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Molecular Structure Analysis on the Interactive Relations of Functionalized Compounds with NMR in Solution and Solid States

Research Project

Project/Area Number 19590002
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionChiba University

Principal Investigator

SEKI Hiroko  Chiba University, 分析センター, 准教授 (60114245)

Co-Investigator(Kenkyū-buntansha) KUMAMOTO Takuya  千葉大学, 大学院・薬学研究院, 准教授 (50292678)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords機能性化合物 / 固体NMR / 分子間相互作用 / CP-MAS / 水素結合 / 分子間相亙作用
Research Abstract

ビスグアニジン型化合物と各種酸性化合物との複合体を用い、単結晶X線解析や溶液・固体NMR を組み合わせた機能性化合物の分子間相互作用を含む構造解析を行った。ビスグアニジン-ヒ酸複合体の固体NMRは想定される本数よりも多いシグナルを示した。これは複合体中のグアニジン部位が非等価であるというX線解析の結果を反映したデータであり、固体NMRが分子間相互作用を持つ複合体の構造解析に有効な手段となる可能性を示した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (30 results)

All 2010 2009 2008 2007 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (12 results) Book (2 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] The Characterization of Various o-Bisguanidinobenzene-Benzoic Acid Complexes in Solid And in Solution States2010

    • Author(s)
      Kumamoto, T. Seki, H
    • Journal Title

      Heterocycles 80巻

    • NAID

      40016900107

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complexability of o-Bisguanidino- benzenes with Arsenic and Phosphoric Acids in Solution and Solid States,and the Potential Use of their Immobilized Derivatives as Solid Base Ligands for Metal Salts and Arsenic Acid2009

    • Author(s)
      Ito, T., Suda, K., Kumamoto, T., Nakanishi, W., Watanabe, T. Ishikawa, T. Seki, H. Kawahata, M. Yamaguchi, K. Ogura, Y. Kazuo T. Suzuki
    • Journal Title

      Molecular Diversity

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Semi-quantitative Approaches to the Coordination Ability of o-Bisguanidiniobenzenes with Metal Salts2009

    • Author(s)
      Suda, K., Saito, N., Kumamoto, T
    • Journal Title

      Heterocycles 77巻

      Pages: 375-387

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] NMR study on a novel mucin from jellyfish in natural abundance, qniumucin from Aurelia aurita2009

    • Author(s)
      Uzawa, J., Urai, M., Baba, T., Seki, H., Taniguchi, K., Ushida, K
    • Journal Title

      J.Nat.Prod. 72巻

      Pages: 818-823

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Complexability of o-Bisguanidinobenzenes with Arsenic and Phosphoric Acids in Solution and Solid States, and Potential use of their Immobilized Derivativesas Solid Base Ligands for Metal Salts and Arsenic Acid2009

    • Author(s)
      Ito, T.
    • Journal Title

      Molecular Diversity (accepted)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Semi-quantitative Approsches to the Coordination Ability of o-bisguanidiniobenzenes with Metal Salts2009

    • Author(s)
      Suda, K.
    • Journal Title

      Heterocycles 77

      Pages: 375-387

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Guanidine-Cata- lyzed Asymmetric Synthesis of 2,2-Disubstituted Chromane Skeletons by Intramolecular Oxa-Michael Addition2008

    • Author(s)
      Saito, N., Ryoda, A., Nakanishi, W., Kumamoto, T., Ishikawa, T
    • Journal Title

      Eur.J.Org.Chem

      Pages: 2759-2766

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Optical Resolution of(±)-1,2-Bis(2-methylphenyl)ethylene-1,2-diamine as a Chiral Framework for 2-Iminoimidazolidine with 2-Methylphenyl Pendant and the Guanidine-Catalyzed Asymmetric Michael Reaction of tert-Butyl Diphenyliminoacetate and Ethyl Acrylate2008

    • Author(s)
      Ryoda, A., Yajima, N., Haga, T., Kumamoto,T
    • Journal Title

      J.Org.Chem 73巻

      Pages: 133-141

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Guanidine-Catalyzed Asymmetric Synthesis of 2,2-Disubstituted Chromane Skeletons by Intramolecular Oxa-Michael Addition2008

    • Author(s)
      saito, N.
    • Journal Title

      Eur. J. Org. Chem.

      Pages: 2759-2766

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optical Resolution of (±)-1,2-Bis(2-methylpheny1)ethylene-1,2-diamine as a Chiral Framework for 2-Iminoimidazolidine with 2-Methylphenyl Pelldant and the Guanidme-Catalyzed Asymmethc Midhael Reaction of tert-Butl Dihenyliminoacetate and Ethyl Acrylate2008

    • Author(s)
      A.Ryoda
    • Journal Title

      J.Org.Chem 73

      Pages: 133-141

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ishikawa, Quantum-Chemical Study of 1,2-Bis-(dimethylethylene-guanidino) benzenes2007

    • Author(s)
      D. Margetic, W. Nakanishi, T. Kumamoto, T
    • Journal Title

      Heterocycles 71巻

      Pages: 2639-2658

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis of (±)-methyl-kinamycin C2007

    • Author(s)
      T. Kumamoto, Y. Kitani, H. Tsuchiya, K.Yamaguchi, H. Seki, T. Ishikawa
    • Journal Title

      Tetrahedron 63巻

      Pages: 5189-5199

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis of (±)-methyl-kinamyein C2007

    • Author(s)
      T.Kumamoto
    • Journal Title

      Tetrahedron 63

      Pages: 5189-5199

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantum-Chemical Study of 1,2-Bis(dimethylethylene-guanidino)benzenes2007

    • Author(s)
      D.Margetic
    • Journal Title

      Heterocycles 71

      Pages: 2639-2658

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] ポリマー固定化チロシン由来グアニジンの合成と不斉マイケル反応への適応2009

    • Author(s)
      平馬崇
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] アキラルグアニジンの不斉結晶化2009

    • Author(s)
      福隅正洋
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 分子ジッパーに基づくロイシン誘導体フィルムの特性とその応用2008

    • Author(s)
      吉田清香
    • Organizer
      第57回高分子討論会
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-24
    • Related Report
      2008 Final Research Report
  • [Presentation] ビスグアニジン型化合物の金属カチオンとの親和性:環境浄化試薬開発を指向した金属塩補足の評価2008

    • Author(s)
      関宏子
    • Organizer
      第75回日本分析化学会有機微量分析研究懇談会・第77回計測自動制御学会力学量計測部会・第25回合同シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2008-05-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] ポリマー固定化グアニジン触媒の開発2008

    • Author(s)
      平馬崇
    • Organizer
      第56回有機合成化学協会関東支部シンポジウム
    • Place of Presentation
      新潟
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] ビスグアニジン型化合物の金属カチオンとの親和性 : 環境浄化試薬開発を指向した金属塩補足の評価2008

    • Author(s)
      関宏子
    • Organizer
      第75回日本分析化学会有機微量分析研究懇談会・第77回計測自動制御学会力学量計測部会第・25回合同シンポジウム
    • Place of Presentation
      金沢
    • Related Report
      2008 Final Research Report
  • [Presentation] 水質浄化を指向したグアニジン型機能性触媒の開発2008

    • Author(s)
      須田幸司
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Related Report
      2008 Final Research Report
  • [Presentation] 水質浄化を指向したグアニジン型機能性触媒の開発:有機化学をベースとした環境問題への挑戦2007

    • Author(s)
      須田 幸司
    • Organizer
      第33回反応と合成の進歩シンポジウム
    • Place of Presentation
      長崎
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 光学活性グアニジンを用いる不斉マイケル反応2007

    • Author(s)
      熊本卓哉
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野
    • Related Report
      2008 Final Research Report 2007 Annual Research Report
  • [Presentation] 新規イメージングを目指した導電性ポリマー膜の重合・解重合・再重合 (Electropolymerization, depolymerization,and repolymerization of conducting polymer film and its application to novel imaging process)2007

    • Author(s)
      金商国
    • Organizer
      The 99th Annual Conference of the Imaging Society of Japan "Imaging Conference JAPAN 2007"
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] Enantioselective Michael Reactions Catalyzed by Chiral Guanidines2007

    • Author(s)
      熊本卓哉
    • Organizer
      International Conference on Asymmetric Organocatalysis
    • Place of Presentation
      大津
    • Related Report
      2008 Final Research Report
  • [Presentation] Enantioselective Midlael Reactions Catalyzed by Chiral Guanidines2007

    • Author(s)
      熊本 卓哉
    • Organizer
      International Conference on Asymmetric Organocatalysis
    • Place of Presentation
      大津
    • Related Report
      2007 Annual Research Report
  • [Book] John Wiley & Sons2009

    • Author(s)
      石川勉, 熊本卓哉
    • Total Pages
      326
    • Publisher
      Superbases for Organic Synthesis Guanidines, Amidines, Phosphazenes and Related Organocatalysts
    • Related Report
      2008 Final Research Report
  • [Book] Superbases for Organic Synthesis Guanidines, Amidines, Phosphazenes and Related Organocatalysts2009

    • Author(s)
      石川勉, 熊本卓哉
    • Total Pages
      326
    • Publisher
      John Wiley & Sons
    • Related Report
      2008 Annual Research Report
  • [Remarks] BGとヒ酸との相互作用を利用した水の浄化に関する研究が日本薬学会第128年会(2008年)のハイライトに採択(タイトル : 「環境問題への挑戦! 有機化学が飲み水をきれいにする?」)

    • Related Report
      2008 Final Research Report
  • [Patent(Industrial Property Rights)] グアニジン化合物及びグアニジン化合物のポリマー固定化複合体2008

    • Inventor(s)
      石川勉, 平馬崇, 熊本卓也
    • Industrial Property Rights Holder
      国立大学法人千葉大学
    • Filing Date
      2008-11-07
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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