| Budget Amount *help |
¥4,090,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥690,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Research Abstract |
Abnormal vascular smooth muscle (VSM)contraction (vasospasm) is one of the crucial phenomena which cause cardiac angina and myocardial infarction. We previously found that sphingosylphosphorylcholine (SPC) as an upstream mediator for the abnormal pathway through the activation of Fyn, a member of Src family tyrosine kinase. The localization of Fyn in cholesterol-enriched membrane microdomain, lipid rafts, suggest the essential roles of membrane lipid rafts in abnormal contraction. Therefore, we investigated the relationship between lipid rafts and SPC-induced Ca^<2+>-sensitization of VSM. In addition we screened novel compounds which could inhibit SPC-induced Ca^<2+>-sensitization. Some newly found compounds would be the candidates for novel functional food for vasospasm.
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