| Project/Area Number |
19580339
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
|
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| Research Institution | Kobe University |
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Principal Investigator |
KITAGAWA Hiroshi Kobe University, 大学院・農学研究科, 教授 (40125307)
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| Co-Investigator(Kenkyū-buntansha) |
KIWANO Junichi 神戸大学, 大学院・農学研究科, 教授 (40127361)
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| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | アポトーシス / 消化管 / 常在細菌 / 生体防御 / パイエル板 / 抗菌物質 / 超微形態学 / 免疫組織化学 / M細胞 |
|---|
| Research Abstract |
This study aimed to clarify the mechanisms of settlement and regulation of indigenous bacteria in the alimentary tract. As a result, this study clarified the apoptotic epithelial cells as the settlement places throughout the alimentary tract, the induction, execution and regulation mechanisms in the epithelial apoptosis, the possible epithelial ligands against some indigenous bacterial lectins, the elimination system against the attached indigenous bacteria by epithelial cells themselves, and the regulation system against the expansion of indigenous bacteria in the rat alimentary tract.
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