| Project/Area Number |
19580355
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied veterinary science
|
|---|
| Research Institution | Yamaguchi University |
|---|
Principal Investigator |
SATO Hiroshi Yamaguchi University, 農学部, 准教授 (90211945)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Hideo 大分大学, 医学部, 教授 (00126442)
YOKOYAMA Mayumi 兵庫県立大学, 自然環境科学研究所, 准教授 (50344388)
本道 栄一 山口大学, 農学部, 准教授 (30271745)
|
|---|
| Project Period (FY) |
2007 – 2009
|
| Project Status |
Completed (Fiscal Year 2009)
|
| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | Strongyloides / zoonosis / diagnosis / pathogenecity / 糞線虫 / 人獣共通寄生虫症 / 分子系統進化 / 病原性 / 人獣共通寄生虫 / 種鑑別 / 糞線虫症 / 人獣共通感染症 / 幼虫移行症 / 動物由来感染症 / 診断技術 / 分子系統分類学 |
|---|
| Research Abstract |
Strongyloides spp. were obtained from a variety of wild animals, particularly primates in Japan and Africa. Genetic information such as 18S ribosomal RNA gene (rDNA) and the cox-1 region of mitochondrial DNA (COI) were collected. In this study, particular attention was paid to S. stercoralis and S. fuelleborni which are believed to infect both human beings and non-human primates. We found that four loop regions of the 18S rDNA of Strongyloides spp. are highly variable by species, and useful for species-differentiation. This technique together with genetic analyses of COI disclosed that S. fuelleborni kept by chimpanzees and a human patient working in the same region were identical, suggesting that human beings can be infected by S. fuelleborni maintained by wild non-human primates by chance. Simultaneously, distinct genetic backgrounds of morphologically identical S. fuelleborni distributed from Africa to Far East was indicated.
|
