Spacio-temporal analysis of molecular sorting events in mammalian trans-Golgi network and endosomes
| Project/Area Number |
19590193
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Fukushima Medical University |
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Principal Investigator |
WAGURI Satoshi Fukushima Medical University, 医学部, 教授 (30244908)
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| Project Period (FY) |
2007 – 2008
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| Project Status |
Completed (Fiscal Year 2008)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | TGN / エンドソーム / 小胞輸送 / クラスリン / GGA / マンノース6リン酸受容体 / mannose 6-phosphate receptor / RNAi / transGolgi Netowork / endosome / トランスゴルジネットワーク / クラスリンアダプター / ライブセルイメージング |
|---|
| Research Abstract |
本課題では、細胞内のトランスゴルジネットワーク(TGN)からエンドソームへの小胞輸送を制御する単量体クラスリンアダプタータンパク質であるGGAsの機能について、ライブセルイメージング法およびRNAi法等を用いて詳細に解析した。その結果、GGAがカーゴタンパク質であるカチオン非依存性マンノース6リン酸受容体のTGNにおける選別過程のみならず、同分子のターンオーバーに関わることを明らかにした。
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation2009
Author(s)
Gotoh K, Lu Z, Morita M, Shibata M, Koike M, Waguri S, Dono K, Doki Y, Kominami E, Sugioka A, Monden M, Uchiyama Y
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Journal Title
Autophagy 5
Pages: 351-360
Related Report
Peer Reviewed
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[Journal Article] The atg8 conjugation system is indispensable for proper development of autophagic isolation membranes in mice2008
Author(s)
Sou YS, Waguri S(equal contribution), Iwata JI, Ueno T, Fujimura T, Hara T, Sawada N, Yamada A, Mizushima N, Uchiyama Y, Kominami E, Tanaka K, Komatsu M
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Journal Title
Mol Biol Cell 19
Pages: 4762-4775
Related Report
Peer Reviewed
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[Journal Article] Human RME-8 is involved in membrane trafficking through early endosome2008
Author(s)
Fujibayashi A, Taguchi T, Misaki R, Ohtani M, Dohmae N, Takio K, Yamada M, Gu J, Yamakami M, Fukuda M, Waguri S, S, Uchiyama Y, Yoshimori T, Sekiguchi K.
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Journal Title
Cell Struct Funct 33
Pages: 35-50
Related Report
Peer Reviewed
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[Journal Article] Inhibition of Autophagy Prevents Hippocampal Pyramidal Neuron Death after Hypoxic-Ischemic Injury2008
Author(s)
Koike M, Shibata M, Tadakoshi M, Gotoh K, Komatsu M, Waguri S, Kawahara N, Kuida K, Nagata S, Kominami E, Tanaka K, Uchiyama Y.
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Journal Title
Am J Pathol 172
Pages: 454-469
Related Report
Peer Reviewed
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[Journal Article] Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice2007
Author(s)
Komatsu M, Waguri S, Koike M, Sou Y, Ueno T, Hara T, Mizushima N, Iwata J, Ezaki J, Murata S, Hamazaki J, Nishito Y, Iemura S, Natsume T, Yanagawa T, Uwayama J, Warabi E, Yoshida H, Ishii T, Kobayashi A, Yamamoto M, Yue Z, Uchiyama Y, Kominami E, Tanaka K
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Journal Title
Cell 131
Pages: 1149-1163
Related Report
Peer Reviewed
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