Synthesis and evaluation of new α-glucosidase inhibitors having thiosugar-sulfonium salt structure based on salacinol
| Project/Area Number |
19590111
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Drug development chemistry
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| Research Institution | Kinki University |
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Principal Investigator |
TANABE Genzoh Kinki University, 薬学部, 准教授 (40217104)
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| Co-Investigator(Kenkyū-buntansha) |
MINEMATSU Toshie 近畿大学, 薬学部, 助手 (60088151)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | α-グルコシダーゼ阻害剤 / サラシノール / salacinol / Salacia reticalata / 糖尿病治療薬 / スルホニウム硫酸分子内塩 / 環状硫酸エステル / カップリング反応 / チオ糖 / Salacia reticulata |
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| Research Abstract |
Salacinol (1) is a potent glycosidase inhibitor isolated from Ayurvedic medicine (Salacia reticulata), which is traditionally used for the treatment of diabetes in Sri Lanka and India. In order to determine the effect of 5 membered thiosugar-sulfonium ring structure of 1 on α-glucosidase inhibition, several seco-analogs of 1 were synthesized. Their evaluation as inhibitors indicated that 5 membered ring structure of 1 was essential for the potent inhibition.
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Report
(4 results)
Research Products
(2 results)
