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Intercellular signaling by changes in the membrane potential of intracellular calcium stores

Research Project

Project/Area Number 19590214
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General physiology
Research InstitutionNara Medical University

Principal Investigator

YAMASHITA Masayuki  Nara Medical University, 医学部, 教授 (20183121)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords細胞生理学 / 細胞内カルシウムストア / カルシウムオシレーション / 膜電位 / 電位感受性蛍光色素 / 共焦点蛍光顕微鏡 / 周波数スペクトラム / 光電子倍増管 / 網膜 / フォトマルチプライア / 細胞内電位記録 / 綱膜
Research Abstract

Synchronous Ca oscillation is caused by releases of Ca from intracellular Ca stores in retinal neuroepithelium. High-speed fluorescence measurement of store membrane potential revealed that periodic repeats of a burst of high-frequency voltage fluctuations occur in the store membrane potential. Electrical coupling across the cells may be mediated by the series capacitance of the store membrane and the plasma membrane.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (21 results)

All 2010 2009 2008

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (12 results)

  • [Journal Article] Synchronization of Ca2+ oscillations: Is gap junctional coupling sufficient2010

    • Author(s)
      Yamashita. M.
    • Journal Title

      FEBS J. 277

      Pages: 277-277

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synchronization of Ca2+ oscillations: a capacitative (AC) electrical coupling model in neuroepithelium.2010

    • Author(s)
      Yamashita, M.
    • Journal Title

      FEBS J. 277

      Pages: 293-299

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synchronization of Ca^<2+> oscillations : Is gap junctional coupling sufficient?2010

    • Author(s)
      Masayuki Yamashita
    • Journal Title

      FEBS Journal VOL.277

      Pages: 277-277

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchronization of Ca^<2+> oscillations : a capacitative(AC)electrical coupling model in neuroepithelium2010

    • Author(s)
      Masayuki Yamashita
    • Journal Title

      FEBS Journal VOL.277

      Pages: 293-299

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Voltage fluctuations of calcium store in retinal neuroepithelium2009

    • Author(s)
      Masayuki Yamashita
    • Journal Title

      Journal of Physiological Sciences VOL.59

      Pages: 149-149

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchronization of calcium oscillation between retinal neuroepithelial cells2009

    • Author(s)
      Masayuki Yamashita
    • Journal Title

      Neuroscience Research VOL.65

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchronous Ca2+ oscillation emerges from voltage fluctuations of Ca2+ stores.2008

    • Author(s)
      Yamashita. M.
    • Journal Title

      FEBS J. 275

      Pages: 4022-4032

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synchronous Ca^<2+> oscillation emerges from voltage fluctuations of Ca^<2+> stores2008

    • Author(s)
      Yamashita Masayuki
    • Journal Title

      FEBS J. 275

      Pages: 4022-4032

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synchronization of calcium oscillation by fluctuations in the membranepotential of calcium store2008

    • Author(s)
      Yamashita Masayuki
    • Journal Title

      The Journal of Physiological Sciences 58 Suppl.

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 網膜神経上皮細胞間におけるカルシウムオシレーションの同期化メカニズム2009

    • Author(s)
      山下勝幸
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-09-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 網膜神経上皮細胞間におけるカルシウムオシレーションの同期化メカニズム2009

    • Author(s)
      山下勝幸
    • Organizer
      第32回日本神経科学大会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2009-09-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] Voltage fluctuations of calcium store in retinal neuroepithelium.2009

    • Author(s)
      Masayuki Yamashita
    • Organizer
      36th International Congress of Physiological Sciences
    • Place of Presentation
      京都
    • Year and Date
      2009-07-28
    • Related Report
      2009 Final Research Report
  • [Presentation] Voltage fluctuations of calcium store in retinal neuroepithelium2009

    • Author(s)
      山下勝幸
    • Organizer
      36^<th> International Congress of Physiological Sciences
    • Place of Presentation
      国立京都国際会館(京都市)
    • Year and Date
      2009-07-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 細胞内カルシウムストアの膜電位とカルシウムオシレーション解剖学・生理学連携シンポジウム"種々の細胞内現象と細胞内小器官に対する形態および機能面からのアプローチ"2009

    • Author(s)
      山下勝幸
    • Organizer
      第114回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-30
    • Related Report
      2009 Final Research Report
  • [Presentation] 発生初期網膜の電気生理学的解析シンポジウム"網膜を材料にした多角的アプローチにより組織細胞の姿を知る"2009

    • Author(s)
      山下勝幸
    • Organizer
      第114回日本解剖学会総会・全国学術集会
    • Place of Presentation
      岡山
    • Year and Date
      2009-03-29
    • Related Report
      2009 Final Research Report
  • [Presentation] 発生初期網膜の電気生理学的解析2009

    • Author(s)
      山下勝幸
    • Organizer
      第114回日本解剖学会総会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] 細胞内カルシウムストアの膜電位とカルシウムオシレーション2009

    • Author(s)
      山下勝幸
    • Organizer
      第114回日本解剖学会総会
    • Place of Presentation
      岡山
    • Related Report
      2008 Annual Research Report
  • [Presentation] Synchronous calcium oscillation emerges from voltage fluctuations of calcium stores.2008

    • Author(s)
      Masayuki Yamashita
    • Organizer
      The 9th International Congress on Cell Biology
    • Place of Presentation
      Seoul
    • Year and Date
      2008-10-09
    • Related Report
      2009 Final Research Report
  • [Presentation] カルシウムストアの膜電位変動によるカルシウムオシレーションの同期化2008

    • Author(s)
      山下勝幸
    • Organizer
      第31回日本神経科学大会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-09
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] カルシウムストアの膜電位変動によるカルシウムオシレーションの同期化2008

    • Author(s)
      山下勝幸
    • Organizer
      第85回日本生理学会大会
    • Place of Presentation
      東京
    • Year and Date
      2008-03-26
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Synchronous calcium oscillation emerges from voltage fluctuations of calcium stores2008

    • Author(s)
      Yamashita Masayuki
    • Organizer
      The 9^<th> International Congress on Cell Biology
    • Place of Presentation
      Seoul
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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