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TRANSLATIONAL RESEARCH ON A MODEL OF GLYCAN CHAIN MODIFICATION OF ACUTE PHASE PROTEIN

Research Project

Project/Area Number 19580370
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Clinical veterinary science
Research InstitutionYamaguchi University

Principal Investigator

IWATA Hiroyuki  Yamaguchi University, 農学部, 教授 (40193750)

Co-Investigator(Kenkyū-buntansha) MAEDA Ken  山口大学, 農学部, 准教授 (90284273)
KATO Hirotomo  山口大学, 農学部, 准教授 (00346579)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords急性期蛋白 / α1酸性糖蛋白 / 糖鎖修飾 / 腫瘍 / ウイルス
Research Abstract

難治性ウイルス感染症ならびに腫瘍における急性期糖蛋白変動解明と新規機能発見を目的に, 炎症に伴って上昇する血中糖蛋白(α1 酸性糖蛋白)を, ウシ血清およびネコ腹水から精製分離し, 各種疾患における変動, 糖鎖を解析し, 特にウシ白血病での血中上昇と糖鎖変動, ネココロナウイルス感染症(伝染性腹膜炎)での血中上昇がみられた.また, 実験動物の肝臓から本蛋白遺伝子のmRNA検出が可能となり, 基礎研究への応用が期待される.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (22 results)

All 2009 2008 2007

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (6 results)

  • [Journal Article] Detection of multiple sapovirus genotypes and genogroups in oyster-associated outbreaks2009

    • Author(s)
      Nakagawa-Okamoto R, Arita-Nishida T, Toda S, Kato H, Iwata H, Akiyama M, Nishio O, Kimura H, Noda M, Takeda N, Oka T
    • Journal Title

      Japanese Journal of Infectious Diseas 62

      Pages: 63-66

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Detection of multiple sapovirus genotypes and genogroups in oyster-associated outbreaks.2009

    • Author(s)
      Nakagawa-Okamoto R, et al.
    • Journal Title

      Japanese Journal of Infectious Disease 62

      Pages: 63-66

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression changes induced by type IV allergyinducible chemicals in dendritic cells2008

    • Author(s)
      Tarama R, Kato H, Ishikawa Y, Miyaura H, Takeyoshi M, Iwata H
    • Journal Title

      Journal of Veterinary Medical Science 70

      Pages: 673-680

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Natural infection of Lutzomyia tortura with Leishmania (Viannia) naiffi in an Amazonian area of Ecuador2008

    • Author(s)
      Kato H, Gomez EA, Yamamoto Y, Calvopina M, Guevara AG, Marco JD, Barroso PA, Iwata H, Hashiguchi Y
    • Journal Title

      American Journal of Tropical Medical Hygiene 79

      Pages: 438-440

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] olecular typing of sand fly species (Diptera, Psychodidae, Phlebotominae) from areas endemic for Leishmaniasis in Ecuadorby PCR-RFLP of 18S ribosomal RNA gene2008

    • Author(s)
      Terayama Y, Kato H, Gomez EA, Uezato H, Calvopina M, Iwata H, Hashiguchi Y
    • Journal Title

      Journal of Veterinary Medical Science 70

      Pages: 907-913

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mass screening to incriminate sand fly vectors of Andean-type cutaneous leishmaniasis in Ecuador and Peru2008

    • Author(s)
      Kato H, Caceres AG, Gomez EA, Mimori T, Uezato H, Marco JD, Barroso PA, Iwata H, Hashiguchi Y
    • Journal Title

      American Journal of Tropical Medical Hygiene 79

      Pages: 719-721

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular mass screening to incriminate sand fly vectors of Andean-type cutaneous leishmaniasis in Ecuador and Peru.2008

    • Author(s)
      Kato H, et al.
    • Journal Title

      American Journal of Tropical Medical Hygiene 79

      Pages: 719-721

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular typing of sand fly species (Diptera, Psychodidae, Phlebotominae)from areas endemic for Leishmaniasis in Ecuadorby PCR-RFLP of 18S ribosomal RNA gene.2008

    • Author(s)
      Terayama Y, et al.
    • Journal Title

      Journal of Veterinary Medical Science 70

      Pages: 907-913

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Natural infection of Lutzomyia tortura with Leishmania(Viannia)naiffi in an Amazonian area of Ecuador2008

    • Author(s)
      Kato H, et al.
    • Journal Title

      American Journal of Tropical Medical Hygiene 79

      Pages: 438-440

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression changes induced by type IV allergy-inducible chemicals in dendritic cells.2008

    • Author(s)
      Tarama R, et al.
    • Journal Title

      Journal of Veterinary Medical Science 70

      Pages: 673-680

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Genotyping and quantitation of noroviruses in oysters from two distinct sea areas in Japan2007

    • Author(s)
      Nishida T, Nishio O, Kato M, Chuma T, Kato H, Iwata H, Kimura H
    • Journal Title

      Microbiology and Immunology 51

      Pages: 177-184

    • NAID

      10020281336

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of feline coronavirus type I and II infections by virus neutralization test2007

    • Author(s)
      Shiba N, Maeda K, Kato H, Mochizuki M, Iwata H
    • Journal Title

      Veterinary Microbiology 61

      Pages: 348-352

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a mass screening method of sand fly vectors for Leishmania infection by molecular biological methods2007

    • Author(s)
      Kato H, Uezato H, Gomez EA, Terayama Y, Calvopina M, Iwata H, Hashiguchi Y
    • Journal Title

      American Journal of Tropical Medical Hygiene 77

      Pages: 324-329

    • NAID

      120001671575

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Genotyping and quantitation of noroviruses in oysters from two distinct sea areas in Japan.2007

    • Author(s)
      Nishida T, et. al.
    • Journal Title

      Microbiology and Immunology 51

      Pages: 177-184

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of feline coronavirus type I and II infections by virus neutralization test.2007

    • Author(s)
      Shiba N, et. al.
    • Journal Title

      Veterinary Microbiology 61

      Pages: 348-352

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment of a mass screening method of sand fly vectors for Leishmania infection by molecular biological methods2007

    • Author(s)
      Kato H, et. al.
    • Journal Title

      American Journal of Tropical Medical Hygiene 77

      Pages: 324-329

    • NAID

      120001671575

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] FIP発症ネコ血清にのみ存在する感染増強機構2008

    • Author(s)
      寺田豊, 芝希望, 前田健, 水野拓也, 甲斐一成, 望月雅美, 加藤大智, 岩田祐之
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      宮崎市
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Lectin isolated from Momordica charantia seed is a B cell Activator2008

    • Author(s)
      黄莉, 足立匠, 清水佑也, 後藤義孝, 外山潤, 田中秀典, 明石良, 岩田祐之, 芳賀猛
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      宮崎市
    • Year and Date
      2008-09-25
    • Related Report
      2008 Final Research Report
  • [Presentation] Lectin isolated from Momordica charantia seed is a B cell activator2008

    • Author(s)
      黄 莉
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      宮崎市
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] IV型アレルギー誘発性化学物質によって樹状細胞に誘導される遺伝子変動の解析2007

    • Author(s)
      多良間理絵, 加藤大智, 石川陽一, 武吉正博, 岩田祐之
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      つくば市
    • Year and Date
      2007-04-04
    • Related Report
      2008 Final Research Report
  • [Presentation] ウイルス中和試験を用いたネココロナウイルス感染の血清疫学的解析2007

    • Author(s)
      芝希望, 前田健, 加藤大智, 望月雅美, 岩田祐之
    • Organizer
      第146回日本獣医学会学術集会
    • Place of Presentation
      つくば市
    • Year and Date
      2007-04-03
    • Related Report
      2008 Final Research Report
  • [Presentation] ウイルス中和試験を用いたネココロナウイルス感染の血清疫学的解析2007

    • Author(s)
      芝 希望 ほか
    • Organizer
      第143回日本獣医学会学術集会
    • Place of Presentation
      つくば市
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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