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Search for the molecular entities of muscarine receptor-operated non-selective cation channels and their regulatory system

Research Project

Project/Area Number 19590202
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionAsahikawa Medical College

Principal Investigator

TAKAI Akira  Asahikawa Medical College, 医学部, 教授 (50126869)

Co-Investigator(Kenkyū-buntansha) YOSHIDA Akitoshi  旭川医科大学, 医学部, 学長 (70125417)
NARUSE Keiji  岡山大学, 医歯(薬)総合研究科, 教授 (40252233)
OHINATA Hiroshi  旭川医科大学, 医学部, 助教 (20233257)
MIYAZU Motoi  旭川医科大学, 医学部, 助教 (40396346)
TAKAI Yoshiko  名古屋大学, 医学部, 講師 (60396356)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords毛様体筋 / ムスカリン受容体 / TRPチャネル / GTP結合蛋白 / 非選択性陽イオンチャネル / 受容体作動性陽イオンチャネル / 非選択性陽イオンヂャネル
Research Abstract

副交感神経支配の効果器の典型である毛様体筋において、受容体作動性非選択性陽イオンチャネル(NSCC)の分子候補としてのTRPC(4種)とOrai1、およびそれらの調節に関与する可能性のある分子としてのG_(q/11)、STIM1、RhoA/kinase、rianodine受容体などの存在と細胞内局在を明らかにした。さらに、それらの機能的意義を検討した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (17 results)

All 2008 2007 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (7 results) Remarks (3 results)

  • [Journal Article] Examination of signalling pathways involved in muscarinic responses in bovine ciliary muscle using YM-254890, an inhibitor of the G_<q/11> protein2008

    • Author(s)
      Yasui F, Miyazu M, Yoshida A, Naruse K & Takai A
    • Journal Title

      Br J Pharmacol 154

      Pages: 890-900

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Protein phosphatase inhibitory activity of tautomycin photoaffinity probes evaluated at femto-molar level2008

    • Author(s)
      Sydnes MO, Kuse M, Kurono M, Shimomura A, Ohinata H, Takai A & Isobe M
    • Journal Title

      Bioorg Med Chem 16

      Pages: 1747-1755

    • Related Report
      2008 Final Research Report 2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Examination of signalling pathways involved in muscarinic responses in bovine ciliary muscle using YM-254890, an inhibitor of the G_(q/11) protein2008

    • Author(s)
      Yasui F, Miyazu M, Yoshida A, Naruse K & Takai A
    • Journal Title

      Br J Pharmacol 154

      Pages: 890-900

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Protein phosphatase inhibitory activity of tautomycin photoaffinity probes evaluated at femto-molar level2008

    • Author(s)
      Sydnes MO, Kuse M, Kurono M, Shimomura A, Ohinata H, Takai A & Isobe M
    • Journal Title

      Biooig Med Chem 16

      Pages: 1747-1755

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Examination of signalling pathways involved in muscarinic responses in bovine ciliary muscle using YM-254890, an inhibitor of the G_<q/11> protein2008

    • Author(s)
      Yasui F, Miyazu M, Yoshida A, Naruse K & Takai A
    • Journal Title

      Br J Pharmacol (印刷中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of [18,19,21,22-^<13>C4]-labeled tautomycin as as NMR probe of protein phosphatase inhibitor2007

    • Author(s)
      Isobe M, Kurono M, Tsuboi K & Takai A
    • Journal Title

      Chemistry Asian J 2

      Pages: 377-385

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of[18,19,21,22^<-13>C4]-labeled tautomycin as as NMR probe of protein phosphatase inhibitor2007

    • Author(s)
      Isobe M, Kurono M, Tsuboi K & Takai A
    • Journal Title

      Chemistry Asian J 2

      Pages: 377-385

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] M_3型ムスカリン受容体の下流に接続する信号伝達機構の分子実体2008

    • Author(s)
      高井章、宮津基、安井文智
    • Organizer
      2008年度・生物物理/分子生物学合同シンポ
    • Place of Presentation
      札幌
    • Year and Date
      2008-11-21
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] 毛様体筋収縮調節にはムスカリン受容体-G_<q/11>下流に接続する複数の分子機構が関与する2008

    • Author(s)
      高井章、宮津基
    • Organizer
      第28回日本眼薬理学会
    • Place of Presentation
      岡山
    • Year and Date
      2008-09-20
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] ウシ毛様体筋の収縮調節に関与する複数のG_<q/11>共役経路2008

    • Author(s)
      高井章、宮津基、安井文智
    • Organizer
      第50回日本平滑筋学会
    • Place of Presentation
      弘前
    • Year and Date
      2008-07-03
    • Related Report
      2008 Final Research Report
  • [Presentation] ウシ毛様体筋の収縮調節に関与する複数のG_<q/11>共役経路2008

    • Author(s)
      高井章、宮津基、安井文智
    • Organizer
      第50回日本平滑筋学会学術集会
    • Place of Presentation
      弘前
    • Year and Date
      2008-07-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Examination of signalling mechanism involved in muscarinic responses of bovine ciliary muscle using a Gq/11-protein inhibitor, YM-2548902008

    • Author(s)
      Yasui F, Miyazu M & Takai A
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-25
    • Related Report
      2008 Final Research Report
  • [Presentation] Examination of signalling mechanism involved in muscarinic responses of bovine ciliary muscle using a G_<q/11>-protein inhibitor, YM-2548902008

    • Author(s)
      Yasui F, Miyazu M & Takai A
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Roles for G_<q/11>-mediated Signaals in the Muscarinic Regulation of Ciliary Muscle Contraction2008

    • Author(s)
      Takai Y, Yasui F, Miyazu M & Takai A
    • Organizer
      The 22^<nd> SICE Symposium on Biological and Physiological Engineering
    • Place of Presentation
      中国、ハルビン市
    • Year and Date
      2008-01-14
    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/phys1/profiles/takai.htm

    • Related Report
      2008 Final Research Report
  • [Remarks]

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/physl/profiles/takai.htm

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.asahikawa-med.ac.jp/dept/mc/phys1/profiles/takai.htm

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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