Analysis of specific structure of Clostridium botulinum C・D mosaic neurotoxins and the development of their detection methods
| Project/Area Number |
19580360
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied veterinary science
|
|---|
| Research Institution | Osaka Prefecture University |
|---|
Principal Investigator |
KOZAKI Shunji Osaka Prefecture University, 生命環境科学研究科, 教授 (10109895)
|
|---|
| Project Period (FY) |
2007 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
|
|---|
| Keywords | ボツリヌス症 / ボツリヌス毒素 / 受容体 / 診断法 / イムノクロマト / ボツリヌス菌 / 神経毒素 / ガングリオシド |
|---|
| Research Abstract |
鳥類や家畜のボツリヌス症由来菌の産生する「C・Dモザイク」毒素の特徴について、毒性と抗原性状を典型的なC型およびD型神経毒素と比較することにより明らかにした。特に最近、本邦で散発的に発生している牛ボツリヌス症由来菌について疫学的解析を行うとともに毒素の免疫学的手法を用いた迅速な特異検出方法の確立を試みた。
|
Report
(3 results)
Research Products
(11 results)
-
[Journal Article] Identification of the receptor-binding sites in the carboxyl-terminal half of the heavy chain of botulinum neurotoxin types C and D2008
Author(s)
Tsukamoto, K., Kozai, Y., Ihara, H., Kohda, T., Mukamoto, M., Tsuji, T. and Kozaki, S.
-
Journal Title
Microb Pathog. 44
Pages: 484-493
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
