Memory-enhancing effects of flavonoids

• Project/Area Number: 19590086
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Musashino University
• Principal Investigator: ABE Kazuho Musashino University, 薬学研究所, 教授 (60202660)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2007: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: フラボノイド / フィセチン / 海馬 / 長期増強 / MAPキナーゼ / ERK / 記憶 / 認知症 / 構造活性相関

Research Abstract

To find a new therapy for treatment of memory impairment in patients with senile dementia, this study investigated mechanisms underlying the memory-enhancing effect of fisetin, a flavonoid, and found that fisetin promoted hippocampal synaptic plasticity by activating ERK signal in a cAMP-independent manner. In addition, a structure-activity study provided a new compound that promotes hippocampal synaptic plasticity with higher potency than fisetin.

Research Products

• [Journal Article] Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid beta protein. (2008)
  • Author(s): Akaishi T, Morimoto T, Shibao M, Watanabe S, Sakai-Kato K, Utsunomiya-Tate N, Abe K
  • Journal Title: Neuroscience Letters 444 Pages: 1419-1424
  • Peer Reviewed
• [Journal Article] Structural requirements for the flavonoid fisetin in inhibiting fibril formation of amyloid beta protein. (2008)
  • Author(s): Tatsuhiro Akaishi
  • Journal Title: Neuroscience Letters 444 Pages: 1419-1424
  • Peer Reviewed
• [Presentation] フィセチンの経口投与は麻酔ラットの海馬CA1領域における長期増強を特異的に促進する (2010)
  • Author(s): 阿部和穂
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜(横浜)
  • Year and Date: 2010-03-17
• [Presentation] フィセチンの経口投与は麻酔ラットの海馬CA1領域における長期増強を特異的に促進する (2009)
  • Author(s): 阿部 和穂
  • Organizer: 第82回日本薬理学会年会
  • Place of Presentation: パシフィコ横浜 (横浜)
  • Year and Date: 2009-03-17
• [Presentation] フィセチンはアミロイドβ蛋白凝集阻害作用と海馬長期増強をあわせもつ (2008)
  • Author(s): 赤石樹泰
  • Organizer: 第116回日本薬理学会関東部会
  • Place of Presentation: 日本大学カザルスホール(東京都千代田区)
  • Year and Date: 2008-06-02
• [Presentation] フィセチンはアミロイドβ蛋白凝集阻害作用と海馬長期増強促進作用をあわせもつ (2007)
  • Author(s): 赤石 樹泰
  • Organizer: 第116回日本薬理学会関東部会
  • Place of Presentation: 日本大学カザルスホール(東京都千代田区)
  • Year and Date: 2007-06-02
• [Remarks]
  • URL: http://www.musashino-u.ac.jp/yakugaku/yakuri/m-yakuri-home.html
• [Remarks]
  • URL: http://www.musashino-u.ac.jp/yakugaku/yakuri/m-yakuri-home.html