NMD mediated new stress response mechanism
Project/Area Number |
19590232
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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Research Institution | Tokyo University of Pharmacy and Life Science |
Principal Investigator |
TAKAHASHI Sigeru Tokyo University of Pharmacy and Life Science, 生命科学部, 准教授 (10266900)
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Project Period (FY) |
2007 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 遺伝子 / 栄養学 / 環境 / ストレス / 遺伝子発現 / 転写因子 / ATF5 / 環境応答 / 発現制御 |
Research Abstract |
ATF5 mRNAは通常状態ではuORFからの翻訳によるATF5翻訳領域内でのストップコドンの発生によりNMDによる分解を受けている。一方、ストレス環境下では本来の翻訳開始点からの翻訳が起る事によるNMDシステムからの回避が起り、mRNAの安定性が増加する。その結果、ATF5の発現量が上昇し、標的遺伝子の発現が引き起こされ、ATF5を介したストレス応答が形成されることがわかった。
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Report
(3 results)
Research Products
(16 results)
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[Journal Article] NMR metabolic profiling on highly-diluted neonatal mouse urine2009
Author(s)
Shimizu, Y, I, Sunaga, E., Aoyagi, S., Kanazawa, K., Aul Takahashi, S.AulnoneAstrikeO , Takahashi, Y., and Nemoto, T.
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Journal Title
J. Toxicol. Sci b0 (In Press)
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[Journal Article] Fasting induced up-regulation of activating transcription factor 5 in mouse liver Life Sci2009
Author(s)
Shimizu, Y, I, Morita, M., Ohmi, A., Aoyagi, S., Ebihara, H., Tonaki, D., Horino, Y., Iijima, M., Hirose, H., Aul Takahashi, S. AulnoneAstrike0 and Takahashi, Y.
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Journal Title
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[Journal Article] Stress-induced translation of ATF5 mRNA is regulated by the 5'-untranslated region2008
Author(s)
Watatani, Y., Ichikawa, K., Nakanishi, N., Fujimoto, M., Takeda, H., Kimura, N., Hirose, H., Aul Takahashi, S.AulnoneAstrikeO, Takahashi, Y.
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Journal Title
J. Biol. Chem. b0, 283
Pages: 2543-2553
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[Journal Article] Aminoacid limitation induces expression of ATF5mRNA at post-transcriptional levels2007
Author(s)
Watatani, Y., Kimura, N., Tonaki, D., Hirose, H., Aul Takahashi, S.AulnoneAstrikeO, Takahashi, Y.
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Journal Title
Life Sciences b0, 80
Pages: 879-885
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[Presentation] Upstream open reading frame modulates the NMD-mediated destabilization of ATF5 mRNA in response to cellular stress2007
Author(s)
Takeda,H., Kimura, N., Watatani, Y., Utsugi, K., Ichikawa, K., Uekusa, H., Nakanishi, N., Hirose, H., Takahashi, S., Takahashi, Y.
Organizer
Cold Spring Harbor Laboratory the 2007 meeting on Eukaryotic mRNA Processing.(b0)
Place of Presentation
New York, USA
Year and Date
2007-08-24
Related Report
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[Presentation] Expression of activating transcription factor 5 (ATF5) in cryptic region of mouse intestinal epithelium2007
Author(s)
Aoyagi, S., Morita, M., Nakamura, A., Shimizu, Y.I. Hirose, H., Takahashi, S., Takahashi, Y.
Organizer
FASEB Meeting b0 : Gastrointestinal Tract XII : The Molecular & Integrative Basis for GI Development, Homeostasis & Diseas
Place of Presentation
Colorado, USA
Year and Date
2007-08-11
Related Report