Molecular mechanisms for resistance to immunosuppressive drugs in human lymphocytes stimulated with bacterial superantigen and the effects of antibiotics.
| Project/Area Number |
19590162
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical pharmacy
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
HIRANO Toshihiko Tokyo University of Pharmacy and Life Science, 薬学部, 教授 (90173252)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUNO Naoto 東京医科大学, 医学部, 准教授 (00231598)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2007: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | スーパー抗原 / 末梢血リンパ球 / 免疫抑制薬 / 薬物耐性機序 / 抗菌薬 / ヒト末梢血単核細胞 / インターロイキンー2 / 溶血性連鎖球菌 / カテプシン / ペプスタチン / ロキシスロマイシン / 免疫抑制薬耐性の分子機序 / インターロイキン-2 / ビタミンD3誘導体 / グルココルチコイド / MAPキナーゼ / JNK |
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| Research Abstract |
Immunosuppressive drugs are used for treatment of several autoimmune diseases, whereas some of the patients are known to show resistance to the therapeutic efficacy of the drugs. I showed in the present study that superantigen produced from infectious bacteria aggressively stimulate immune cells, which results in production of high amount of interleukin-2 (IL-2) and the drug resistance. I also found that roxithromycin can suppress the IL-2 production from superantigen-stimulated immune cells, and therefore the drug may overcome clinical resistance to immunosuppressive drugs in patients with autoimmune diseases having bacterial infection.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Pharmacodynamic parameters of immunosuppressive drugs are not correlated with age, duration of dialysis, percentage of lymphocytes or lymphocyte stimulation index in renal transplant recipients.2008
Author(s)
Sugiyama K, Isogai K, Toyama A, Satoh H, Saito K, Nakagawa Y, Tasaki M, Takahashi K, Saito N, Hirano T
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Journal Title
Biol Pharm Bull 31(11)
Pages: 2146-2149
NAID
Related Report
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