Involvement of RecQL4, a progeria syndrome responsible gene product, into the mechanism to maintain stability of genome structure.

• Project/Area Number: 19590053
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Tohoku University
• Principal Investigator: TADA Shusuke Tohoku University, 大学院・薬学研究科, 助教 (00216970)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 生化学 / ゲノム安定性維持 / Rothmund-Thomson症候群 / RecQL4 / 遺伝情報安定性維持機構 / DNA修復 / DNA複製 / DNA組え修復 / 非相同末端結合修復 / ポリADPリボシルポリメラーゼ / DNA組換え修復

Research Abstract

本研究では、Rothmund-Thomson症候群の原因遺伝子産物RecQL4の機能について検討した。まず、生化学と細胞生物学の手法により、RecQL4がポリADPリボシルポリメラーゼに依存する形でDNA損傷部位に集まり、損傷の修復に関わる可能性が示された。さらに、RecQL4と相互作用するタンパク質の同定を試みた結果、DNA損傷応答や転写に関連するタンパク質の他、様々なタンパク質修飾に関係したタンパク質と相互作用することが見出されたため、種々のタンパク質修飾がRecQL4の機能を調節していると考えられた。

Research Products

• [Journal Article] Accumulation of sumoylated Rad52 in checkpoint mutants perturbed in DNA replication (2009)
  • Author(s): Ohuchi, T., Seki, M., Kugou, K., Tada, S., Ohta, K., Enomoto, T.
  • Journal Title: DNA Repair (Amst) (in press)
  • Peer Reviewed
• [Journal Article] Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts (2009)
  • Author(s): Tsuyama, T., Watanabe, S., Aoki, A., Cho, Y., Seki, M., Enomoto, T., Tada, S.
  • Journal Title: Mol. Biol. Cell. 20 Pages: 937-947
  • Peer Reviewed
• [Journal Article] Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD2. Biochem. (2009)
  • Author(s): Takada, S., Inoue, E., Tano, K., Yoshii, H., Abe, T., Yoshimura, A., Akita, M., Tada, S., Watanabe, M., Seki, M., Enomoto, T.
  • Journal Title: Biophys. Res. Commun 379 Pages: 233-238
  • Peer Reviewed
• [Journal Article] Repression of nascent strand elongation by deregulated Cdt1 during DNA replication in Xenopus egg extracts (2009)
  • Author(s): Takashi Tsuyama, et.al.
  • Journal Title: Mol. Biol. Cell 20 Pages: 937-947
  • Peer Reviewed
• [Journal Article] Generation and characterization of cells that can be conditionally depleted of mitochondrial SOD2 (2009)
  • Author(s): Shunya Takada, et.al.
  • Journal Title: Biochem. Biophys. Res. Commun 379 Pages: 233-238
  • Peer Reviewed
• [Journal Article] A novel role for Rad17 in homologous recombination (2008)
  • Author(s): Nishino, K., Inoue, E., Takada, S., Abe, T., Akita, M., Yoshimura, A., Tada, S., Kobayashi, M., Yamamoto, K., Seki, M., Enomoto, T.
  • Journal Title: Genes. Genet. Syst 83 Pages: 427-431
  • Peer Reviewed
• [Journal Article] RecQ family helicases in genome stability : lessons from gene disruption studies in DT40 cells (2008)
  • Author(s): Seki, M., Otsuki, M., Ishii, Y., Tada, S., Enomoto, T.
  • Journal Title: Cell Cycle 7 Pages: 2472-2478
  • Peer Reviewed
• [Journal Article] KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation (2008)
  • Author(s): Abe, T., Ishiai, M., Hosono, Y., Yoshimura, A., Tada, S., Adachi, N., Koyama, H., Takata, M., Takeda, S., Enomoto, T., Seki, M.
  • Journal Title: Cell Signal 20 Pages: 1978-1985
  • Peer Reviewed
• [Journal Article] Rad52 sumoylation and its involvement in the efficient induction of homologous recombination (2008)
  • Author(s): Ohuchi, T., Seki, M., Branzei, D., Maeda, D., Ui, A., Ogiwara, H., Tada, S., Enomoto, T.
  • Journal Title: DNA Repair (Amst) 7 Pages: 879-889
  • Peer Reviewed
• [Journal Article] Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability. Genes (2008)
  • Author(s): Hayashi, T., Seki, M., Inoue, E., Yoshimura, A., Kusa, Y., Tada, S., Enomoto, T.
  • Journal Title: Genet. Syst 83 Pages: 95-100
  • Peer Reviewed
• [Journal Article] Insight into initiator-DNA interactions : a lesson from the archaeal ORC (2008)
  • Author(s): Tada, S., Kundu, L. R., Enomoto, T.
  • Journal Title: Bioessays 30 30 Pages: 208-211
  • Peer Reviewed
• [Journal Article] Analyses of functional interaction between RECQL1, RECQL5, and BLM which physically interact with DNA topoisomerase III (2008)
  • Author(s): Otsuki, M., Seki, M., Inoue, E., Abe, T., Narita, Y., Yoshimura, A., Tada, S., Ishii, Y., Enomoto, T.
  • Journal Title: Biochim. Biophys. Acta 1782 Pages: 75-81
  • Peer Reviewed
• [Journal Article] A novel role for Rad17 in homologous recombination (2008)
  • Author(s): Katsuaki Nishino, et.al.
  • Journal Title: Genes Genet. Syst 83 Pages: 427-431
  • Peer Reviewed
• [Journal Article] RecQ family helicases in genome stability : lessons from gene disruntion studies in DT40 cells (2008)
  • Author(s): Masayuki Seki, et.al.
  • Journal Title: Cell Cycle 7 Pages: 2472-2478
  • Peer Reviewed
• [Journal Article] KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation (2008)
  • Author(s): Takuya Abe, et.al.
  • Journal Title: Cell Signal 20 Pages: 1978-1985
  • Peer Reviewed
• [Journal Article] Rad52 sumoylation and its involvement in the efficient induction of homologous recombination (2008)
  • Author(s): Takashi Ohuchi, et.al.
  • Journal Title: DNA Repair 7 Pages: 879-889
  • Peer Reviewed
• [Journal Article] Vertebrate WRNIP1 and BLM are required for efficient maintenance of genome stability (2008)
  • Author(s): Tomoko Hayashi, et.al.
  • Journal Title: Genes Genet. Syst 83 Pages: 95-100
  • Peer Reviewed
• [Journal Article] Insight into initiator-DNA interactions : a lesson from the archaeal ORC (2008)
  • Author(s): Shusuke Tada, et.al.
  • Journal Title: Bioessays 30 Pages: 208-211
  • Peer Reviewed
• [Journal Article] Analyses of functional interaction between RECQL1, RECQL5, and BLM which physically interact with DNA topoisomerase IIIα (2008)
  • Author(s): Makoto Otsuki, et.al.
  • Journal Title: Biochim. Biophys. Acta 1782 Pages: 75-81
  • Peer Reviewed
• [Journal Article] Vertebrate WRNIP1 and BLM are required for efficient maintenance of genomestability (2008)
  • Author(s): Tomoko Hayashi, et. al.
  • Journal Title: Genes Genet Syst. 83 Pages: 95-100
  • Peer Reviewed
• [Journal Article] Insight into initiator-DNA interactions: a lesson from the archaeal ORC. (2008)
  • Author(s): Shusuke Tada, et. al.
  • Journal Title: Bioessays 30 Pages: 208-211
  • Peer Reviewed
• [Journal Article] Analyses of functional interaction between RECQL1, RECQL5, and BLM which physically interact with DNA topoisomerase IIIα. (2008)
  • Author(s): Makoto Otsuki, et. al.
  • Journal Title: Biochim Biophys Acta 1782 Pages: 75-81
  • Peer Reviewed
• [Journal Article] Functional interactions between BLM and XRCC3 in the cell (2007)
  • Author(s): Otsuki, M., Seki, M., Inoue, E., Yoshimura, A., Kato, G., Yamanouchi, S., Kawabe, Y., Tada, S., Shinohara, A. Komura, J., Ono, T., Takeda, S., Ishii, Y., Enomoto, T.
  • Journal Title: J. Cell Biol 179 Pages: 53-63
  • Peer Reviewed
• [Journal Article] Ctf18 is required for homologous recombination-mediated double-strand break repair (2007)
  • Author(s): Ogiwara, H., Ohuchi, T., Ui, A., Tada, S., Enomoto, T., Seki, M.
  • Journal Title: Nucleic Acids Res 35 Pages: 4989-5000
  • Peer Reviewed
• [Journal Article] WRN functions in a RAD18-dependent damage avoidance pathway (2007)
  • Author(s): Dong, Y. P., Seki, M., Yoshimura, A., Inoue, E., Furukawa, S., Tada, S., Enomoto, T.
  • Journal Title: Biol. Pharm. Bull. 30 Pages: 1080-1108
  • Peer Reviewed
• [Journal Article] Rad50 is involved in MMS-induced recombination between homologous chromosomes in mitotic cells (2007)
  • Author(s): Tomizawa, Y., Ui, A., Onoda, F., Ogiwara, H., Tada, S., Enomoto, T., Seki, M.
  • Journal Title: Genes. Genet. Syst 82 Pages: 157-160
  • Peer Reviewed
• [Journal Article] Activation of a novel pathway involving Mms1 and Rad59 in sgs1 cells (2007)
  • Author(s): Ui, A., Seki, M., Ogiwara, H., Lai, M. S., Yamamoto, K., Tada, S., Enomoto, T.
  • Journal Title: Biochem. Biophys. Res. Commun 356 Pages: 1031-1037
  • Peer Reviewed
• [Journal Article] The INO80 complex is required for damage-induced recombination (2007)
  • Author(s): Kawashima, S., Ogiwara, H., Tada, S., Harata, M., Wintersberger, U., Enomoto, T., Seki, M.
  • Journal Title: Biochem. Biophys. Res. Commun 355 Pages: 835-841
  • Peer Reviewed
• [Journal Article] Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopus egg extracts (2007)
  • Author(s): Kumata, Y., Tada, S., Yamanada, Y., Tsuyama, T., Kobayashi, T., Dong, Y. P., Ikegami, K., Murofushi, H., Seki, M., Enomoto, T.
  • Journal Title: Biochim. Biophys. Acta 1773 Pages: 556-564
  • Peer Reviewed
• [Journal Article] WRN counteracts the NHEJ pathway upon camptothecin exposure (2007)
  • Author(s): Otsuki, M., Seki, M., Kawabe, Y., Inoue, E., Dong, Y. P., Abe, T., Kato, G., Yoshimura, A., Tada, S., Enomoto, T.
  • Journal Title: Biochem. Biophys. Res. 355 Pages: 477-482
  • Peer Reviewed
• [Journal Article] Cdt1 and geminin : role during cell cycle progression and DNA damage in higher eukaryotes (2007)
  • Author(s): Tada, S.
  • Journal Title: Front. Biosci 12 Pages: 1629-1641
  • Peer Reviewed
• [Journal Article] Functional interactions between BLM and XRCC3 in the cell. (2007)
  • Author(s): Makoto Otsuki, et. al.
  • Journal Title: J Cell Biol 179 Pages: 53-63
  • Peer Reviewed
• [Journal Article] Ctfl8 is required for homologous recombination-mediated double-strand break repair. (2007)
  • Author(s): Hideaki Ogiwara, et. al.
  • Journal Title: Biochim Biophys Acta 1782 Pages: 75-81
  • Peer Reviewed
• [Journal Article] WRN functions in a RAD18-dependent damage avoidance pathway. (2007)
  • Author(s): Yu Peng Dong, et. al.
  • Journal Title: Biol Pharm Bull 30 Pages: 1080-1083
  • Peer Reviewed
• [Journal Article] Rad50 is involved in MMS-induced recombination between homologous chromosomes in mitotic cells. (2007)
  • Author(s): Yuji Tomizawa, et. al.
  • Journal Title: Genes Genet Syst 82 Pages: 157-160
  • Peer Reviewed
• [Journal Article] Activation of a novel pathway involving Mmsl and Rad59 in sgsl cells. (2007)
  • Author(s): Ayako Ui, et. al.
  • Journal Title: Biochem Biophys Res Commun 356 Pages: 1031-1037
  • Peer Reviewed
• [Journal Article] The INO80 complex is required for damage-induced recombination. (2007)
  • Author(s): Satoshi Kawashima, et. al.
  • Journal Title: Biochem Biophys Res Commun 355 Pages: 835-841
  • Peer Reviewed
• [Journal Article] Possible involvement of RecQL4 in the repair of double-strand DNA breaks in Xenopusegg extracts. (2007)
  • Author(s): Yuji Kumata, et. al.
  • Journal Title: Biochim Biophys Acta 1773 Pages: 556-564
  • Peer Reviewed
• [Journal Article] WRN counteracts the NHEJ pathway upon camptothecin exposure. (2007)
  • Author(s): Makoto Otsuki, et. al.
  • Journal Title: Biochem Biophys Res Commun 355 Pages: 477-482
  • Peer Reviewed
• [Presentation] SOD1枯渇によるゲノムの不安定化と細胞死はアスコルビン酸で抑制される (2009)
  • Author(s): 井上絵里, ほか
  • Organizer: 日本薬学会第129年会
  • Place of Presentation: 京都(京都府)
  • Year and Date: 2009-03-26
• [Presentation] SOD1枯渇によるゲノムの不安定化と細胞死はアスコルビン酸で抑制される (2008)
  • Author(s): 井上絵里、田野恵三、吉居華子、多田周右、渡邉正巳、関政幸、榎本武美
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-12
• [Presentation] 高等動物細胞におけるチェックポイント因子Claspinの機能の解析 (2008)
  • Author(s): 秋田玄武、関政幸、吉村明、阿部拓也、多田周右、榎本武美
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-11
• [Presentation] WRNIP1はRAD18-RAD6に結合し、RAD18-RAD6のもつ複製フォーク様構造への結合を阻害する (2008)
  • Author(s): 吉村明、金森允、多田周右、立石智、関政幸、榎本武美
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-11
• [Presentation] DNA傷害に応じたRecQL4の動態と相互作用タンパク質の機能解明 (2008)
  • Author(s): 池上京子、多田周右、Li Lan、菅野新一郎、安井明、関政幸、榎本武美
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-10
• [Presentation] Nascent DNA elongation is repressed by deregulated Cdt1 in Xenopus egg extracts (2008)
  • Author(s): 津山崇、渡辺沙里、青木彩子、関政幸、榎本武美、多田周右
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸市
  • Year and Date: 2008-12-09
• [Presentation] DNA複製開始調節におけるCdc6の機能の解析 (2008)
  • Author(s): Lena R. Kundu, ほか
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸(兵庫県)
  • Year and Date: 2008-12-09
• [Presentation] Nascent DNA elongation is repressed by deregulated Cdt1 in Xenopus egg extracts (2008)
  • Author(s): 津山崇, ほか
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸(兵庫県)
  • Year and Date: 2008-12-09
• [Presentation] WRNIP1はRAD18-RAD6に結合し、RAD18-RAD6のもつ複製フォーク様構造への結合を阻害する (2008)
  • Author(s): 吉村明, ほか
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸(兵庫県)
  • Year and Date: 2008-12-09
• [Presentation] DNA傷害に応じたRecQL4の動態と相互作用タンパク質の機能解明 (2008)
  • Author(s): 池上京子, ほか
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸(兵庫県)
  • Year and Date: 2008-12-09
• [Presentation] 高等動物細胞におけるチェックポイント因子Claspinの機能の解析 (2008)
  • Author(s): 秋田玄武, ほか
  • Organizer: 第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸(兵庫県)
  • Year and Date: 2008-12-09
• [Presentation] Functional analysis of RecQL4 using RecQL4 mutated cells (2008)
  • Author(s): Abe, T., Seki, M., Ikegami, K., Yoshimura, A., Tada, S., Enomoto, T.
  • Organizer: The 6th 3R Symposium
  • Place of Presentation: 嬬恋
  • Year and Date: 2008-10-29
• [Presentation] Effects of deregulating Cdc6 during the initiation of DNA replication (2008)
  • Author(s): Kundu, L. R., Kumata, Y., Tsuyama, T., Seki, M., Enomoto, T., Tada, S.
  • Organizer: The 6th 3R Symposium
  • Place of Presentation: The 6th 3R Symposium
  • Year and Date: 2008-10-28
• [Presentation] Repression of nascent strand elongation of DNA replication by deregulated Cdt1 in Xenopus egg extracts (2008)
  • Author(s): Tsuyama, T., Watanabe, S., Aoki, A., Cho, Y., Seki, M., Enomoto, T., Tada, S.
  • Organizer: The 6th 3R Symposium
  • Place of Presentation: 嬬恋
  • Year and Date: 2008-10-28
• [Presentation] Repression of nascent strand elongation of DNA replication by deregulated Cdtl in Xenopus egg extracts (2008)
  • Author(s): Takashi Tsuyama, et.al.
  • Organizer: The 6th 3R Symposium
  • Place of Presentation: 嬬恋(静岡県)
  • Year and Date: 2008-10-27
• [Presentation] Significance of regulating Cdc6 during the initiation of DNA replication (2008)
  • Author(s): Kundu, L. R., Kumata, Y., Tsuyama, T., Seki, M., Enomoto, T., Tada, S.
  • Organizer: NCRI Cancer Conference 2008
  • Place of Presentation: Birmingham, UK
  • Year and Date: 2008-10-05
• [Presentation] Significance of regulating Cdc6 during the initiation of DNA replication (2008)
  • Author(s): Lena R. Kundu, et.al.
  • Organizer: NCRI Cancer Conference
  • Place of Presentation: Birmingham, England
  • Year and Date: 2008-10-05
• [Presentation] Inhibition of DNA Replication by the Replication Licensing Factor Cdc6 (2008)
  • Author(s): Kundu, L. R., Tada, S., Kumata, Y., Tsuyama, T., Seki, M., Enomoto, T.
  • Organizer: Second JCA-AACR Special Joint Conference
  • Place of Presentation: 淡路市
  • Year and Date: 2008-07-15
• [Presentation] Inhibition of DNA Replication by the Replication Licensing Factor Cdc6 (2008)
  • Author(s): Lena R. Kundu, et.al.
  • Organizer: Second JCA-AACR Special Joint Conference
  • Place of Presentation: 淡路島(兵庫県)
  • Year and Date: 2008-07-14
• [Presentation] RecQL4のDNA二本鎖切断誘発時における挙動の解析 (2008)
  • Author(s): 池上京子、多田周右、Li Lan、安井明、関政幸、榎本武美
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜市
  • Year and Date: 2008-03-27
• [Presentation] RecQL4のDNA二本鎖切断誘発時における挙動の解析 (2008)
  • Author(s): 池上京子, ほか
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2008-03-26
• [Presentation] 異所的なCdt1活性に伴うDNA複製抑制機構の解析 (2008)
  • Author(s): 津山崇、渡辺沙里、青木彩子、関政幸、榎本武美、多田周右
  • Organizer: 第19回DNA複製・分配ワークショップ2007年度組換え・染色体再編ワークショップ合同ワークショップ
  • Place of Presentation: 伊豆市
  • Year and Date: 2008-03-06
• [Presentation] Cdc6によるDNA複製開始過程の抑制 (2008)
  • Author(s): Lena R. Kundu、熊田祐司、津山崇、関政幸、榎本武美、多田周右
  • Organizer: 第19回DNA複製・分配ワークショップ2007年度組換え・染色体再編ワークショップ合同ワークショップ
  • Place of Presentation: 伊豆市
  • Year and Date: 2008-03-06
• [Presentation] 異所的なCdt1活性に伴うDNA複製抑制機構の解析 (2008)
  • Author(s): 津山崇, ほか
  • Organizer: 第19回DNA複製・分配ワークショップ
  • Place of Presentation: ラフォーレ修善寺(伊豆市)
  • Year and Date: 2008-03-04
• [Presentation] Cdc6によるDNA複製開始過程の抑制 (2008)
  • Author(s): Lena R. Kundu, ほか
  • Organizer: 第19回DNA複製・分配ワークショップ
  • Place of Presentation: ラフォーレ修善寺(伊豆市)
  • Year and Date: 2008-03-04
• [Presentation] ニワトリDT40細胞を用いた抗酸化酵素遺伝子破壊株の解析 (2007)
  • Author(s): 井上絵里、関政幸、吉村明、櫻場秀一、多田周右、榎本武美
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-12-14
• [Presentation] WRNIP1とRAD18の機能的連携の解明 (2007)
  • Author(s): 吉村明、関政幸、多田周右、榎本武美
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-12-13
• [Presentation] DNA複製ライセンス化因子Cdt1の機能ドメインに関する生化学的解析 (2007)
  • Author(s): 川端亮介、津山崇、多田周右、関政幸、榎本武美
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-12-11
• [Presentation] 出芽酵母DNA polymerase δ Pol31サブユニットの機能ドメインの解析 (2007)
  • Author(s): 井坂弘道、前田大介、Davoodi Vijeh Motlagh Niloofar、多田周右、関政幸、榎本武美
  • Organizer: 第30回日本分子生物学会年会・第80回日本生化学会大会合同大会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-12-11
• [Presentation] DNA複型ラノセンス化因子Cdt1の機能ドメインに関する生化学的解析 (2007)
  • Author(s): 川端亮介, ほか
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2007-12-11
• [Presentation] WRNIP1とRAD18の機能的連携の解明 (2007)
  • Author(s): 吉村明, ほか
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2007-12-11
• [Presentation] ニワトリDT40細胞を用いた抗酸化酵素遺伝子破壊株の解析 (2007)
  • Author(s): 井上絵里, ほか
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2007-12-11
• [Presentation] 出芽酵母DNA polymeraseδPol31サブユニットの機能ドメインの解析 (2007)
  • Author(s): 井坂弘道, ほか
  • Organizer: 第30回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2007-12-11
• [Presentation] Illegitimate activation of Cdt1 at S-phase possibly leads to a halt of nascent strand elongation in DNA re-replication (2007)
  • Author(s): 多田周右、関政幸、榎本武美
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2007-10-05
• [Presentation] Illegitimate activation of Cdt1 at S-phase possibly leads to a halt of nascent strand elongation in DNA re-replication. (2007)
  • Author(s): Shusuke Tada, ほか
  • Organizer: 第66回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2007-10-03
• [Presentation] Cdc6 inhibits the initiation of DNA replication by modulating Cdc7-dependent hyperphosphorylation of Mcm4 (2007)
  • Author(s): Kundu, L. R., Kumata, Y., Tsuyama, T., Seki, M., Enomoto, T., Tada, S.
  • Organizer: Cold Spring Harbor Laboratory Meeting on Eukaryotic DNA Replication and Genome Maintenance
  • Place of Presentation: New York, USA
  • Year and Date: 2007-09-06
• [Presentation] Cdc6 inhibits the initiation of DNA replication by modulating Cdc7-dependent hyperphosphorylation of Mcm4. (2007)
  • Author(s): Lena R. Kundu, ほか
  • Organizer: Cold Spring Harbor Laboratory Meeting on Eukaryotic DNA Replication and Genome Maintenance
  • Place of Presentation: Cold Spring Harbor Laboratory, New York, USA
  • Year and Date: 2007-09-05
• [Presentation] Gemininは再複製時における複製フォークの停止を抑制する (2007)
  • Author(s): 津山崇、渡辺沙里、青木彩子、関政幸、榎本武美、多田周右
  • Organizer: 第40回日本発生生物学会・第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡市
  • Year and Date: 2007-05-29
• [Presentation] Gemininは再複製時における複製フォークの停止を抑制する (2007)
  • Author(s): 津山崇, ほか
  • Organizer: 第59回日本細胞生物学会
  • Place of Presentation: 福岡国際会議場(福岡市)
  • Year and Date: 2007-05-28
• [Book] 分子生物学イラストレイテッド改訂第3版(DNAの複製) (2009)
  • Author(s): 多田周右、榎本武美
  • Publisher: 羊土社