Primary approach for therapy of fibrosis by manipulating angiogenesis induced by biologically active autocoids

• Project/Area Number: 19590072
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Nihon Pharmaceutical University
• Principal Investigator: HAYASHI Izumi Nihon Pharmaceutical University, 医療薬学科, 教授 (90172999)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2007: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: オータコイド / 線維化 / 血管新生 / 生理活性 / カルシトニン遺伝子関連ペプチド / 創傷治癒 / 細胞・組織 / 薬理学 / プロスタグランジン / 神経ペプチド / リポキシン

Research Abstract

Fibrosis is an essential event for repair of damaged tissue in wound healing. However, delay of wound healing or dysfunction of organ by excessive fibrosis resulting deterioration of prognosis in the disease. In the present study, calcitonin gene-related peptide (CGRP) neurogenically released from primary afferent sensory neurons, could repair the impaired tissue via angiogenesis, suggesting a significant involvement of the autocoid in formation of granuloma and fibrogenesis.

Research Products

• [Journal Article] Recruited bone marrow cells expressing the EP3 prostaglandin E receptor subtype enhance angiogenesis during chronic inflammation. (2010)
  • Author(s): Ueno T, Suzuki T, Oikawa A, Hosono K, Kosaka Y, Amano H, Kitasato H, Toda M, Hayashi I, Kato T, Ito Y, Sugimoto Y, Narumiya S, Okamoto H, Majima M
  • Journal Title: Biomed Pharmacother. 64 Pages: 93-100
  • Peer Reviewed
• [Journal Article] Host prostaglandin EP3 receptor signaling relevant to tumor-associated lymphangiogenesis. (2010)
  • Author(s): Kubo H, Hosono K, Suzuki T, Ogawa Y, Kato H, Kamata H, Ito Y, Amano H, Kato T, Sakagami H, Hayashi I, Sugimoto Y, Narumiya S, Watanabe M, Majima M
  • Journal Title: Biomed Pharmacother. 64 Pages: 101-106
  • Peer Reviewed
• [Journal Article] Effects of inhaled monoethanolamine on bronchoconstristion. (2009)
  • Author(s): Kamijo Y, Hayashi I, Ide A, Yoshimura K, Soma K, Majima M
  • Journal Title: J Appl Toxicol. 29 Pages: 15-19
  • Peer Reviewed
• [Journal Article] An ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein. (2009)
  • Author(s): Kamata Y, Fujita T, Kato T, Hayashi I, Kurosaka M, Katori M, Fujita Y, Majima M
  • Journal Title: Hypertens Res. 32 Pages: 220-226
  • NAID: 10024830128
  • Peer Reviewed
• [Journal Article] Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth. (2009)
  • Author(s): Ogawa Y, Suzuki T, Oikawa A, Hosono K, Kubo H, Amano H, Ito Y, Kitasato H, Hayashi I, Kato T, Sugimoto Y, Narumiya S, Watanabe M, Majima M
  • Journal Title: Biochem Biophys Res Commun. 15
  • Peer Reviewed
• [Journal Article] Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis. (2009)
  • Author(s): Amano H, Ito Y, Suzuki T, Kato S, Matsui Y, Ogawa F, Murata T. Sugimoto Y, Senior R, Kitasato H, Hayashi I, Satoh Y, Narumiya S, Majima M
  • Journal Title: Cancer Sci. 100 Pages: 2318-2324
  • NAID: 10027198074
  • Peer Reviewed
• [Journal Article] Role of prostagladin (PG) and peroxisome proliferator-activated gamma (PPAR・) in pulmonary fibrosis. (2009)
  • Author(s): Hayashi I, Endo H, Katagiri M, Kitasato H
  • Journal Title: Current Respiratory Med Rev 5 Pages: 3-5
  • Peer Reviewed
• [Journal Article] An ATP-sensitive potassium channel blocker suppresses sodium-induced hypertension through increased secretion of urinary kallikrein (2009)
  • Author(s): Kamata Y, et al.
  • Journal Title: Hypertens Res 32 Pages: 220-226
  • Peer Reviewed
• [Journal Article] Bone marrow-derived EP3-expressing stromal cells enhance tumor-associated angiogenesis and tumor growth (2009)
  • Author(s): Ogawa Y, et al.
  • Journal Title: Biochem Biophys Res Commun 382 Pages: 720-725
  • Peer Reviewed
• [Journal Article] Roles of a prostaglandin E-type receptor, EP3, in upregulation of matrix metalloproteinase-9 and vascular endothelial growth factor during enhancement of tumor metastasis (2009)
  • Author(s): Amano H, et al.
  • Journal Title: Cancer Sci 100 Pages: 2318-2324
  • Peer Reviewed
• [Journal Article] Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ucer healing and angiogenesis. (2008)
  • Author(s): Ohno T, Hattori Y, Komine R, Ae T, Mizuguchi S, Arai K, Saeki T, Suzuki T, Hosono K, Hayashi I, Oh-Hashi Y, Kurihara Y, Kurihara H, Amagase K, Okabe S, Saigenji K, Majima M
  • Journal Title: Gastroenterology 134 Pages: 215-225
  • Peer Reviewed
• [Journal Article] Roles of calcitonin gene-related peptide in facilitation of wound healing and angiogenesis. (2008)
  • Author(s): Toda M, Suzuki T, Hosono K, Kurihara Y, Kurihara H, Hayashi I, Kitasato H, Hoka S, Majima M
  • Journal Title: Biomed Pharmacother. 62(6) Pages: 352-359
  • Peer Reviewed
• [Journal Article] Neuronal system-dependent facilitation of tumor angiogenesis and tumor groeth by calctionin gene-related peptide. (2008)
  • Author(s): Toda M, Suzuki T, Hosono K, Hayashi I, Hashida S, Onuma Y, Amano H, Kurihara Y, Kurihara H, Okamoto H, Hoka S, Majima M
  • Journal Title: Proc.Natl Acad Sci USA. 105 Pages: 13550-13555
  • Peer Reviewed
• [Journal Article] Roles of calcitonin gene-related peptide in maintenance of gastric mucosal integrity and in enhancement of ulcer healing and angiogenesis. (2008)
  • Author(s): Ohno T, et al.
  • Journal Title: Gastroenterology 134 Pages: 215-225
  • Peer Reviewed
• [Journal Article] Roles of calcitonin gene-related peptide in facilitation of wound healing and angiogenesis (2008)
  • Author(s): Toda M, et al.
  • Journal Title: Biomedicine & Pharmacotherapy 62 Pages: 352-359
  • Peer Reviewed
• [Journal Article] Glucocorticoids co-interact with lipoxin A4 via lipoxin A4 receptor(ALX) up-regulation. (2007)
  • Author(s): Hashimoto A, Murakami Y, Kitasato H, Hayashi I, Endo H
  • Journal Title: Biomed Pharmacother. 61 Pages: 81-85
  • Peer Reviewed
• [Journal Article] Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of patients with rheumatoid arthritis. (2007)
  • Author(s): Hashimoto A, Hayashi I, Murakami Y, Sato Y, Kitasato H, Matsushita R, Iizuka N, Urabe K, Itoman M, Hirohata S, Endo H
  • Journal Title: J Rheumatol. 34 Pages: 2144-2153
  • Peer Reviewed
• [Journal Article] Antiinflammatory mediator lipoxin A4 and its receptor in synovitis of patients with Rhematoid arthritis (2007)
  • Author(s): Hashimoto A, et. al.
  • Journal Title: Journal of Rheumatology 34 Pages: 2144-2153
  • Peer Reviewed
• [Journal Article] Glucocorticoids co-interact with lipoxin A4 via lipoxin A4 receptor(ALX)up-regulation (2007)
  • Author(s): Hashimoto A, et. al.
  • Journal Title: Biomedicine & Pharmacotherapy 61 Pages: 81-85
  • Peer Reviewed