Chemical syntheses of oligosaccharides to elucidate host-parasite interactions
| Project/Area Number |
19590011
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Keio University (2008-2009)
Kyoritsu University of Pharmacy (2007) |
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Principal Investigator |
HADA Noriyasu Keio University, 薬学部, 准教授 (70296531)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 糖鎖合成 / 宿主・寄生相互作用 / 糖脂質 / 糖タンパク質 / 寄生虫 / 糸状菌 / 糖化学 / 寄生・宿主相互作用 |
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| Research Abstract |
The oligosaccharide residues of glycoprotein and glycosphingolipids in mammalian tissues have been extensively studied for various biological recognition in recent years. In contrast, much less time has been devoted to structures of oligosaccharides from invertebrates that differ significantly from mammalian glycans. Due to these differences in the glycan structure we have been interested in the relationships between the structure and biological activity of oligosaccharides from invertebrate species, and in our continuing studies to elucidate the mechanism of host-parasite interaction. We carried out the synthesis of oligosaccharides from the helminth, Echinococcus multilocularis, Ascaris suum, Schistosoma mansoni and Zygomycetes species Mucor hiemalis, and got target oligosaccharides more than twenty kinds.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article]2009
Author(s)
羽田紀康, 竹田忠紘
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Journal Title
複合糖質の化学と最新応用技術 第6章 無脊椎動物由来糖脂質の合成(シーエムシー出版)
Pages: 162-170
Related Report
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