Development of a fat soluble signal molecule for cancer chemotherapy
| Project/Area Number |
19590027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
WADA Akimori Kobe Pharmaceutical University, 薬学部, 教授 (80158683)
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| Co-Investigator(Kenkyū-buntansha) |
OKITSU Takashi 神戸薬科大学, 薬学部, 助教 (50441209)
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| Co-Investigator(Renkei-kenkyūsha) |
OKANO Toshio 神戸薬科大学, 薬学部, 教授 (20131542)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 癌 / シグナル伝達 / 核内受容体 / 生理活性 / イソプレノイド / 脂溶性リガンド |
|---|
| Research Abstract |
As geranylgeranoic acid (GGA) was considered as an retinoic acid analog, various GGA analogs were efficiently synthesized and their biological activities were evaluated. The combination of conjugate polyene system and the position of methyl substituent played an important role in regulation of gene transcription and apoptosis-inducing activity in HL-60 cells. These high activities would be caused by high binding affinity to the receptors. The results provide useful information on the structure-activity relationship of GGA derivatives as mimic of acyclic retinoic acid analogs for the development of new drugs.
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Report
(4 results)
Research Products
(88 results)
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[Journal Article]2009
Author(s)
山野由美子
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Journal Title
カロテノイドの科学と最新応用技術(シーエムシー出版)
Pages: 38-48
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[Journal Article] Quantification of Fat-soluble Vitamins in Human Breast Milk by Liquid Chromatography-tandem Mass Spectrometory2007
Author(s)
M. Kamao, N. Tsugawa, Y. Suhara, A. Wada, T. Mori, K. Murata, R. Nishino, T. Ukita, K. Uenishi, K. Tanaka, T. Okano
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Journal Title
J. Chromatography B 859
Pages: 192-200
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