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Identification and Functional Characterization of Pyrilamine Transporter, an Organic Cation Transporter

Research Project

Project/Area Number 19590161
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionTeikyo University

Principal Investigator

DEGUCHI Yoshlharu  Teikyo University, 薬学部, 教授 (40254255)

Co-Investigator(Kenkyū-buntansha) 黄倉 崇  帝京大学, 薬学部, 講師 (80326123)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords薬物動態学 / 血液脳関門 / 有機カチオントランスポーター / 不死化細胞株 / ピリラミン / PAMT / トランスポーター / 有機カチオン性物質 / モノアミン / PMAT / TR-BBB13 / siRNA / 有機カチオン性薬物 / OCTN2
Research Abstract

本研究課題は、血液脳関門(BBB)における有機カチオン輸送系ピリラミントランスポーターの分子実体の解明と輸送特性を明らかにすることを目的とした。本研究において、研究代表者は分子実体と輸送機能が異なる2つの有機カチオン性トランスポーターがBBBで機能していることを明らかにした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (30 results)

All 2009 2008 2007

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (21 results) Book (3 results)

  • [Journal Article] Involvement of the pyrilamine transporter, a putative organic cation transporter, in blood-brain barrier transport of oxycodone2008

    • Author(s)
      Okura T, Hattori A, Takano Y, Sato T, Hammarlund-Udenaes M, Terasaki T, Deguchi Y.
    • Journal Title

      Drug Metab. Dispos 36

      Pages: 2005-2005

    • Related Report
      2008 Final Research Report
  • [Journal Article] Involvement of the pyrilamine transporter, a putative organic cationtransporter, in blood-brain barrier transport of oxycodone.2008

    • Author(s)
      Okura T, Deguchi Y, et al.
    • Journal Title

      Drug Metab. Dispos. 36

      Pages: 2005-2013

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood-brain barrier transport of pramipexole, a dopamine D2 agonist2007

    • Author(s)
      Okura T. Ito R, Ishiguro N, Tamai I, Deguchi Y.
    • Journal Title

      Life Sci. 80

      Pages: 1564-1564

    • Related Report
      2008 Final Research Report
  • [Journal Article] Comparative evaluation of antinociceptive potency of morphine and morphine-6ss-glucuronide by simultaneous measurements of spinal concentration2007

    • Author(s)
      Okura T, Komiyama N, Morita Y, Deguchi Y, Yamada S.
    • Journal Title

      Life Sci 80

      Pages: 1319-1319

    • Related Report
      2008 Final Research Report
  • [Journal Article] Comparative measurement of spinal CSF microdialysate concentrations and concomitant antinociception of morphine and morphine-6b-glucuronide in rats2007

    • Author(s)
      Okura T, Deguchi Y, et. al.
    • Journal Title

      Life Science 80

      Pages: 1319-1326

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blood-brain barrier transport of pramipexole, a dopamine D2 agonist2007

    • Author(s)
      Okura T, Deguchi Y, et. al.
    • Journal Title

      Life Science 80

      Pages: 1564-1571

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Drug-drug interactions between oxycodone and adjuvant analgesics at the blood-brain barrier2009

    • Author(s)
      Takashi Okura, Yusuke Nakazawa, Asami Hattori, Tetsuya Terasaki and Yoshiharu Deguchi
    • Organizer
      8th ISSX/22th JSSX Joint Meeting
    • Place of Presentation
      abstract
    • Related Report
      2008 Final Research Report
  • [Presentation] The pyrilamine transPorter functions as the multispecific organic cation transporter at the blood-brain barrier2008

    • Author(s)
      Keita Shimomura, Yoshiharu Deguchi et.al.
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-31
    • Related Report
      2008 Final Research Report
  • [Presentation] Plasma membrane monoamine trans- Porter(PMAT)mediates the efflux transport of org anic cations in the brain barrier system2008

    • Author(s)
      Takenori Sato, Yoshiharu Deguchi.et.al.
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-31
    • Related Report
      2008 Final Research Report
  • [Presentation] The pyrilamine transporter functions as the multispecific organic cation transporter at the blood-brain barrier2008

    • Author(s)
      Keita Shimomura, Yoshiharu Deguchi, et al
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Plasma membrane monoamine transporter (PMAT) mediates the efflux transport of organic cations in the brain barrier system2008

    • Author(s)
      Takenori Sato, Yoshiharu Deguchi, et al
    • Organizer
      第23回日本薬物動態学会年会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] Takashi Okllra Yoshiharu Deguchi et.al.2008

    • Author(s)
      Takashi Okllra Yoshiharu Deguchi et.al.
    • Organizer
      11^<th> International Symposium on Signal Transduction in the Blood-Brain Barrier
    • Place of Presentation
      オランダ・アムステルダム
    • Year and Date
      2008-09-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression and functional characterization of plasma membrane monoamine transporter(PMAT)in the rat BBB2008

    • Author(s)
      Yoshiharu Deguchi, et.al.
    • Organizer
      11^<th> International SymPosium on Signal Transduction in the Blood-Brain Barrier
    • Place of Presentation
      オランダ・アムステルダム
    • Year and Date
      2008-09-20
    • Related Report
      2008 Final Research Report
  • [Presentation] Blood-brain barrier transport and pharmacological effect of opioids2008

    • Author(s)
      Takashi Okura, Yoshiharu Deguchi, et al
    • Organizer
      11^<th> International Symposium on Signal Transduction in the Blood-Brain Barrier
    • Place of Presentation
      オランダ・アムステルダム
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] Expression and functional characterization of plasma membrane monoamine transporter (PMAT) in the rat blood-brain barrier2008

    • Author(s)
      Yoshiharu Deguchi, et al
    • Organizer
      11^<th> International Symposium on Signal Transduction in the Blood-Brain Barrier
    • Place of Presentation
      オランダ・アムステルダム
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] カチオントランスポーターPMATの脳関門における発現と輸送機能解析2008

    • Author(s)
      佐藤武則, 出口芳春, 他
    • Organizer
      日本薬剤学会第23年会
    • Place of Presentation
      札幌
    • Year and Date
      2008-05-20
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血液脳関門に高発現する新規有機カチオントランスポーター(PMAT)のクローニングと輸送機能解析2008

    • Author(s)
      高野祐輔、黄倉崇、出口芳春ら
    • Organizer
      日本薬学会第128年会
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-26
    • Related Report
      2008 Final Research Report
  • [Presentation] 脳関門におけるrat plasmame mebrane transporter(rPMAT)の発現と輸送機能2007

    • Author(s)
      高野祐輔、黄倉崇、出口芳春ら
    • Organizer
      トランスポーター研究会第1回関東部会
    • Place of Presentation
      横浜
    • Year and Date
      2007-12-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Blood-brain barrier transport of oxycodone, an opioid receptor agonist2007

    • Author(s)
      Asami Hattori, Takashi Okura, Yusuke Nakazawa Margareta Hammarlund-Udenaes, Tetsuya Terasaki, Yoshiharu Deguchi
    • Organizer
      The 5th International Symposium on Receptor Mechanisms, Signal Transduction and Drug Effects, Shizuoka p.95
    • Place of Presentation
      abstract form
    • Related Report
      2008 Final Research Report
  • [Presentation] 血液脳関門におけるカチオン性薬物トランスポーターの機能および輸送分子の解析2007

    • Author(s)
      出口芳春、黄倉崇、服部麻美、鈴木俊英、寺崎哲也
    • Organizer
      講演要旨集.p.405(2007)
    • Place of Presentation
      日本薬剤学会(大宮)
    • Related Report
      2008 Final Research Report
  • [Presentation] 麻薬性鎮痛薬オキシコドンと鎮痛補助薬の相互作用解析2007

    • Author(s)
      黄倉崇、中澤佑介、服部麻美、寺崎哲也、出口芳春
    • Organizer
      講演要旨集, p.343(2007)
    • Place of Presentation
      日本薬剤学会(大宮)
    • Related Report
      2008 Final Research Report
  • [Presentation] H+/organic cation antiporter is involved in the blood-brain barrier transport of cationic drugs2007

    • Author(s)
      Yoshiharu Deguchi, Takashi Okura, et.al.
    • Organizer
      4th World Conference on Drug Absorption, Transport and Delivery
    • Place of Presentation
      Kanazawa
    • Related Report
      2008 Final Research Report
  • [Presentation] Involvement of H+/organic cation antiporter in the blood-brain barrier transport of cationic drugs2007

    • Author(s)
      Yoshiharu Deguchi
    • Organizer
      10th International Symposium, Signal Transduction in the Blood-Brain Barrier
    • Place of Presentation
      Postdam/Germany
    • Related Report
      2008 Final Research Report
  • [Presentation] Expression and transport function of ratplasma membrane transporter(rPMAT)in the brain barrler system2007

    • Author(s)
      黄倉崇、出口芳春ら
    • Organizer
      第29回生体膜と薬物の相互作用シンポジウム
    • Place of Presentation
      仙台
    • Related Report
      2008 Final Research Report
  • [Presentation] 血液脳関門におけるカチオン性薬物トランスポーターの機能および輸送分子の解析2007

    • Author(s)
      出口 芳春, ら
    • Organizer
      日本薬剤学会
    • Place of Presentation
      大宮
    • Related Report
      2007 Annual Research Report
  • [Presentation] H+/organic cation antiporter is involved in the blood-brain barrier transport of cationic drugs2007

    • Author(s)
      Deguchi Y, et. al.
    • Organizer
      4th World Conference on Drug Absorption, Transport and Delivery
    • Place of Presentation
      金沢
    • Related Report
      2007 Annual Research Report
  • [Presentation] Involvement of H+/0rganic cation antiporter in the blood-brain barrier transport of cationic drugs2007

    • Author(s)
      Deguchi Y
    • Organizer
      10th International Symposium, Signal Transduction in the Blood-Brain Barrier
    • Place of Presentation
      Postdam/Germany
    • Related Report
      2007 Annual Research Report
  • [Book] 血液脳関門トランスポーターと創薬、トランスポーター科学の最前線、(辻彰編)2008

    • Author(s)
      出口芳春
    • Total Pages
      119
    • Related Report
      2008 Final Research Report
  • [Book] 分布(辻彰編)2007

    • Author(s)
      出口芳春
    • Total Pages
      98
    • Publisher
      南江堂
    • Related Report
      2008 Final Research Report
  • [Book] トランスポーター科学最前線2007

    • Author(s)
      出口 芳春
    • Total Pages
      15
    • Publisher
      京都廣川書店
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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