Memory-enhancing effects of flavonoids
Project/Area Number |
19590086
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biological pharmacy
|
Research Institution | Musashino University |
Principal Investigator |
ABE Kazuho Musashino University, 薬学研究所, 教授 (60202660)
|
Project Period (FY) |
2007 – 2009
|
Project Status |
Completed (Fiscal Year 2009)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | フラボノイド / フィセチン / 海馬 / 長期増強 / MAPキナーゼ / ERK / 記憶 / 認知症 / 構造活性相関 |
Research Abstract |
To find a new therapy for treatment of memory impairment in patients with senile dementia, this study investigated mechanisms underlying the memory-enhancing effect of fisetin, a flavonoid, and found that fisetin promoted hippocampal synaptic plasticity by activating ERK signal in a cAMP-independent manner. In addition, a structure-activity study provided a new compound that promotes hippocampal synaptic plasticity with higher potency than fisetin.
|
Report
(4 results)
Research Products
(8 results)