Development of metal complexes that specifically recognize both nucleobases and higher-order structures of nucleic acids, and their recognition mechanism
Project/Area Number |
19590038
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Physical pharmacy
|
Research Institution | Toyohashi University of Technology |
Principal Investigator |
KATSUYUKI Aoki Toyohashi University of Technology, 工学部, 教授 (30087514)
|
Co-Investigator(Kenkyū-buntansha) |
水野 彰 豊橋技術科学大学, 工学部, 教授 (20144199)
|
Co-Investigator(Renkei-kenkyūsha) |
藤澤 郁英 豊橋技術科学大学, 工学部, 助手 (80345959)
|
Project Period (FY) |
2007 – 2008
|
Project Status |
Completed (Fiscal Year 2008)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 核酸塩基 / 核酸高次構造 / 金属錯体 / 分子認識 / 配位子間相互作用 / 結晶構造 / ロジウムカルボキシラト錯体 / ロジウムアミダト錯体 / ロジウムアセタト錯体 / ロジウムアセタミダト錯体 |
Research Abstract |
核酸の塩基および高次構造を特異的に認識する金属錯体としてデザイン・合成した強固な八面体配位構造をもつジロジウム錯体を用いて, 核酸の塩基配列および高次構造が既知のDNAオリゴヌクレオチドあるいはDNAポリマーとの反応を行い, ジロジウム錯体が核酸塩基を特異的に認識すること, 一本鎖DNAおよび左巻二本鎖DNAと結合するが, 右巻二本鎖DNAと結合しないこと, この塩基および高次構造特異的認識が配位子間相互作用(水素結合, 静電的相互作用, 立体障害)に基づくことを明らかにした。
|
Report
(3 results)
Research Products
(5 results)
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[Journal Article] Metal ion interactions with nucleobases in the tripodal tris(2-aminoethyl)amine (tren) ligandsystem. Crystal structures of [Zn(tren)(adeninato)]. ClO_4, [Zn(tren)(adeninato)].ClO_4,[Ni(tren)(adeninato)(ClO_4)],[Zn(tren)(hypoxanthinato)]. ClO_4.H_2O, [{Cd(tren)}2(hypoxanthinato)].(ClO_4)3.0.5H_2O,[Ni(tren)(uracirato)(H_2O)].ClO_4.(0.5H_2O)_2, and [Cu(tren)(uracirato)]. ClO_4.0.5H_2O2009
Author(s)
M.A. Salam, H.Q. Yuan, T. Kikuchi, N. A. Prasad, I. Fujisawa, K. Aoki
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Journal Title
Inorg. Chim. Acta 362
Pages: 1158-1168
Related Report
Peer Reviewed
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[Journal Article] Metal ion interactions with nucleobases in the tripodal tris (2-aminiethyl) amine (tren) ligand-system. Crystal structures of [Zn(tren)(adeninato)]. ClO_4, [Zn(tren)(adeninato)]. ClO_4, [Ni(tren)(adeninato)(ClO_4)], [Zn(tren)(hypoxanthinato)]. ClO_4. H_2O, [{Cd(tren)}_2(hypoxanthinato)]. (ClO_4)_3. 0.5H_2O, [Ni(tren)(uracirato)(H_2O)]. ClO_4, (0.5H_2O)_2, and [Cu(tren)(uracirato)]. ClO_4, 0.5H_2O2009
Author(s)
M. A. Salam, H. Q. Yuan, T. Kikuchi, N. A. Prasad, I. Fujisawa, K. Aoki
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Journal Title
Inorg. Chim. Acta 362
Pages: 1158-1168
Related Report
Peer Reviewed
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