Development and application of sensors selective to biologically active substances
| Project/Area Number |
19590039
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Okayama University |
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Principal Investigator |
KATSU Takashi Okayama University, 大学院・医歯薬学総合研究科, 教授 (40112156)
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| Co-Investigator(Kenkyū-buntansha) |
KOMAGOE Keiko 岡山大学, 薬学部, 技術専門職員 (50437563)
美馬 伸治 熊本大学, 薬学部, 助教 (50398244)
増田 和文 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00243486)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | イオンセンサー / 酸素電極 / カフェイン / 活性酸素 / ポルフィリン / 膜電位 / 呼吸阻害 / 膜透過 / センサー / スーパーオキシドアニオン / 光不活性化 / 有機アンモニウムイオンセンサー / ヒドロキシルラジカル |
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| Research Abstract |
We developed new sensors selective to caffeine and reactive oxygen species such as hydroxyl radical and superoxide anion. We utilized a commercially available oxygen electrode to detect reactive oxygen species. Applications of sensors were performed to determine the precise channel sizes of biologically active substances formed in cellular membranes and to elucidate the mechanism of photo-inactivated action of porphyrins on bacterial membranes.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] A role for HSP70 in protecting against indomethacin-induced gastric lesions2009
Author(s)
Shintaro Suemasu, Ken-ichiro Tanaka, Takushi Namba, Tomoaki Ishihara, Takashi Katsu, Mitsuaki Fujimoto, Hiroaki Adachi, Gen Sobue, Koji Takeuchi, Akira Nakai, Tohru Mizushima
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Journal Title
The Journal of Biological Chemistry Vol.284,No.29
Pages: 19705-19715
Related Report
Peer Reviewed
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