Fundamental study on the regulation system for indigenous bacteria colonies on the intestinal mucosa
Project/Area Number |
19580339
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Basic veterinary science/Basic zootechnical science
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Research Institution | Kobe University |
Principal Investigator |
KITAGAWA Hiroshi Kobe University, 大学院・農学研究科, 教授 (40125307)
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Co-Investigator(Kenkyū-buntansha) |
KIWANO Junichi 神戸大学, 大学院・農学研究科, 教授 (40127361)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
Keywords | アポトーシス / 消化管 / 常在細菌 / 生体防御 / パイエル板 / 抗菌物質 / 超微形態学 / 免疫組織化学 / M細胞 |
Research Abstract |
This study aimed to clarify the mechanisms of settlement and regulation of indigenous bacteria in the alimentary tract. As a result, this study clarified the apoptotic epithelial cells as the settlement places throughout the alimentary tract, the induction, execution and regulation mechanisms in the epithelial apoptosis, the possible epithelial ligands against some indigenous bacterial lectins, the elimination system against the attached indigenous bacteria by epithelial cells themselves, and the regulation system against the expansion of indigenous bacteria in the rat alimentary tract.
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Report
(4 results)
Research Products
(68 results)
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[Journal Article] Lectin histochemical detection of special sugars on the mucosal surfaces of the rat alimentary tract.2010
Author(s)
Yamamoto, K., Qi, W.-M., Yokoo, Y., Miyata, H., Udayanga, K.G.S., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science 72(n press)
NAID
Related Report
Peer Reviewed
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[Journal Article] Histoplanimetrical study on the relationship between cellular kinetics of epithelial cells and proliferation of indigenous bacteria in the rat colon.2009
Author(s)
Qi, W.-M., Yamamoto, K., Yokoo, Y., Miyata, H., Udayanga, K.G.S., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science 71
Pages: 745-752
NAID
Related Report
Peer Reviewed
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[Journal Article] Histoplasnimetrical study on the spatial relationship of indigenous bacteria and mucosal lymphatic follicles throughout alimentary tract of rat.2009
Author(s)
Yamamoto, K., Qi, W.-M., Yokoo, Y., Miyata, H., Udayanga, K.G.S., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science 71
Pages: 621-630
Related Report
Peer Reviewed
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[Journal Article] Histoplanimetrical study on the relationship between the cell kinetics of villous epithelial cells and the proliferation of indigenous bacteria in rat small intestine.2009
Author(s)
Qi, W.-M., Yamamoto, K., Yokoo, Y., Miyata, H., Inamoto, T., Udayanga, K.G., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science 71
Pages: 463-470
Related Report
Peer Reviewed
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[Journal Article] An immunohistochemical demonstration of the contribution of actin and myosin to physical elimination of adhered indigenous bacteria from mucous epithelial cells in Peyer's patches and intestinal villi of the rat jejunoileum.2008
Author(s)
Inamoto, T., Namba, M., Qi, W.-M., Yamamoto, K., Yokoo, Y., Miyata, H., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science 70
Pages: 1153-1158
Related Report
Peer Reviewed
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[Journal Article] Ultrastructural study on the epithelial responses against attachment of indigenous bacteria to epithelial membranes in Peyer's patches of rat small intestine.2008
Author(s)
Inamoto, T., Kawata, Y., Qi, W.-M., Yamamoto, K., Warita, K., Kawano, J., Yokoyama, T., Hoshi, N., Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science 70
Pages: 235-241
NAID
Related Report
Peer Reviewed
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[Journal Article] Immnohistochemical study on the delayed progression of epithelial apoptosis in follicle-associated epithelium of rat Peyer's Patch.2007
Author(s)
Onishi. S., Miyata, H., Inamoto, T., Qi, W.-M., Yamamoto, K., Yokoyama, T., Warita, K., Hoshi, N., Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science 69
Pages: 1123-1129
Related Report
Peer Reviewed
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[Journal Article] Ultrastructural study on the differentiation and the fate of M cells in follicle-associated epithelium of rat Peyer's Patch.2007
Author(s)
Onishi. S., Yokoyama, T., Chin, K., Yuji, M., Inamoto, T., Qi, W.-M., Warita, K., Hoshi, N., Kitagawa, H.
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Journal Title
Journal of Veterinary Medical Science 69
Pages: 501-508
NAID
Related Report
Peer Reviewed
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