Sex difference in pain response and its mechanism (2)

• Project/Area Number: 19590228
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Yokohama City University
• Principal Investigator: TANAKA Fukuko Yokohama City University, 大学院・医学研究科, 客員教授 (40046066)
• Co-Investigator(Kenkyū-buntansha): FUNABASHI Toshiya 横浜市立大学, 大学院・医学研究科, 准教授 (70229102)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2007: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: ホルマリンテスト / pCREB / 分界条床核 / エストロジェン / ドーパミン / CREB / リン酸化

Research Abstract

分界条床核外側核のCREBの作用をアデノウイルスを用いてdominant negativeに抑制すると、雌性特異的な痛み反応が消失した。A10領域からのドーパミンニューロン投射は性差があり、雌性の方が多いが、分界条床核外側核のドーパミン分泌には性差がなかった。この部位にドーパミン受容体拮抗剤を局所投与すると雌性のみ、痛み反応が増強された。以上の結果から、分界条床核外側核は、雌性特異的な痛み反応に関与していることが推測された

Research Products

• [Journal Article] Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure (2008)
  • Author(s): Tin-Tin-Win-Shwe, Mitsushima D, Yamamoto S, Fukushima A, Funabashi T, Kobayashi T, Fujimaki H.
  • Journal Title: Toxicol Appl Pharmacol 226 Pages: 192-198
• [Journal Article] Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus : simultaneous measurements of the extracellular acethylcholine and serum corticosterone levels in the same subjects (2008)
  • Author(s): Mitsushima D, Takase K, Funabashi T, Kimura F.
  • Journal Title: Endocrinology 149 Pages: 802-811
• [Journal Article] Postpubertal feeding experience affects sex-specific spatial ability in rats (2008)
  • Author(s): Takase K, Mitsushima D, Funabashi T, Kimura
  • Journal Title: Physiol Behav 93 Pages: 553-559
• [Journal Article] 摂食行動の性差と糖代謝 (2008)
  • Author(s): 舩橋利也, 貴邑冨久子
  • Journal Title: Diabetes Front 19 Pages: 454-459
• [Journal Article] Changes in neurotransmitter levels and proinflammatory cytokine mRNA expressions in the mice olfactory bulb following nanoparticle exposure (2008)
  • Author(s): Tin-Tin-Win-Shwe, et al.
  • Journal Title: Toxicol Appl Pharmacol 226 Pages: 192-198
  • Peer Reviewed
• [Journal Article] Gonadal steroid hormones maintain the stress-induced acetylcholine release in the hippocampus : simultaneous measurements of the extracellular acethylcholine and serum corticosterone levels in the same subjects (2008)
  • Author(s): Mitsushima D, et al.
  • Journal Title: Endocrinology 149 Pages: 802-811
  • Peer Reviewed
• [Journal Article] Postpubertal feeding experience affects sex-specific spatial ability in rats (2008)
  • Author(s): Takase K, et al.
  • Journal Title: Physiol Behav 93 Pages: 553-559
  • Peer Reviewed
• [Journal Article] 性差研究の発展のために-ラットおよびヒト脳に関する性差研究の戦略と方法- (2008)
  • Author(s): 貴邑(田中)冨久子, 他
  • Journal Title: 日本臨床 65 Pages: 1135-1145
• [Journal Article] GnRHのパルス状発生器とサージ発生器一多ニューロン発射活動記録法による研究をもとに (2008)
  • Author(s): 貴邑冨久子, 他
  • Journal Title: Horm Front Gynecol 14 Pages: 105-110
• [Journal Article] 摂食行動の性差と糖代謝 (2008)
  • Author(s): 船橋利也, 他
  • Journal Title: Diabetes Front 19 Pages: 454-459
• [Journal Article] Effects of neonatal testosterone treatment on sex differences in formalin-induced nociceptive behavior in rats (2007)
  • Author(s): Hagiwara H, Funabashi T, Mitsushima D, Kimura F.
  • Journal Title: Neurosci Lett 412 Pages: 264-267
  • NAID: 130007038762
• [Journal Article] Sex difference in the 24-h acetylcholine release profile in the premotor/supplementary motor area of behaving rats (2007)
  • Author(s): Takase K, Mitsushima D, Funabashi T, Kimura F.
  • Journal Title: Brain Res 1154 Pages: 105-115
• [Journal Article] Effects of tributyltin on the emotional behavior of C57BL/6 mice and the development of atopic dermatitis-like lesions in DS-Nh mice (2007)
  • Author(s): Ohtaki K, Aihara M, Takahashi H, Fujita H, Takahashi K, Funabashi T, Hirasawa T, Ikezawa Z.
  • Journal Title: J Dermatol Sci 47 Pages: 209-216
  • NAID: 10024116982
• [Journal Article] 性差研究の発展のために-ラットおよびヒト脳に関する性差研究の戦略と方法- (2007)
  • Author(s): 貴邑(田中)冨久子, 舩橋利也, 美津島大
  • Journal Title: 日本臨床 65 Pages: 1135-1145
• [Journal Article] GnRHのパルス状発生器とサージ発生器-多ニューロン発射活動記録法による研究をもとに (2007)
  • Author(s): 貴邑冨久子, 舩橋利也
  • Journal Title: Horm Front Gynecol 14 Pages: 105-110
• [Journal Article] Effects of neonatal testosterone treatment on sex differences in formalin-induced nociceptive behavior in rats (2007)
  • Author(s): Hagiwara H, Funabashi T, Mitsushima D, Kimura F
  • Journal Title: Neurosci Lett 412 Pages: 264-267
  • NAID: 130007038762
  • Peer Reviewed
• [Journal Article] 性差研究の発展のために-ラットおよびヒト脳に関する性差研究の戦略と方法- (2007)
  • Author(s): 貴邑(田中)冨久子, 舩橋利也, 美津島大
  • Journal Title: 日本臨床 65: Pages: 1135-1145
• [Presentation] 摂食行動の性差. 環境ストレスに対する生理応答と性ホルモン (2007)
  • Author(s): 舩橋利也, 貴邑冨久子
  • Organizer: 第84回日本生理学会大会シンポジウム