPRLを放出させること、さらに甲状腺刺激ホルモン放出ホルモンやドーパミンと相互的に作用してPRLの分泌を修飾することが明らかになった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (26 results)

All 2009 2008 2007 Other

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (14 results) Remarks (1 results)

  • [Journal Article] Characteristics of prolactin-releasing response to salsolinol(SAL)and thyrotropin-releasing hormone(TRH)in ruminants2009

    • Author(s)
      Hashizume T. -Kasuya E. -Nagy G. M
    • Journal Title

      Domestic Animal Endocrinology 36

      Pages: 99-104

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Methodology for the study of the hypothalamic-pituitary hormone secretion in cattle2009

    • Author(s)
      Hashizume T., Kasuya E
    • Journal Title

      Animal Science Journal 80

      Pages: 1-11

    • NAID

      10027885213

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Characteristics of prolactin-releasing response to salsolinol (SAL) and thyrotropin-releasing hormone (TRH) in ruminants2009

    • Author(s)
      Hashizume T., et.al.
    • Journal Title

      Domestic Animal Endocrinology 36

      Pages: 99-104

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Methodology for the study of the hypothalamic-pituitary hormone secretion in cattle2009

    • Author(s)
      Hashizume T. and Kasuya E.
    • Journal Title

      Animal Science Journal 80

      Pages: 1-11

    • NAID

      10027885213

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between salsolinol(SAL)and thyrotropin-releasing hormone(TRH)or dopamine(DA)on the secretion of prolactin in ruminants2008

    • Author(s)
      Hashizume T. -Kasuya E. -Kuwayama H. -Suzuki H. -Nagy G. M
    • Journal Title

      Domestic Animal Endocrinology 34

      Pages: 327-332

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Salsolinol is present in the bovine posterior pituitary gland and stimulates the release of prolactin both in vivo and in vitro in ruminants2008

    • Author(s)
      Hashizume T. -Kasuya E. -Nagy G. M
    • Journal Title

      Domestic Animal Endocrinology 34

      Pages: 146-152

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kisspeptin-10 stimulates the secretion of growth hormone and prolactin directly from cultured bovine anterior pituitary cells2008

    • Author(s)
      Kadokawa H., Suzuki S., Hashizume T
    • Journal Title

      Animal Reproduction Science 105

      Pages: 404-408

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct kisspeptin-10 stimulation on luteinizing hormone secretionfrom bovine and porcine anterior pituitary cells2008

    • Author(s)
      Suzuki S., Kadokawa H., Hashizume T
    • Journal Title

      Animal Reproduction Science 103

      Pages: 360-365

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction between salsolinol (SAL) and thyrotropin-releasing hormone (TRH) or dopamine (DA) on the secretion of prolactin in ruminants2008

    • Author(s)
      Hashizume T., et.al.
    • Journal Title

      Domestic Animal Endocrinology 34

      Pages: 327-332

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Salsolinol is present in the bovine posterior pituitary gland and stimulates the release of prolactin both in vivo and in vitro in ruminants.2008

    • Author(s)
      Hashizume T., et. al.
    • Journal Title

      Domestic Animal Endocrinology 34

      Pages: 146-152

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct kisspeptin-10 stimulation on luteinizing hormone secretionfrom bovine and porcine anterior pituitary cells.2008

    • Author(s)
      Suzuki S., Kadokawa H. and Hashizume T.
    • Journal Title

      Animal Reproduction Science 103

      Pages: 360-365

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Salsolinolの静脈及び脳室内投与はウシのプロラクチンを放出させる2009

    • Author(s)
      澤田建-粕谷悦子-橋爪力
    • Organizer
      日本畜産学会第110回大会
    • Place of Presentation
      藤沢・日本大学
    • Related Report
      2008 Final Research Report
  • [Presentation] ヤギにおけるプロラクチン分泌の季節変化に関する研究2009

    • Author(s)
      八重樫朋祥-橋爪力
    • Organizer
      日本畜産学会110回大会
    • Place of Presentation
      藤沢・日本大学
    • Related Report
      2008 Final Research Report
  • [Presentation] Salsolinolの静脈及び脳室内投与はウシのプロラクチンを放出させる2009

    • Author(s)
      澤田建-----橋爪力
    • Organizer
      日本畜産学会第110回大会
    • Place of Presentation
      藤沢、日本大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] ヤギにおけるプロラクチン分泌の季節変化に関する研究2009

    • Author(s)
      八重樫朋祥-----橋爪力
    • Organizer
      日本畜産学会第110回大会
    • Place of Presentation
      藤沢、日本大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] Salsolinol and prolactin secretion in cattle. 6th International Congress on Farm Animal2008

    • Author(s)
      Hashizume T. -Kasuya E. -Nagy G. M
    • Organizer
      Endocrinology
    • Place of Presentation
      Roanoke・USA
    • Related Report
      2008 Final Research Report
  • [Presentation] Salsolinolと反芻家畜のプロラクチン分泌に関する研究2008

    • Author(s)
      橋爪力-粕谷悦子
    • Organizer
      第101回日本繁殖生物学会
    • Place of Presentation
      福岡・九州大学
    • Related Report
      2008 Final Research Report
  • [Presentation] Characteristics of prolactin secretion by salsolinol in ruminants2008

    • Author(s)
      Hashizume T. -Kasuya E. -Nagy G. M
    • Organizer
      16th International Congress on Animal Reproduction
    • Place of Presentation
      Budapest・Hungary
    • Related Report
      2008 Final Research Report
  • [Presentation] Characteristics of prolactin secretion by salsolinol in ruminants2008

    • Author(s)
      Hashizume T., et.al.
    • Organizer
      16th International Congress on Animal Reproduction
    • Place of Presentation
      Budapest, Hungary
    • Related Report
      2008 Annual Research Report
  • [Presentation] Salsolinolと反芻家畜のプロラクチン分泌に関する研究2008

    • Author(s)
      橋爪力, ら
    • Organizer
      第101回日本繁殖生物学会
    • Place of Presentation
      福岡、九州大学
    • Related Report
      2008 Annual Research Report
  • [Presentation] Salsolinol and prolactin secretion in cattle2008

    • Author(s)
      Hashizume T., et.al.
    • Organizer
      6th International Congress on Farm Animal Endocrinology
    • Place of Presentation
      Roanoke, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] 反芻家畜におけるSalsolinolのプロラクチン分泌特性に関する研究2007

    • Author(s)
      橋爪力-粕谷悦子
    • Organizer
      第100回日本繁殖生物学会
    • Place of Presentation
      東京・東京大学
    • Related Report
      2008 Final Research Report
  • [Presentation] Salsolinolによる反芻家畜のプロラクチン分泌作用とTRH2007

    • Author(s)
      志田怜子-粕谷悦子-橋爪力
    • Organizer
      ドーパミンによる修飾
    • Place of Presentation
      東京・東京大学
    • Related Report
      2008 Final Research Report
  • [Presentation] 反芻家畜におけるSalsolinolのプロラクチン分泌特性に関する研究2007

    • Author(s)
      橋爪 力, ら
    • Organizer
      第100回日本繁殖生物学会
    • Place of Presentation
      東京,東京大学農学部
    • Related Report
      2007 Annual Research Report
  • [Presentation] Salsolinolによる反芻家畜プロラクチン分泌作用とTRH,ドーパミンによる修飾2007

    • Author(s)
      志田怜子.鈴木佐衣子.澤井 健・粕谷悦子・橋爪 力
    • Organizer
      第100回日本繁殖生物学会
    • Place of Presentation
      東京,東京大学農学部
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://sp2.cc.iwate-u.ac.jp/~hashi/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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