Molecular and morphological analysis on the physiological significance of sex steroid synthesis in the thyroid gland

• Project/Area Number: 19590177
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Wakayama Medical University
• Principal Investigator: TSURUO Yoshihiro Wakayama Medical University, 医学部, 教授 (90207449)
• Co-Investigator(Kenkyū-buntansha): UEYAMA Takashi 和歌山県立医科大学, 医学部, 准教授 (50264875) ; ITO Takao 和歌山県立医科大学, 医学部, 助教 (30315931)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: ステロイド代謝酵素 / 性ステロイド / 甲状腺 / 濾胞上皮細胞 / 傍濾胞細胞 / 形態学

Research Abstract

甲状腺ホルモン(サイロキシン : T4、トリヨードサイロニン : T3)とカルシトニンの甲状腺での合成と分泌は、他のステロイド標的器官と同様に、生殖腺から分泌され血行性に到達する性ステロイドによって調節されるものと信じられていた。しかし我々は今回の研究で甲状腺内に性ステロイド代謝酵素が発現することを確認し、甲状腺ホルモンが甲状腺内で合成される性ステロイドによって機能調節される可能性を見出した。

Research Products

• [Journal Article] Adaptive HNE-Nrf2-HO1 pathway against oxidative stress is associated with acute gastric mucosal lesions (2008)
  • Author(s): Ueda K, Ueyama T, Yoshida K, Kimura H, Ito T, Shimizu Y, Oka M, Tsuruo Y, Ichinose M
  • Journal Title: Am J Physiol 295
• [Journal Article] Catecholamines and estrogen are involved in the pathogenesis of emotional stress-induced acute heart attack (2008)
  • Author(s): Ueyama T, Kasamatsu K, Hano T, Tsuruo Y, Ishikura F
  • Journal Title: Ann NY Acad Sci 1148 Pages: 479-480
  • Peer Reviewed
• [Journal Article] エストロゲンは心血管系と神経系とに作用し、情動的ストレスとカテコラミンで誘発される急性心不全を改善する (2008)
  • Author(s): 上山敬司, 鶴尾吉宏, 石蔵文信
  • Journal Title: 自律神経 45 Pages: 98-100
  • NAID: 10024485896
• [Journal Article] Adaptive HNE-Nrf2-H01 pathway against oxidative stress is as sociated with acute gastric mucosal lesions. (2008)
  • Author(s): Ueda K, et al.
  • Journal Title: Am J Physiol 295
  • Peer Reviewed
• [Journal Article] Catecholamines and estrogen are involved in the pathogenesis of emotional stress-induced acute heart attack. (2008)
  • Author(s): Ueyama T, et al.
  • Journal Title: Ann NY Acad Sci 1148 Pages: 479-480
  • Peer Reviewed
• [Journal Article] エストロゲンは心血管系と神経系とに作用し、情動的ストレスとカテコラミンで誘発される急性心不全を改善する. (2008)
  • Author(s): 上山敬司ら
  • Journal Title: 自律神経 45 Pages: 98-100
  • NAID: 10024485896
• [Journal Article] Chronic estrogen supplementation following ovariectomy improves the emotional stress-induced cardiovascular responses by indirect action on the nervous system and by direct action on the heart (2007)
  • Author(s): Ueyama T, Ishikura F, Matsuda A, Asanuma T, Ueda K, Ichinose M, Kasamatsu K, Hano T, Akasaka T, Tsuruo Y, Morimoto K, Beppu S
  • Journal Title: Circ J 71 Pages: 565-573
  • NAID: 110006272149
  • Peer Reviewed
• [Journal Article] Chronic estrogen supplementation following ovariectomy improves the emotional stress-induced cardiovascular responses by indirect action on the nervous system and by direct action on the heart (2007)
  • Author(s): Ueyama T, et. al.
  • Journal Title: Circ J 71 Pages: 565-573
  • NAID: 110006272149
  • Peer Reviewed
• [Presentation] たこつぼ心筋症モデルにおける、ヘムオキシゲナーゼの増加 (2008)
  • Author(s): 上山敬司, 鶴尾吉宏
  • Organizer: 第61回日本自律神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-11-07
• [Presentation] たこつぼ心筋症モデルにおける、ヘムオキシゲナーゼの増加. (2008)
  • Author(s): 上山敬司ら
  • Organizer: 第61回日本自律神経学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2008-11-07
• [Presentation] PolaprezincによるHO-1誘導作用 (2008)
  • Author(s): 上田和樹, 上山敬司, 岡政志, 鶴尾吉宏,一瀬雅夫
  • Organizer: 第50回日本消化器病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-01
• [Presentation] PolaprezincによるHO-1誘導作用. (2008)
  • Author(s): 上田和樹ら
  • Organizer: 第50回日本消化器病学会
  • Place of Presentation: 東京
  • Year and Date: 2008-10-01
• [Presentation] 情動的ストレス誘発心不全におけるヘムオキシゲナーゼの増加 (2008)
  • Author(s): 上山敬司, 伊藤隆雄, 鶴尾吉宏
  • Organizer: 第113回日本解学会総会
  • Place of Presentation: 大分
  • Year and Date: 2008-03-29
• [Presentation] Surge of catecholamines and reduction of estrogen trigger the emotional stress-induced acute cardiac dysfunction in human and in rat (2007)
  • Author(s): Ueyama T, Tsuruo Y, Akashi YJ
  • Organizer: Satellite symposium of 5th congress of the international society for autonomic neuroscience
  • Place of Presentation: Wakayama, Japan
  • Year and Date: 2007-10-03
• [Presentation] Surge of catecholamines and reduction of estrogen trigger the emotional stress-induced acute cardiac dysfunction in human and in rat. (2007)
  • Author(s): Ueyama T, et. al.
  • Organizer: Satellite symposium of 5th congress of the international society for autonomic neuroscience
  • Place of Presentation: Wakayama,Japan
  • Year and Date: 2007-10-03
• [Presentation] Estrogen modulates the emotional stress- and catecholamine-induced acute heart failure (2007)
  • Author(s): 4. Ueyama T, Tsuruo Y
  • Organizer: 5th congress of the international society for autonomic neuroscience
  • Place of Presentation: Kyoto, Japan
• [Presentation] Catecholamine and estrogen are involved in the pathogenesis of stress-induced acute heart attack (2007)
  • Author(s): Ueyama T, Tsuruo Y, Ishikura F
  • Organizer: 9th symposium on catecholamines and other neurotransmitters in stress
  • Place of Presentation: Smolenice Castle,S lovakia
• [Presentation] Catecholamine and estrogen are involved in the pathogenesis of stress-induced acute heart attack. (2007)
  • Author(s): Ueyama T, et. al.
  • Organizer: 9th symposium on catecholamines and other neurotransmitters in stress
  • Place of Presentation: Smolenice Castle,Slovakia
• [Presentation] Estrogen modulates the emotional stress-and catecholamine-induced acute heart failure. (2007)
  • Author(s): Ueyama T, Tsuruo Y
  • Organizer: 5th congress of the international society for autonomic neuroscience
  • Place of Presentation: Kyoto,Japan