Hyperesthesia via the alteration of thermo-sensitive TRP channels in animal model of irritable bowel syndrome
| Project/Area Number |
19590156
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Josai International University |
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Principal Investigator |
HORIE Syunji Josai International University, 薬学部, 教授 (50209285)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | TRPV1 / カプサイシン / TRPA1 / アリルイソチオシアネート / 下部消化管 / 内臓知覚神経 / 免疫組織化学 / ストレス / 消化管機能 / CGRP / 知覚過敏 / TRPVJ / TRPAJ / 内臟知覚神経 |
|---|
| Research Abstract |
精神的ストレスが積み重なると、消化管に大きな影響を与え、便通異常と痛みを伴う過敏性腸症候群というやっかいな病気に進展する。この原因を解明するために、過敏性腸症候群モデル動物を用いた研究を行った。結果として、ストレスにより消化管に知覚過敏が引き起こされており、これにはカプサイシン受容体TRPV1(43℃の熱で活性化するセンサー)の反応性が大きくなっていることが判明した。したがって、このカプサイシン受容体は新しい医薬品のターゲットになると考えている。
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Report
(3 results)
Research Products
(47 results)
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[Journal Article] Localization of TRPV1 and contractile effect of capsaicin in mouse large intestine: high abundance and sensitivity in rectum and distal colon.2009
Author(s)
Matsumoto, K., Kurosawa, E., Terui, H., Hosoya, T., Tashima, K., Murayama, T., Priestley, J.V., Horie, S.
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Journal Title
Am. J. Physiol. Gastrointest. Liver Physiol. (in press)
Related Report
Peer Reviewed
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[Journal Article] Validation of 13C-acetic acid breath test by measuring effects of loperamide, morphine, mosapride, and itopride on gastric emptying in mice.2008
Author(s)
Matsumoto, K., Kimura, H., Tashima, K., Uchida, M., Horie, S.
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Journal Title
Biol. Pharm. Bull. 31(10)
Pages: 1917-1922
Related Report
Peer Reviewed
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[Journal Article] The Chemical Constituents of Aristolochia constricta: Antispasmodic effects of its constituents in guinea-pig ileum and isolation of a diterpeno-lignan hybrid.2008
Author(s)
Zhang, G., Shimokawa, S., Mochizuki, M., Kumamoto, T., Nakanishi, W., Watanabe, T., Ishikawa, T., Matsumoto, K., Tashima, K., Horie, S., Higuchi, Y., Dominguez, O.P.
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Journal Title
J. Natural Products 71
Pages: 1167-1172
Related Report
Peer Reviewed
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[Journal Article] Immunohistochemical localization of transient receptor potential vanilloid subtype 1 in the trachea of ovalbumin-sensitized guinea pigs.2008
Author(s)
Watanabe, N., Horie, S., Spina, D., Michael, G.J., Page, C.P., Priestley, J.V.
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Journal Title
International Archives of Allergy and Immunology 146(1)
Pages: 28-32
Related Report
Peer Reviewed
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[Journal Article] MGM-9 [(E)-methyl 2-(3-ethyl-7a,12a-(epoxyethanoxy)-9-fluoro-1,2,3,4,6,7,12,12b-octahydro-8-methoxyindolo[2,3-a]quinolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine: a novel dual-acting μ- and κ-opioid agonist with potent antinociceptive and weak rewarding effects in mice.2008
Author(s)
Matsumoto, K., Takayama, H., Narita, M., Nakamura, A., Suzuki, M., Suzuki, T., Murayama, T., Wongseripipatana, S., Misawa, K., Kitajima, M., Tashima, K., Horie, S.
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Journal Title
Neuropharmacology 55(2)
Pages: 154-165
Related Report
Peer Reviewed
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[Journal Article] MGM-9[(E)-methyl 2-(3-ethyl-7a, 12a-(epoxyethanoxy)-9-fluoro-1, 2, 3, 4, 6, 7, 12, 12b- octahydro-8-methoxyindolo[2, 3-a]qulnolizin-2-yl)-3-methoxyacrylate], a derivative of the indole alkaloid mitragynine : a novel dual-acting μ-and κ-opioid agonist with potent antinociceptive and weak rewarding effects in mice2008
Author(s)
Matsumoto, K.
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Journal Title
Neuropharmacology 55
Pages: 154-165
Related Report
Peer Reviewed
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[Journal Article] Contractile effect of TRPA1 receptor agonists in the isolated mouse intestine. Eur.2007
Author(s)
Penuelas, A, Tashima, K., Tsuchiya, S., Matsumoto, K., Nakamura, T., Horie, S., Yano, S.
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Journal Title
J. Pharmacol. 576(1-3)
Pages: 143-50
Related Report
Peer Reviewed
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[Journal Article] Quercetin-induced PC12 cell death accompanied by caspase-mediated DNA fragmentation.2007
Author(s)
Sasaki, M., Nakamura, H., Tsuchiya, S., Horie, S., Kashiwayanagi, M., Saito, T., Murayama, T.
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Journal Title
Biol. Pharm. Bull. 30(4)
Pages: 682-686
Related Report
Peer Reviewed
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