Investigation of fibrinolytic system on differentiation of adipocytes and establishment of therapeutic strategy

• Project/Area Number: 19590090
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biological pharmacy
• Research Institution: Doshisha Women's College of Liberal Arts
• Principal Investigator: MATSUNO Hiroyuki Doshisha Women's College of Liberal Arts, 薬学部, 教授 (40273148)
• Co-Investigator(Kenkyū-buntansha): WADA Kahon 同志社女子大学, 薬学部, 准教授 (00314427) ; 黒木 綾 同志社女子大学, 薬学部, 助手 (50411088)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: plasmin / uPAR / adipocyte / migration / proliferation / antiplasmin / TGF-beta / fibrosis / ATPase / alpha2-antiplasmin

Research Abstract

21世紀を迎え、我国の食生活や環境は欧米化というよりむしろ新たな独自性をもった日本スタイルを生み出していると考えられる。このような状況下で、本研究は脂肪細胞の分化・誘導に関して新しい観点から線溶系因子の関与ならびに発生学的に重要なプロトンポンプの意義について探求した。

Research Products

• [Journal Article] The absence of uPAR attenuates insulin-induced vascular smooth muscle cell migration and proliferation (2008)
  • Author(s): Kanno Y, Kuroki A, Minamida M, Kaneiwa A, Okada K, Tomogane K, Takeuchi K, Ueshima S, Matsuo O, Matsuno H.
  • Journal Title: Thromb Res 123(2) Pages: 336-41
• [Journal Article] The absence of uPAR is associated with the progression of dermal fibrosis (2008)
  • Author(s): Kanno Y, Kaneiwa A, Minamida M, Kanno M, Tomogane K, Takeuchi K, Okada K, Ueshima S, Matsuo O, Matsuno H.
  • Journal Title: J Invest Dermatol 128(12) Pages: 2792-7
• [Journal Article] Defective assembly of a hybrid vacuolar H(+)-ATPase containing the mouse testis-specific E1 isoform and yeast subunits (2008)
  • Author(s): Hayashi K, Sun-Wada GH, Wada Y, Nakanishi-Matsui M, Futai M.
  • Journal Title: Biochim Biophys Acta. 1777(10) Pages: 1370-7
• [Journal Article] Vacuolar-type H(+)-ATPase with the a3 isoform is the proton pump on premature melanosomes (2008)
  • Author(s): Tabata H, Kawamura N, Sun-Wada GH, Wada Y.
  • Journal Title: Cell Tissue Res. 332(3) Pages: 447-60
• [Journal Article] Vacuolar-type proton ATPase as regulator of membrane dynamics in multicellular organisms (2008)
  • Author(s): Wada Y, Sun-Wada GH, Tabata H, Kawamura N.
  • Journal Title: J Bioenerg Biomembr. 40(1) Pages: 53-7
• [Journal Article] The absence of uPAR attenuates insulin-induced vascular smooth muscle cell migration and proliferation. (2008)
  • Author(s): Kanno Y
  • Journal Title: Thromb Res. 123 Pages: 336-341
  • Peer Reviewed
• [Journal Article] The absence of uPAR is associated with the progression of dermal fibrosis (2008)
  • Author(s): Kanno Y
  • Journal Title: J Invest Dermatol. 128 Pages: 2792-2797
  • Peer Reviewed
• [Journal Article] Vacuolar-type H(+)-ATPase with the a3 isoform is the proton pump on premature melanosomes. (2008)
  • Author(s): Tabata H
  • Journal Title: Cell Tissue Res. 332 Pages: 447-460
  • Peer Reviewed
• [Journal Article] Vacuolar-type proton ATPase as regulator of membrane dynamics in multicellular organisms. (2008)
  • Author(s): Wada Y
  • Journal Title: J Bioenerg Biomembr. 40 Pages: 53-57
  • Peer Reviewed
• [Journal Article] Alpha2-antiplasmin is involved in the production of transforming growth factor beta1 and fibrosis (2007)
  • Author(s): Kanno Y, Kuroki A, Okada K, Tomogane K, Ueshima S, Matsuo O, Matsuno H.
  • Journal Title: J Thromb Haemost. 5(11) Pages: 2266-73
• [Journal Article] Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase in mouse endocrine tissues (2007)
  • Author(s): Sun-Wada GH, Tabata H, Kawamura N, Futai M, Wada Y.
  • Journal Title: Cell Tissue Res. 329(2) Pages: 239-48
• [Journal Article] Alpha2-antiplasmin is involved in the production of transforming growth factor betal and fibrosis. (2007)
  • Author(s): Kannno H.
  • Journal Title: J.Thromb.Haemost. 5 Pages: 2266-2273
  • Peer Reviewed
• [Journal Article] Differential expression of a subunit isoforms of the vacuolar-type proton pump ATPase … (2007)
  • Author(s): Sun-Wada GH.
  • Journal Title: Cell Tissue Res. 329 Pages: 239-248
  • Peer Reviewed
• [Journal Article] Effect of staphylokinase-derived nonadecapeptide on the activation of plasminogen. (2007)
  • Author(s): Okada Y.
  • Journal Title: Thromb.Haemost. 97 Pages: 795-802
  • Peer Reviewed
• [Presentation] 脂肪組織形成におけるuPARの新たな役割の探求 (2008)
  • Organizer: 第31回日本血栓止血学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-20
• [Presentation] Fibrinolytic factors play pivotal roles on the development of metabolic diseases (2008)
  • Organizer: 第31回日本血栓止血学会
  • Place of Presentation: 大阪
  • Year and Date: 2008-11-20
• [Presentation] uPAR欠損における血管平滑筋細胞の遊走と増殖の効果 (2007)
  • Organizer: 第30回分子生物学会
  • Place of Presentation: 横浜
  • Year and Date: 2007-12-11
• [Presentation] 線維化における線維素溶解因子AP2の役割 (2007)
  • Organizer: 第30回日本血栓止血学会
  • Place of Presentation: 志摩
  • Year and Date: 2007-11-15