Serach for New Targeted Molecules of Cancer Using Pharmacophore Method.
| Project/Area Number |
19590023
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Meijo University |
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Principal Investigator |
ITO Chihiro Meijo University, 薬学部, 准教授 (60193497)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 天然資源 / がん標的分子 / ファーマコフォア検索 / アポトーシス誘導活性 / 発がんプロモーション抑制活性 / ヒスタミン放出抑制活性 / 抗酸化活性 / 抗炎症活性 / Clausena / γ-ラクトン / カルバゾールアルカロイド / HL-60 / かつお節 / Eurotium / 抗酸化物質 / auroglaucin / 米種麹 / pyranonigrin / 血管接着分子 / Citrus / natsudaidain / TNF-α / cyclooxygenase-2 / 発がんプモーション抑制活性 / ヒスタミン放出制活性 / シンナミルフェノール / フラノンクマリン / フェニルプロパノイド / フィトキノイド / 植物 |
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| Research Abstract |
The pharmacophore three-dimentional model was constructed on the basis of the most active flavonoid obtained from plant resources. The database searches using this model and the assay on the biological active compounds were repeated. Based on these experimental results, the better pharmacophore three-dimentional model was reconstructed. Some new information was obtained from the searches for bioactive compounds, too.
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Report
(4 results)
Research Products
(53 results)
