TRANSLATIONAL RESEARCH ON A MODEL OF GLYCAN CHAIN MODIFICATION OF ACUTE PHASE PROTEIN
| Project/Area Number |
19580370
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Yamaguchi University |
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Principal Investigator |
IWATA Hiroyuki Yamaguchi University, 農学部, 教授 (40193750)
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| Co-Investigator(Kenkyū-buntansha) |
MAEDA Ken 山口大学, 農学部, 准教授 (90284273)
KATO Hirotomo 山口大学, 農学部, 准教授 (00346579)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 急性期蛋白 / α1酸性糖蛋白 / 糖鎖修飾 / 腫瘍 / ウイルス |
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| Research Abstract |
難治性ウイルス感染症ならびに腫瘍における急性期糖蛋白変動解明と新規機能発見を目的に, 炎症に伴って上昇する血中糖蛋白(α1 酸性糖蛋白)を, ウシ血清およびネコ腹水から精製分離し, 各種疾患における変動, 糖鎖を解析し, 特にウシ白血病での血中上昇と糖鎖変動, ネココロナウイルス感染症(伝染性腹膜炎)での血中上昇がみられた.また, 実験動物の肝臓から本蛋白遺伝子のmRNA検出が可能となり, 基礎研究への応用が期待される.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Detection of multiple sapovirus genotypes and genogroups in oyster-associated outbreaks2009
Author(s)
Nakagawa-Okamoto R, Arita-Nishida T, Toda S, Kato H, Iwata H, Akiyama M, Nishio O, Kimura H, Noda M, Takeda N, Oka T
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Journal Title
Japanese Journal of Infectious Diseas 62
Pages: 63-66
Related Report
Peer Reviewed
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