Development of in silico prediction technique for pharmaceutical design and optimization

• Project/Area Number: 19590045
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Hoshi University
• Principal Investigator: TAKAYAMA Kozo Hoshi University, 薬学部, 教授 (00130758)
• Project Period (FY): 2007 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2007: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 製剤設計 / 最適化 / スプライン / ブートストラップ / インシリコ予測 / ベイジアンb\ネットワーク / 共分散構造分析 / ジルチアゼム塩酸塩 / 長期徐放システム / 潜在構造分析 / 自己組織化マップ / 薄板スプライン / 実験計画法 / ヒストグラム / 薄版スプライン / 信頼区間 / モンテカルロ探索 / デザインスペース / コントロールスペース / 感度分析

Research Abstract

A nonlinear response surface method incorporating thin-plate spline interpolation (RSM-S) was developed and applied to the designing a sustained release matrix tablet formulation. A bootstrap (BS) resampling method was employed to estimate confidence intervals of the optimal solution. As a result, the matrix tablet formulation with a constant release rate of the active ingredient for a long period was successfully optimized using RSM-S and the confidence interval of the optimal solution was adequately evaluated using BS.

Research Products

• [Journal Article] A statistical approach to the development of a transdermal delivery system for ondansetron (2010)
  • Author(s): Y.Obata, Y.Ashitaka, S.Kikuchi, K.Takayama
  • Journal Title: Int.J.Pharm. 399 Pages: 87-93
  • Peer Reviewed
• [Journal Article] Self-organizing map analysis using multivariate data from theophylline powders predicted by a thin-plate spline interpolation (2010)
  • Author(s): A.Yasuda, Y.Onuki, S.Kikuchi, K.Takayama
  • Journal Title: J.Pharm.Sci. 99 Pages: 4535-4542
  • Peer Reviewed
• [Journal Article] Creation of a tablet database containing several active ingredients and prediction of their pharmaceutical characteristics based on ensemble artificial neural networks (2010)
  • Author(s): K.Takagaki, H.Arai, K.Takayama
  • Journal Title: J.Pharm.Sci. 99 Pages: 4201-4214
  • Peer Reviewed
• [Journal Article] Role of individual test samples in optimal solutions in pharmaceuticals predicted using a nonlinear response surface method (2010)
  • Author(s): Y.Onuki, S.Kikuchi, A.Yasuda, K.Takayama
  • Journal Title: Int.J.Pharm. 396 Pages: 75-82
  • Peer Reviewed
• [Journal Article] Phase behavior in a ternary lipid membrane estimated using a nonlinear response surface method and Kohonen's self-organizing map (2010)
  • Author(s): Y.Onuki, K.Takayama
  • Journal Title: J.Col.Int.Sci. 343 Pages: 628-633
  • Peer Reviewed
• [Journal Article] Multivariate statistical approach to optimizing sustained-release tablet formulations containing diltiazem hydrochloride as a model highly water-soluble drug (2010)
  • Author(s): S.Kikuchi, K.Takayama
  • Journal Title: Int.J.Pharm. 386 Pages: 149-155
  • Peer Reviewed
• [Journal Article] Self-organizing map analysis using multivariate data from theophylline powders predicted by a thin-plate spline interpolation (2010)
  • Author(s): A.Yasuda
  • Journal Title: J.Pharm.Sci Volume: 99 Pages: 4535-4542
  • Peer Reviewed
• [Journal Article] Creation of a tablet database containing several active ingredients and prediction of their pharmaceutical characteristics based on ensemble artificial neural networks (2010)
  • Author(s): K.Takagaki
  • Journal Title: J.Pharm.Sci. Volume: 99 Pages: 4201-4214
  • Peer Reviewed
• [Journal Article] Role of individual test samples in optimal solutions in pharmaceuticals predicted using a nonlinear response surface method (2010)
  • Author(s): Y.Onuki
  • Journal Title: Int.J.Pharm. Volume: 396 Pages: 75-82
  • Peer Reviewed
• [Journal Article] Phase behavior in a ternary lipid membrane estimated using a nonlinear response surface method and Kohonen's self-organizing map (2010)
  • Author(s): Y.Onuki
  • Journal Title: J.Col.Int.Sci. Volume: 343 Pages: 628-633
  • Peer Reviewed
• [Journal Article] Multivariate statistical approach to optimizing sustained-release tablet formulations containing diltiazem hydrochloride as a model highly water soluble drug (2010)
  • Author(s): S.Kikuchi
  • Journal Title: Int.J.Pharm. Volume: 386 Pages: 149-155
  • Peer Reviewed
• [Journal Article] Effect of an experimental design for evaluating the nonlinear optimal formulation of theophylline tablets using a bootstrap resampling technique (2009)
  • Author(s): H.Arai, T.Suzuki, C.Kaseda, K.Takayama
  • Journal Title: Chem.Pharm.Bull. 57 Pages: 572-579
  • NAID: 130000124342
  • Peer Reviewed
• [Journal Article] Reliability assessment for the optimal formulations of pharmaceutical products predicted by a nonlinear response surface method (2009)
  • Author(s): S.Kikuchi, K.Takayama
  • Journal Title: Int.J.Pharm. 374 Pages: 5-11
  • Peer Reviewed
• [Journal Article] Effect of an experimental design for evaluating the nonlinear optimal formulation of theophylline tablets using a bootstrap resampling technique (2009)
  • Author(s): H. Arai, T. Suzuki, C. Kaseda, K. Takayama
  • Journal Title: Chem.Pharm.Bull. 57 Pages: 572-579
  • NAID: 130000124342
  • Peer Reviewed
• [Journal Article] Reliability assessment for the optimal formulations of pharmaceutical products predicted by a nonlinear response surface method (2009)
  • Author(s): S. Kikuchi, K. Takayama
  • Journal Title: Int.J.Pharm. 374 Pages: 5-11
  • Peer Reviewed
• [Journal Article] Complexation hydrogels for intestinal delivery of interon β and cacitonin (2009)
  • Author(s): N.Kamei
  • Journal Title: J.Controlled Rel. 134 Pages: 98-102
  • Peer Reviewed
• [Journal Article] Characterization of the inhibition of breast cancer resistance protein mediated efflux of mitoxantrone by pharmaceutical excipients (2009)
  • Author(s): T.Yamagata
  • Journal Title: Int.J.Pharm. 370 Pages: 216-219
  • Peer Reviewed
• [Journal Article] Effect of cell-penetrating peptides on the nasal absorption of insulin (2009)
  • Author(s): E.S.Khafagy
  • Journal Title: J.Controlled Rel. 133 Pages: 103-108
  • Peer Reviewed
• [Journal Article] Reliability assessment for the optimal formulations of pharmaceutical products predicted by a nonlinear response surface method (2009)
  • Author(s): S.Kikuchi
  • Journal Title: Int.J.Pharm. 374 Pages: 5-11
  • Peer Reviewed
• [Journal Article] Effect of an ecperimental design for evaluating the nonlinear optimal formulation of theophylline tablets using a bootstrap resampling technique (2009)
  • Author(s): H.Arai
  • Journal Title: Chem.Pharm.Bull. 57 Pages: 572-579
  • Peer Reviewed
• [Journal Article] Importance of intermolecular interaction on the improvement of intestinal therapeutic peptide/protain absorption using cell-penetraing peptides (2009)
  • Author(s): N.Kamei
  • Journal Title: J.Controlled Rel. 136 Pages: 179-186
  • Peer Reviewed
• [Journal Article] Pulmonary gene delivery of hybrid vector, lipopolyplex containing N-lauroylsarcosine, via the systemic route (2009)
  • Author(s): T.Kurosaki
  • Journal Title: J.Controlled Rel. 136 Pages: 213-219
  • Peer Reviewed
• [Journal Article] Effect of 1-menthol on the thermotropic behavior of ceramide 2/cholesterol mixtures as a model for the intercellular lipids in stratum corneum (2009)
  • Author(s): H.Watanabe
  • Journal Title: Colloid Sur.B : Biointerfaces 73 Pages: 116-121
  • Peer Reviewed
• [Journal Article] Efficiency of cell-penetraing peptides on the nasal and intestinal absorption of therapeutic peptides and protains (2009)
  • Author(s): E.S.Khafagy
  • Journal Title: Int.J.Pharm. 381 Pages: 49-55
  • Peer Reviewed
• [Journal Article] Evaluation of the structure and barrier function of a skin care formulation containing optically active ceramide 2 and cholesterol (2009)
  • Author(s): Y.Obata
  • Journal Title: Asian J.Pharm.Sci. 4 Pages: 292-299
  • Peer Reviewed
• [Journal Article] Prediction of survival and complications after percutaneous endoscopic gastrostomy in an individual by using clinical factors with an artificial neural network system (2009)
  • Author(s): T.Takayama
  • Journal Title: Eur.J.Gastroenterol.Hepatol. 21 Pages: 1279-1285
  • Peer Reviewed
• [Journal Article] Reliability assessment for the optimal formulations of pharmaceutical products predicted by a nonlinear response surface method (2009)
  • Author(s): S. Kikuchi
  • Journal Title: Int. J. Pharm. 374 Pages: 5-11
  • Peer Reviewed
• [Journal Article] Complexation hydrogels for intestinal delivery of interferon β and cacitonin (2009)
  • Author(s): N. Kamei
  • Journal Title: J. Controlled Rel. 134 Pages: 98-102
  • Peer Reviewed
• [Journal Article] Effect of cell-penetrating peptides on the nasal absorption of insulin (2009)
  • Author(s): E. S. Khafagy
  • Journal Title: J. Controlled Rel. 133 Pages: 103-108
  • Peer Reviewed
• [Journal Article] Displacement of tight junction proteins from detergent-resistant membrane domains by treatment with sodium caprate (2009)
  • Author(s): K. Sugibayashi
  • Journal Title: Eur. J. Pharm. Sci. 36 Pages: 246-253
  • Peer Reviewed
• [Journal Article] Development of photo-crosslinked polyacrylic acid hydrogel as an adhesive for dermatologocal patches : Involvement of formulation factors in physical properties and pharmacological effects (2008)
  • Author(s): Y.Onuki, M.Nishikawa, M.Morishita, K.Takayama
  • Journal Title: Int.J.Pharm. 349 Pages: 47-52
  • Peer Reviewed
• [Journal Article] Evaluation of the reliability of nonlinear optimal solutions in pharmaceuticals using a bootstrap resampling technique in combination with Kohonen's selforganizing maps (2008)
  • Author(s): Y.Onuki, K.Ohyama, C.Kaseda, H.Arai, T.Suzuki, K.Takayama
  • Journal Title: J.Pharm.Sci. 97 Pages: 331-339
  • Peer Reviewed
• [Journal Article] Development of photo- cross-linked polyacrylic acid hydrogel as an adhesive for dermatologocal patches : Involvement of formulation factors in physical properties and pharmacological effects (2008)
  • Author(s): Y. Onuki, M. Nishikawa, M. Morishita, K. Takayama
  • Journal Title: Int.J.Pharm. 349 Pages: 47-52
  • Peer Reviewed
• [Journal Article] Evaluation of the reliability of nonlinear optimal solutions in pharmaceuticals using a boot- strap resampling technique in combination with Kohonen's self-organizing maps (2008)
  • Author(s): Y. Onuki, K. Ohyama, C. Kaseda, H. Arai, T. Suzuki, K. Takayama
  • Journal Title: J.Pharm.Sci. 97 Pages: 331-339
  • Peer Reviewed
• [Journal Article] Time serious analysis of the clinical laboratory test result on chemotherapy for gastric cancer (2008)
  • Author(s): N. Sotoishi
  • Journal Title: J. Pharm. Pharmaceut. Sci. 11 Pages: 83-89
  • Peer Reviewed
• [Journal Article] Key functions in polymer carriers for intestinal absorption of insuhn (2008)
  • Author(s): K.Nakamura
  • Journal Title: Int.J.Pharm 354 Pages: 135-142
  • Peer Reviewed
• [Journal Article] Evaluation of the reliability of nonlinear optimal solutions inpharmaceuticals using a bootstrap resamphng technique in combination with Kohonen's self-organizing maps (2008)
  • Author(s): Y.Onuki
  • Journal Title: J.Pharm.Sci 97 Pages: 331-339
  • Peer Reviewed
• [Journal Article] Bootstrap re-sampling technique to evaluate the optimal formulation of theophylline tablets predicted by nonlinear response surface method incorporating multivariate spline interpolation (2007)
  • Author(s): H.Arai, T.Suzuki, C.Kaseda, K.Takayama
  • Journal Title: Chem.Pharm.Bull. 55 Pages: 586-593
  • NAID: 110006241822
  • Peer Reviewed
• [Journal Article] Bootstrap re-sampling technique to evaluate the optimal formulation of theophylline tablets predicted by nonlinear response surface method incorporating multivariate spline interpolation (2007)
  • Author(s): H. Arai, T. Suzuki, C. Kaseda, K. Takayama
  • Journal Title: Chem.Pharm.Bull. 55 Pages: 586-593
  • NAID: 110006241822
  • Peer Reviewed
• [Journal Article] Bootstrap re-sampling technique to evaluate the opthnal formulation of theophylline tablets predicted by no-linear response surface method incorporating multivariate spline interpolation (2007)
  • Author(s): H.Arai
  • Journal Title: Chem.Pharm.Bull 55 Pages: 586-593
  • Peer Reviewed
• [Presentation] A novel statistical approach in pharmaceutical formulation development (2010)
  • Author(s): K.Takayama
  • Organizer: Pharmaceutical Sciences World Congress(PSWC2010)
  • Place of Presentation: New Orleans, USA
  • Year and Date: 2010-11-16
• [Presentation] Novel statistical approach in pharmaceutical formulation development (2010)
  • Author(s): 高山幸三
  • Organizer: 2010 FIP Pharmaceutical Sciences World Congress (PSWC)
  • Place of Presentation: New Orleans, U.S.A.
  • Year and Date: 2010-11-14
• [Presentation] 錠剤処方データベースの構築と一般回帰ニューラルネットワークによる特性予測 (2010)
  • Author(s): 川合翔太、菊地伸吾、高山幸三
  • Organizer: 日本薬剤学会第25年会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-12
• [Presentation] ジルチアゼム塩酸塩放出制御型製剤における設計変数-内在因子-製剤特性の構造分析 (2010)
  • Author(s): 菊地伸吾、大貫義則、高山幸三
  • Organizer: 日本薬剤学会第25年会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-12
• [Presentation] ベイジアンネットワークを用いた固体分散体の設計変数と製剤特性間のモデル化 (2010)
  • Author(s): 林祥弘、菊地伸吾、高山幸三
  • Organizer: 日本薬剤学会第25年会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-12
• [Presentation] ブートストラップ法とKohonenの自己組織化マップを併用した非線形同時最適解の信頼性評価方法:同時最適解における個々の実験点の寄与 (2010)
  • Author(s): 大貫義則、菊地伸吾、安田昭仁、高山幸三
  • Organizer: 日本薬剤学会第25年会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-12
• [Presentation] ジルチアゼム塩酸塩放出制御型経口製剤における設計変数-内在因子-製剤特性の構造分析 (2010)
  • Author(s): 菊地伸吾
  • Organizer: 日本薬剤学会第25年会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-12
• [Presentation] ベイジアンネットワークを用いた固体分散体製剤の設計変数と製剤特性間のモデル化 (2010)
  • Author(s): 林祥弘
  • Organizer: 日本薬剤学会第25年会
  • Place of Presentation: 徳島
  • Year and Date: 2010-05-12
• [Presentation] 自己組織化マップとベイジアンネットワークを利用したテオフィリン錠処方の潜在構造モデリング (2010)
  • Author(s): 安田昭仁
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-29
• [Presentation] In silico解析による新規cell penetrating peptidesの開発 (2010)
  • Author(s): 寺澤義明
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-29
• [Presentation] 計量薬学的手法による製剤処方の最適化 (2010)
  • Author(s): 高山幸三
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] 自己組織化マップとベイジアンネットワークを利用したテオフィリン錠剤処方の潜在構造モデリング (2010)
  • Author(s): 安田昭仁、大貫義則、高山幸三
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] アンサンブルニューラルネットワークによる錠剤処方の特性予測:データベースの拡充と新規アルゴリズムの導入 (2010)
  • Author(s): 高垣恵介、荒井宏明、高山幸三
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-28
• [Presentation] Effect of an experimental design for evaluating the nonlinear optimal formulation of theophylline tablets using a bootstrap resampling technique (2009)
  • Author(s): H.Arai, T.Suzuki, H.Nakagami, C.Kaseda, K.Takayama
  • Organizer: 2009 AAPS Annual Meeting and Exposition
  • Place of Presentation: Los Angels, U.S.A.
  • Year and Date: 2009-11-08
• [Presentation] Effect of an experimental design for evaluating the nonlinear optimal formulation of theophylline tablets using a bootstrap resampling technique (2009)
  • Author(s): H.Arai
  • Organizer: 2009AAPS Annual Meeting and Exposition
  • Place of Presentation: Los Angeles, USA
  • Year and Date: 2009-11-08
• [Presentation] 実験計画法による実験点の抽出と解析 (2009)
  • Author(s): 高山幸三
  • Organizer: 第2回標準処方研究フォーラム
  • Place of Presentation: 名古屋
  • Year and Date: 2009-10-30
• [Presentation] A novel statistical method to setup the design space for the optimal formulations of pharmaceutical products (2009)
  • Author(s): 菊地伸吾, 高山幸三
  • Organizer: The 2nd Joint Symposium on Future Prospect of Pharmaceutical Sciences 2009
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2009-10-29
• [Presentation] セラミド含有脂質膜の角層細胞間脂質モデル膜としての有用性 (2009)
  • Author(s): 渡邉大至
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-22
• [Presentation] ジルチアゼム塩酸塩長期徐放システムの最適設計 (2009)
  • Author(s): 菊地伸吾、高山幸三
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-21
• [Presentation] 湿式微粒化装置によるO/W型エマルションの調製と評価 (2009)
  • Author(s): 西川昌人
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-21
• [Presentation] ジルチアゼム塩酸塩長期経口徐放システムの最適化 (2009)
  • Author(s): 菊地伸吾
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-21
• [Presentation] バイオ薬物の効率的消化管吸収を目指した新規細胞膜透過性ペプチドの開発 (2009)
  • Author(s): 寺澤義明
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-21
• [Presentation] 細胞膜透過性ペプチドによるインスリン吸収促進作用のCaco-2単層膜における評価 (2009)
  • Author(s): 山本修一
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-21
• [Presentation] Structural requirement of penetratin efficiency for insulin delivery (2009)
  • Author(s): E. S. Khafagy
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-21
• [Presentation] 湿式微粒化装置によるO/W型エマルジョンの調製と評価 (2009)
  • Author(s): 西川昌人
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-21
• [Presentation] ヒト角層細胞間脂質充填構造と製剤成分適用による影響 (2009)
  • Author(s): 小幡誉子
  • Organizer: 日本薬剤学会第24年会
  • Place of Presentation: 静岡
  • Year and Date: 2009-05-21
• [Presentation] PET技術を利用した消化管インスリン吸収の分子イメージング解析 (2009)
  • Author(s): 亀井敬泰
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-28
• [Presentation] 錠剤処方データベースの構築とアンサンブルニューラルネットワークによる特性予測 (2009)
  • Author(s): 高垣恵介、荒井宏明、高山幸三
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-26
• [Presentation] 薄板スプライン補間と自己組織化マップを利用した固形製剤処方の特性クラスタリング (2009)
  • Author(s): 安田昭仁、大貫義則、荒井宏明、高山幸三
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都
  • Year and Date: 2009-03-26
• [Presentation] モンテカルロシュミレーションによる製剤処方非線形最適解の信頼性評価 (2008)
  • Author(s): 菊地伸吾、高山幸三
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
• [Presentation] 脂質ラフトの形成機構解明を目的とした脂質二重膜モデルの膜物性評価 (2008)
  • Author(s): 大貫義則、高山幸三
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
• [Presentation] Anovel approach using functional peptides for efficient intestinal absorption of peptide and protein drugs (2007)
  • Author(s): M. Morishita, N. Kamei, K. Takayama
  • Organizer: The 6^<th> Retrometabolism Based Drug Design and Targeting Conference
  • Place of Presentation: Budapest, Hungary
  • Year and Date: 2007-06-04
• [Presentation] Computer-aided design and optimization for pharmaceutical formulations (2007)
  • Author(s): 高山幸三
  • Organizer: The 3rd Annual Pharmaceutical Sciences World Congress
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2007-04-22
• [Presentation] Computer-aided design and optimization for pharmaceutical formulations (2007)
  • Author(s): K. Takayama
  • Organizer: The 3^<rd> Annual Pharma- ceutical Sciences World Congress
  • Place of Presentation: Amsterdam, The Netherlands
  • Year and Date: 2007-04-22
• [Presentation] Formulation optimization of photocrosshnked polyacrylic acid hydrogel as an adhesive for dermatological patches:Evaluation of the reliability of nonlinear optimal formulation using a bootstrap resampling technique in combination with Kohonen's self-organizing map (2007)
  • Author(s): Y.Onuki
  • Organizer: The 34th Annual Meetting and Exposition of the Controned Release Society
  • Place of Presentation: Long Beach,CA,USA
• [Presentation] ブートストラップ法と自己組織化マップの併用による製剤処方最適解の信頼性評価 (2006)
  • Author(s): 大山康一, 紹田長生, 大貫義則, 森下真莉子, 高山幸三
  • Organizer: 日本薬剤学会第21年会
  • Place of Presentation: 金沢
  • Year and Date: 2006-03-16
• [Book] 造粒・打錠プロセスにおける適正操作とトラブル対策ノウハウ集 第7章 実験計画法による製剤の処方設計・最適化 (2010)
  • Author(s): 宮嶋勝春、高山幸三
  • Total Pages: 347
  • Publisher: 技術情報協会
• [Book] 最新・経皮吸収～開発の基礎から申請のポイントまで～第2章 経皮吸収型製剤の製剤設計 (2008)
  • Author(s): 小幡誉子、高山幸三
  • Total Pages: 296
  • Publisher: 情報機構
• [Book] 基礎から学ぶ製剤化のサイエンス 第1章 物質の溶解 (2008)
  • Author(s): 高山幸三
  • Total Pages: 335
  • Publisher: エルゼビア・ジャパン
• [Book] 最新・経皮吸収～開発の基礎から申請のポイントまで～(第2章 経皮吸収型製剤の製剤設計) (2008)
  • Author(s): 小幡誉子, 高山幸三
  • Publisher: 情報機構
• [Book] 基礎から学ぶ製剤化のサイエンス(第1章 物質の溶解) (2008)
  • Author(s): 高山幸三
  • Publisher: エルゼビア・ジャパン
• [Remarks]
  • URL: http://www.hoshi.ac.jp/home/kyoiku/koushitsuhgaid/10kyoushitsu.yakuzai.html