ATP-evoked signals in glial nets associated with sensory devices : Their properties in propagation and coupling to functions

• Project/Area Number: 19590184
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Hokkaido University
• Principal Investigator: TAKAHASHI-IWANAGA Hiromi Hokkaido University, 大学院・医学研究科, 准教授 (30193759)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2007: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
• Keywords: 感覚神経終末 / 終末シュワン細胞 / カルシウム画像 / アデノシン5'三リン酸 / グリア / アデノシン5'-三リン酸 / プリン作動性信号 / カベオラ / ATP分解酵素

Research Abstract

皮膚感覚装置グリア細胞は分岐する突起で連絡し合い、軸索終末間に広がる網をなす。このグリアの細胞外ATP刺激に対するCa応答について、伝播の時空特徴と制御因子を明らかにするため、ラット髭の動き受容器、槍型終末分離標本の生理実験と信号関連分子の組織化学を行なった。各軸索終末に伴行するグリア突起は、局所ATP刺激に対し独自のCa信号を生成し得る機能単位であり、信号の突起内局在化への細胞外ATP分解酵素の貢献が示された。

Research Products

• [Journal Article] Cellular expression of a monocarboxylate transporter (MCT1) in the mammary gland and sebaceous gland of mice (2009)
  • Author(s): Takebe K, Nio-Kobayashi J, Takahashi-Iwanaga H, Yajima T, Iwanaga T
  • Journal Title: Histochem Cell Biol 131 Pages: 401-409
  • Peer Reviewed
• [Journal Article] Immunohistochemical localization of six galectin subtypes in the mouse digestive tract (2009)
  • Author(s): Nio-Kobayashi J, Takahashi-Iwanaga H, Iwanaga T
  • Journal Title: J Histochem Cytochem 57 Pages: 41-50
  • Peer Reviewed
• [Journal Article] Immunohistochemical localization of six galectin subtypes in the mouse digestive tract (2009)
  • Author(s): Nio-Kobayashi, J., et.al.
  • Journal Title: Journal of Histochemistry and Cytochemistry 57 Pages: 41-50
  • Peer Reviewed
• [Journal Article] Cellular expression of a monocarboxylate transporter (MCT1) in the mammary gland and sebaceous gland of mice (2009)
  • Author(s): Takebe, K., et.al.
  • Journal Title: Histochemistry and Cell Biology 131 Pages: 401-409
  • Peer Reviewed
• [Journal Article] Histochemical demonstration of monocarboxylate transporter in the perineurium of mice with special reference to GLUT1 (2008)
  • Author(s): Takebe K, Nio-Kobayashi J, Takahashi-Iwanaga H, Iwanaga T
  • Journal Title: Biomed Res 29 Pages: 297-306
  • Peer Reviewed
• [Journal Article] A dual system of intercellular calcium signaling in glial nets associated with lanceolate sensory endings in rat vibrissae (2008)
  • Author(s): Takahashi-Iwanaga H, Nio-Kobayashi J, Habara Y, Furuya K
  • Journal Title: J Comp Neurol 510 Pages: 68-78
  • Peer Reviewed
• [Journal Article] Cellular expression of a sodium-dependent mono- carboxylate transporter (Slc5a8) and the MCT family in the mouse kidney (2008)
  • Author(s): Yanase H, Takebe K, Nio-Kobayashi J, Takahashi-Iwanaga H, Iwanaga T
  • Journal Title: Histo- chem Cell Biol 130 Pages: 957-966
  • Peer Reviewed
• [Journal Article] A dual system of intercellular calcium signaling in glial nets associated with lanceolate sensory endings in rat vibrissae (2008)
  • Author(s): Takahashi-Iwanaga, H., et.al.
  • Journal Title: Journal of Comparative Neurology 510 Pages: 68-78
  • Peer Reviewed
• [Journal Article] Cellular expression of a sodium-dependent monocarboxylate transporter (Slc5a8) and the MCT family in the mouse kidney (2008)
  • Author(s): Yanase, H., et.al.
  • Journal Title: Histochemistry and Cell Biology 130 Pages: 957-966
  • Peer Reviewed
• [Journal Article] Curriculum vitae of intestinal intraepithelial T cells: their develop- mental and behavioral characteristics (2007)
  • Author(s): Ishikawa H, Naito T, Iwanaga T, Takahashi-Iwanaga H, Suematsu M, Hibi T, Nanno M
  • Journal Title: Immunol Rev 215 Pages: 154-165
  • Peer Reviewed
• [Journal Article] Abnormal taste perception in mice lacking the type 3 inositol 1,4,5-trisphosphate receptor (2007)
  • Author(s): Hisatsune C, Yasumatsu K, Takahashi-Iwanaga H, Ogawa N, Kuroda Y, Yoshida R, Ninomiya Y, Mikoshiba K
  • Journal Title: J Biol Chem 282 Pages: 37225-37231
  • Peer Reviewed
• [Journal Article] Abnormal taste perception in mice lacking the type 3 inositol 1, 4, 5-tris-phosphate receptor. (2007)
  • Author(s): Hisatsune, C., et. al.
  • Journal Title: Journal of Biological Chemistry 282 Pages: 37225-37231
  • Peer Reviewed
• [Journal Article] A dual system of intercellular calcium signaling in glial nets associated with lanceolate sensory endings in rat vibrissae.
  • Author(s): Takahashi-Iwanaga, H., et. al.
  • Journal Title: Journal of Comparative Neurology (掲載確定)
  • Peer Reviewed
• [Presentation] サル膵臓導管系介在部における水チャネルアクアポリン1の発現 (2009)
  • Author(s): 岩永ひろみ, 岩永敏彦
  • Organizer: 第114回日本解剖学会総会・全国学術集会
  • Place of Presentation: 岡山
  • Year and Date: 2009-03-29
• [Presentation] ラット頬ひげの槍型知覚終末におけるATPを介したグリア信号系 (2009)
  • Author(s): 岩永ひろみ
  • Organizer: 第113回日本解剖学会全国学術集会シンポジウム「皮膚・口腔領域における感覚研究の進展」
  • Place of Presentation: 由布
  • Year and Date: 2009-03-29
• [Presentation] ラット頬ひげの槍型知覚終末におけるATPを介したグリア信号系 (2008)
  • Author(s): 岩永 ひろみ
  • Organizer: 第113回 日本解剖学会総会・全国学術集会
  • Place of Presentation: 大分大学医学部
  • Year and Date: 2008-03-29
• [Presentation] 皮膚・結合組織の知覚終末グリア細胞におけるecto-ATPaseの局在とその役割について (2007)
  • Author(s): 岩永ひろみ
  • Organizer: 生理学研究所研究会「生体システム間境界領域におけるATP・アデノシン情報伝達の役割」
  • Place of Presentation: 岡崎
  • Year and Date: 2007-09-07
• [Remarks]
  • URL: http://www.med.hokudai.ac.jp/~anat-3w/kenkyu.htm