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Investigation of fibrinolytic system on differentiation of adipocytes and establishment of therapeutic strategy

Research Project

Project/Area Number 19590090
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biological pharmacy
Research InstitutionDoshisha Women's College of Liberal Arts

Principal Investigator

MATSUNO Hiroyuki  Doshisha Women's College of Liberal Arts, 薬学部, 教授 (40273148)

Co-Investigator(Kenkyū-buntansha) WADA Kahon  同志社女子大学, 薬学部, 准教授 (00314427)
黒木 綾  同志社女子大学, 薬学部, 助手 (50411088)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsplasmin / uPAR / adipocyte / migration / proliferation / antiplasmin / TGF-beta / fibrosis / ATPase / alpha2-antiplasmin
Research Abstract

21世紀を迎え、我国の食生活や環境は欧米化というよりむしろ新たな独自性をもった日本スタイルを生み出していると考えられる。このような状況下で、本研究は脂肪細胞の分化・誘導に関して新しい観点から線溶系因子の関与ならびに発生学的に重要なプロトンポンプの意義について探求した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (18 results)

All 2008 2007

All Journal Article (14 results) (of which Peer Reviewed: 7 results) Presentation (4 results)

  • [Journal Article] The absence of uPAR attenuates insulin-induced vascular smooth muscle cell migration and proliferation2008

    • Author(s)
      Kanno Y, Kuroki A, Minamida M, Kaneiwa A, Okada K, Tomogane K, Takeuchi K, Ueshima S, Matsuo O, Matsuno H.
    • Journal Title

      Thromb Res 123(2)

      Pages: 336-41

    • Related Report
      2008 Final Research Report
  • [Journal Article] The absence of uPAR is associated with the progression of dermal fibrosis2008

    • Author(s)
      Kanno Y, Kaneiwa A, Minamida M, Kanno M, Tomogane K, Takeuchi K, Okada K, Ueshima S, Matsuo O, Matsuno H.
    • Journal Title

      J Invest Dermatol 128(12)

      Pages: 2792-7

    • Related Report
      2008 Final Research Report
  • [Journal Article] Defective assembly of a hybrid vacuolar H(+)-ATPase containing the mouse testis-specific E1 isoform and yeast subunits2008

    • Author(s)
      Hayashi K, Sun-Wada GH, Wada Y, Nakanishi-Matsui M, Futai M.
    • Journal Title

      Biochim Biophys Acta. 1777(10)

      Pages: 1370-7

    • Related Report
      2008 Final Research Report
  • [Journal Article] Vacuolar-type H(+)-ATPase with the a3 isoform is the proton pump on premature melanosomes2008

    • Author(s)
      Tabata H, Kawamura N, Sun-Wada GH, Wada Y.
    • Journal Title

      Cell Tissue Res. 332(3)

      Pages: 447-60

    • Related Report
      2008 Final Research Report
  • [Journal Article] Vacuolar-type proton ATPase as regulator of membrane dynamics in multicellular organisms2008

    • Author(s)
      Wada Y, Sun-Wada GH, Tabata H, Kawamura N.
    • Journal Title

      J Bioenerg Biomembr. 40(1)

      Pages: 53-7

    • Related Report
      2008 Final Research Report
  • [Journal Article] The absence of uPAR attenuates insulin-induced vascular smooth muscle cell migration and proliferation.2008

    • Author(s)
      Kanno Y
    • Journal Title

      Thromb Res. 123

      Pages: 336-341

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The absence of uPAR is associated with the progression of dermal fibrosis2008

    • Author(s)
      Kanno Y
    • Journal Title

      J Invest Dermatol. 128

      Pages: 2792-2797

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vacuolar-type H(+)-ATPase with the a3 isoform is the proton pump on premature melanosomes.2008

    • Author(s)
      Tabata H
    • Journal Title

      Cell Tissue Res. 332

      Pages: 447-460

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Vacuolar-type proton ATPase as regulator of membrane dynamics in multicellular organisms.2008

    • Author(s)
      Wada Y
    • Journal Title

      J Bioenerg Biomembr. 40

      Pages: 53-57

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alpha2-antiplasmin is involved in the production of transforming growth factor beta1 and fibrosis2007

    • Author(s)
      Kanno Y, Kuroki A, Okada K, Tomogane K, Ueshima S, Matsuo O, Matsuno H.
    • Journal Title

      J Thromb Haemost. 5(11)

      Pages: 2266-73

    • Related Report
      2008 Final Research Report
  • [Journal Article] Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues2007

    • Author(s)
      Sun-Wada GH, Tabata H, Kawamura N, Futai M, Wada Y.
    • Journal Title

      Cell Tissue Res. 329(2)

      Pages: 239-48

    • Related Report
      2008 Final Research Report
  • [Journal Article] Alpha2-antiplasmin is involved in the production of transforming growth factor betal and fibrosis.2007

    • Author(s)
      Kannno H.
    • Journal Title

      J.Thromb.Haemost. 5

      Pages: 2266-2273

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase …2007

    • Author(s)
      Sun-Wada GH.
    • Journal Title

      Cell Tissue Res. 329

      Pages: 239-248

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of staphylokinase-derived nonadecapeptide on the activation of plasminogen.2007

    • Author(s)
      Okada Y.
    • Journal Title

      Thromb.Haemost. 97

      Pages: 795-802

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 脂肪組織形成におけるuPARの新たな役割の探求2008

    • Organizer
      第31回日本血栓止血学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Fibrinolytic factors play pivotal roles on the development of metabolic diseases2008

    • Organizer
      第31回日本血栓止血学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-20
    • Related Report
      2008 Final Research Report
  • [Presentation] uPAR欠損における血管平滑筋細胞の遊走と増殖の効果2007

    • Organizer
      第30回分子生物学会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 線維化における線維素溶解因子AP2の役割2007

    • Organizer
      第30回日本血栓止血学会
    • Place of Presentation
      志摩
    • Year and Date
      2007-11-15
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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