Studies on the Molecular Mechanism of Species-specific Recognition in Biological Diversity
Project/Area Number |
19580395
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied molecular and cellular biology
|
Research Institution | Kyoto University |
Principal Investigator |
TANI Fumito Kyoto University, 地球環境学堂, 准教授 (70212040)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
Keywords | 分子情報 / ストレスタンパク質 / 多様性識別 / 種特異性 / 免疫生物学 / 生物種特異的 / 可変領域 / 膜受容体 / 自然免疫 / 制御性T細胞 / T細胞分化 / 非相同的塩基配列 / 光反応性架橋剤 / 抗原提示細胞 |
Research Abstract |
Murine lymphoid neoplastic P388D1 cells were found to have six receptor candidates with the molecular sizes in the range from 130 to 300kDa which discriminate species-specificity among the C-terminal variable regions of heat shock protein 70 (HSP70). We revealed that species-specific diversity contributes in the cell-surface presentation on murine LL/2 lung carcinoma upon non-lethal heat shock, in the binding to CD11b-, CD11c-, or NK1.1-positive innate immune cells, and also in the differentiation to regulatory T cells from nalve T cells.
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Report
(4 results)
Research Products
(26 results)