Studies on the effect of nanoparticles on oral tolerance
| Project/Area Number |
19590129
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | Kobe Pharmaceutical University |
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Principal Investigator |
YOSHINO Shin Kobe Pharmaceutical University, 薬学部, 教授 (00260729)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | ナノ粒子 / 経口免疫寛容 / Th1 / Th2 / Th3 / サイトカイン / 抗原提示細胞 / 過敏症 |
|---|
| Research Abstract |
ナノ粒子酸化亜鉛の経口免疫寛容に与える影響について検討した。実験動物としてマウスを、また抗原として卵白アルブミン(OVA)を用い、経口免疫寛容はOVA を抗原免疫前に投与し、Th1、Th2、Th3 免疫応答を抗体およびサイトカインを指標に測定した。その結果、酸化亜鉛はTh2 およびTh3 経口免疫寛容には影響を与えなかったが、Th1 経口免疫寛容に対しては阻害傾向を示した。酸化亜鉛のようなナノ粒子はTh1免疫寛容系に影響を及ぼす可能性があるため、さらに詳細に検討する必要がある。
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Report
(3 results)
Research Products
(45 results)
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[Journal Article] Improvement of an efficient separation method for chemicals in diesel exhaust par ticles: analysis for nitrophenols. Environ.2008
Author(s)
Noya, Y., Mikami, Y., Taneda, S., Mori, Y., Yoshino, S., Kohno, S.
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Journal Title
Environ. Sci. Pollut. Res. Int. 15
Pages: 318-321
Related Report
Peer Reviewed
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[Journal Article] Antioxidative role of interleukin-6 in septic lung injury in mice.2008
Author(s)
Inoue, K., Takano, H., Yanagisawa, R., Sakurai, M., Yoshino, S., Yoshikawa, T.
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Journal Title
Int. J. Immunopathol. 21
Pages: 501-508
Related Report
Peer Reviewed
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[Journal Article] Polycyclic aromatic hydrocarbons aggravate antigen-induced nasal blockage in experimental allergic rhinitis.2007
Author(s)
Mizutani, N., Nabe, T., Ohtani, Y., Fujii, M., Yoshino, S., Kohno, S.
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Journal Title
J. Pharamacol. Sci. 105
Pages: 291-297
NAID
Related Report
Peer Reviewed
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[Journal Article] Pulmonary exposure to diesel exhaust particle components enhaces circulatory chemokines during lung inflammation.2007
Author(s)
Arimoto, T., Takano, H., Inoue, K., Yanagisawa, R., Yoshino, S., Yoshikawa, T.
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Journal Title
Int. J. Immunopathol. Pharmacol. 20
Pages: 197-201
Related Report
Peer Reviewed
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[Journal Article] Effects of nanoparticles on lung physiology in the presence or absence of antigen.2007
Author(s)
Inoue, K., Takano, H., Yanagisawa, R., Sakurai, M., Yoshino, S., Yoshikawa, T.
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Journal Title
Int. J. Immunopathol. Pharmacol. 20
Pages: 737-744
Related Report
Peer Reviewed
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[Journal Article] Effects of components derived from diesel exhaust particles on lung physiology related to antigen.2007
Author(s)
Inoee, K., Takano, H., Yanagisawa, R., Sakurai, M, Shimada, A., Yoshino, S., Yoshikawa, T.
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Journal Title
Immunopharmacol. Immunotoxicol. 29
Pages: 403-412
Related Report
Peer Reviewed
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