Investigation of coronary apoptosis by three dimensional imaging by automatic separation method for coronary arterioles and venules

• Project/Area Number: 19590182
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Kawasaki Medical School
• Principal Investigator: NEISHI Yoji Kawasaki Medical School, 医学部, 講師 (80319946)
• Co-Investigator(Kenkyū-buntansha): 豊田 英嗣 川崎医科大学, 医学部, 講師 (30248215) ; 前浜 智子 川崎医科大学, 医学部, 助教 (90435016)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 冠微小循環 / アポトーシス / 心筋虚血 / リモデリング / 三次元画像

Research Abstract

本研究では心筋虚血再灌流障害慢性期の冠血管アポトーシスの発症する病期おいて、冠微小血管の三次元構築が損壊されていく様相、血管構築の三次元空間的トポロジー、とりわけ冠細動脈と冠細静脈の三次元的相互的位置関係についての研究を行った。正常ラット心においてそのイメージングを行うことができたが、心筋虚血再灌流障害のラットモデルの慢性期心臓のサンプルを用いては同等のクオリティのイメージングを行うことは困難であった。

Research Products

• [Journal Article] Development of Cardiac Dysfunction Induced By Repetitive Transient Myocardial Ischemia Is Inhibited By Edaravone in Conscious Rats (2009)
  • Author(s): Toyota E, Neishi Y et al.
  • Journal Title: Clin Exp Pharmacol Physiol(2009 Mar 26.)
• [Journal Article] Novel rat model of ischemic cardiomyopathy induced by repetitive myocardial ischemia/reperfusion injury while conscious (2007)
  • Author(s): Toyota E, Neishi Y, et.al.
  • Journal Title: Circulation Journal 71(5) Pages: 788-795
  • NAID: 110006273621
• [Journal Article] Edaravone preserves coronary microvascular endothelial function after ischemia/reperfusion on the beating canine heart in vivo (2007)
  • Author(s): Sukmawan R, Toyota E, Neishi Y et.al.
  • Journal Title: J Pharmacol Sci 104(4) Pages: 341-348
  • NAID: 10024315221
• [Journal Article] Assessment of the histological characteristics of coronary arterial plaque with severe calcification (2007)
  • Author(s): Kume T, Toyota E, Neishi Y et.al.
  • Journal Title: Circulation Journal 71(5) Pages: 643-647
  • NAID: 110006273596
• [Journal Article] Novel rat model of ischemic cardiomyopathy induced by repetitive myocardial ischemia/reperfusion injury while conscious (2007)
  • Author(s): Toyota E, Neishi Y, et. al.
  • Journal Title: Circ J 71(5) Pages: 788-795
  • NAID: 110006273621
  • Peer Reviewed
• [Journal Article] Edaravone preserves coronary microvascular endothelial function after is chemia/reperfusion on the beating canille heart in vivo (2007)
  • Author(s): Sukmawan R, Toyota E, Neishi Y, et. al.
  • Journal Title: J Pharmacol Sci 104(4) Pages: 341-348
  • Peer Reviewed
• [Journal Article] Assessment of the histological characteristics of coronary arterial plaque with severe calcification (2007)
  • Author(s): Kume T, Toyota E, Neishi Y, et. al.
  • Journal Title: Circ J. 71(5) Pages: 643-647
  • NAID: 110006273596
  • Peer Reviewed
• [Journal Article] Development of Cardiac Dysfunction Induced by Repetitive Transient Myocardial Ischemia is Inhibited by Edaravone in Conscious Rats
  • Author(s): Toyota E, Neishi Y, et. al
  • Journal Title: Clin Exp Pharmacol Physiol (In press)
  • Peer Reviewed
• [Journal Article] Myocardial Deformation in Microscopic Area in Vivo Beating Heart
  • Author(s): Toyota, et al.
  • Journal Title: Kawasaki Medical Journal (In press)
• [Presentation] Renal Flow Reserve and Renal Resistance Index after Successful Percutaneous Renal Angioplasty for Renal Artery Stenosis Predict Renal Functional Recovery (2009)
  • Author(s): 根石陽二
  • Organizer: 日本循環器病学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] Renal Flow Reserve and Renal Resistance Index after Successful Percutaneous Renal Angioplasty for Renal Artery stenosis Predict Renal Functional Recovery (2009)
  • Author(s): Neishi Y, et al
  • Organizer: 日本循環器病学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2009-03-22
• [Presentation] 経皮的腎動脈形成術前後でのRenal Flow Reserveの変化と治療効果との関連 (2009)
  • Author(s): 根石陽二
  • Organizer: 心血管画像動態学会
  • Place of Presentation: 和歌山
  • Year and Date: 2009-01-17
• [Presentation] Renal Flow Reserve after Successful Percutaneous Renal (2008)
  • Author(s): 根石陽二
  • Organizer: Angioplasty predicts renal functional recovery American Heart Association
  • Place of Presentation: New Orleans
  • Year and Date: 2008-11-13
• [Presentation] Renal Flow Reserve after Successful Percutaneous Renal Angioplasty predicts renal functional recovery (2008)
  • Author(s): Neishi Y, et al
  • Organizer: American Heart Association
  • Place of Presentation: New Orleans
  • Year and Date: 2008-11-13
• [Presentation] Relation between Renal Artery Plaque composition and the Distance from the ostium in Patients with Atherosclerotic Renal Artery Stenosis Using Vitural Histology IVUS (2008)
  • Author(s): 根石陽二
  • Organizer: Transcatheter Cardiovascular Therapeutics
  • Place of Presentation: Washington D.C.
  • Year and Date: 2008-10-15
• [Presentation] Relation between Renal Artery Plaque composition and the Distance from the ostium in Patients with Atherosclerotic Renal Artery stenosis Using Vitural Histology IVUS (2008)
  • Author(s): Neishi Y, et al
  • Organizer: Transcatheter Cardiovascular Therapeutics
  • Place of Presentation: Washington D. C.
  • Year and Date: 2008-10-15
• [Presentation] VH-IVUS Analysis of Renal Artery Lesions with Atherosclerotic Renal Artery Stenosis (2008)
  • Author(s): 根石陽二
  • Organizer: 日本循環器病学会総会
  • Place of Presentation: 福岡
  • Year and Date: 2008-03-22
• [Presentation] 三次元で観る冠微小循環の構築と血流動態 (2007)
  • Author(s): 豊田英嗣
  • Organizer: モレキュラーイメージングセミナー
  • Place of Presentation: 北海道
  • Year and Date: 2007-02-19
• [Presentation] 三次元で観る冠微小循環の構築と血流動態 (2007)
  • Author(s): 豊田 英嗣・根石 陽二
  • Organizer: モレキュラーイメージングセミナー
  • Place of Presentation: 北海道札幌市
  • Year and Date: 2007-02-19
• [Patent(Industrial Property Rights)] Micro-pneumatic snare (2008)
  • Inventor(s): Eiji Toyota
  • Industrial Property Rights Holder: LSU(USA), WilliamChilian
  • Filing Date: 2008-03-18
  • Acquisition Date: 2008
• [Patent(Industrial Property Rights)] Micro pneumatic snare (2008)
  • Inventor(s): Eiji Toyota William Chilian
  • Industrial Property Rights Holder: LSU(USA)
  • Filing Date: 2008-03-18
  • Overseas
• [Patent(Industrial Property Rights)] 微小循環構築血管種別選択的造影剤および造影方法 (2007)
  • Inventor(s): 豊田 英嗣
  • Industrial Property Rights Holder: 財)岡山県産業振興財団
  • Industrial Property Number: 2007-187598
  • Filing Date: 2007-07-18