The role of extracellular adenosine deaminase (ADGF/CECR1) in the vertebrate development
| Project/Area Number |
19590078
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Biological pharmacy
|
|---|
| Research Institution | Teikyo University |
|---|
Principal Investigator |
HONMA Koichi Teikyo University, 薬学部, 教授 (90251438)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
山口 真二 帝京大学, 薬学部, 助教 (60398740)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
YAMAGUCHI Shiji 帝京大学, 薬学部, 薬学部 (60398740)
|
|---|
| Project Period (FY) |
2007 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
|
|---|
| Keywords | アデノシンデアミナーゼ / ADGF / CECR1 / IDGF / ニワトリ / アフリカツメガエル / 細胞増殖 / 酵素 |
|---|
| Research Abstract |
細胞外に分泌されるアデノシンデアミナーゼ(ADA)を、昆虫細胞由来の増殖因子として発見し、昆虫の胚発生での重要性を示しました。現在では、この酵素がヒトを含む多くの動物種で保存されていることがわかり、新しい遺伝子(ADGF/CECR1)ファミリーとして認知されています。さらに、脊椎動物における機能を解析し、ADGF/CECR1が体節形成に関わる重要な遺伝子であることを示しました。この遺伝子のユニークな特徴は、細胞外アデノシン量を低下させることにより、アデノシン受容体を経由した細胞内シグナル伝達を変化させることです。一連の解析を通じて、アデノシンの細胞外代謝の生理的意義を示しました。
|
Report
(3 results)
Research Products
(27 results)
-
[Journal Article] The extracellular adenosine deaminase growth factor, ADGF/CECRI, plays a role in Xenopus embryogenesis via the adenosine/P1 receptor2008
Author(s)
Iijima, R., Kunieda, T., Yamaguchi, S., Kamigaki, H., Fujii-Taira, I., Selcimizu, K., Kubo, T., Natori, S. and Homma, K. J.
-
Journal Title
J.Biol.Chem. 283
Pages: 2255-2264
Related Report
Peer Reviewed
-
[Journal Article] Gene expression profile in cerebrum in the filial imprinting of domestic chick(Gallus gallus domesticlis)2008
Author(s)
Yamaguchi, S., Fujii-Taira, I., Katagiri, S., Izawa, E., Fujimoto, Y., Takeuchi, H., Takano, T., Matsushima, T. and Homma, K. J.
-
Journal Title
Brain Res. Bull. 76
Pages: 275-281
Related Report
Peer Reviewed
-
[Journal Article] Up-regulation of microtubule-associated protein 2 accompanying the filial imprinting of domestic chick(Gallus gallus domesticus)2008
Author(s)
Yamaguchi, S., Fujii-Taira, I., Murakarni, A., Hirose, N., Aoki, N., Izawa, E., Fujimoto, Y., Takano, T., Matsushima, T., and Homma, K. J.
-
Journal Title
Brain Res. Bull. 76
Pages: 282-288
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] In vivo gene transfer into newly-hatched chick brain by electroporation2007
Author(s)
Yamaguchi, S., Katagiri, S., Hirose, N., Fujimoto, Y., Mori, M., Fujii-Taira, I., Takano, T., Matsushima, T. and Homma, K. J.
-
Journal Title
Neuroreport 18
Pages: 735-739
Related Report
Peer Reviewed
-
[Journal Article] Truncated TrIcB-T1 regulates the morphology of neocortical layer I astrocytes in adult rat brain slices2007
Author(s)
Ohira, K., Funatsu, N., Homma, K. J., Sahara, Y., Hayashi, M., Kaneko, T. and Nakamura, S.
-
Journal Title
Eur. J. Neurosci 25
Pages: 406-416
Related Report
Peer Reviewed
-
[Journal Article] Involvement of long chain acyl-CoA synthetase in local synthesis of neutral lipids in cytoplasmic lipid droplets in human hepatocyte HuH72007
Author(s)
Fujimoto, Y., Itabe, H., Kinoshita, T., Homma, K. J., Onoduka, J., Mori, M., Yamaguchi, S., Makita, M., Higashi, Y., Yamashita, A. and Takano, T.
-
Journal Title
J Lipid Res 48
Pages: 1280-1292
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
