| Project/Area Number |
19580373
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Clinical veterinary science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
KAWATE Noritoshi Osaka Prefecture University, 生命環境科学研究科, 准教授 (80221901)
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| Co-Investigator(Kenkyū-buntansha) |
玉田 尋通 大阪府立大学, 生命環境科学研究科, 教授 (10155252)
稲葉 俊夫 大阪府立大学, 生命環境科学研究科, 教授 (00137241)
喜田 加世子 大阪府立大学, 生命環境科学研究科, 助教 (50405362)
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| Co-Investigator(Renkei-kenkyūsha) |
TAMADA Hiromichi 大阪府立大学, 生命環境科学研究科, 教授 (10155252)
INABA Toshio 大阪府立大学, 生命環境科学研究科, 教授 (00137241)
KIDA Kayoko 大阪府立大学, 生命環境科学研究科, 助教 (50405362)
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| Research Collaborator |
PATHIRANA Indunil Nishantha 大阪府立大学, 生命環境科学研究科, 大学院生
TANAKA Kakeru 大阪府立大学, 農学部・獣医学科, 学部生
ASHIDA Yukino 大阪府立大学, 農学部・獣医学科, 学部生
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 潜在精巣 / イヌ / エストロジェン受容体α遺伝子 / 一塩基多型(SNP) / ゲノムDNA / 培養精巣細胞 / テストステロン分泌 |
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| Research Abstract |
In the present study, in order to identify causative gene or marker gene for canine cryptorchidism, a part (9 single nucleotide polymorphisms in 70kb region from 3'terminal) of estrogen receptor・gene (ESR1) was examined in cryptorchid dogs of small breeds and compared with normal animals. As the results, no clear differences of the frequency of the single nucleotide polymorphisms were found in Miniature Duchshunds and Chihuahuas between cryptorchid and normal dogs. However, frequencies of the polymorphisms of cryptorchid dogs differed with normal animals although the examined number of affected dogs was small, and thus further studies are required to determine the associations between bilateral cryptorchidism and the polymorphism in ESR1.
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