Molecular and cellular mechanisms of fever in brain stroke

• Project/Area Number: 19590234
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Osaka Institute of Technology
• Principal Investigator: MATSUMURA Kiyoshi Osaka Institute of Technology, 情報科学部, 教授 (10157349)
• Co-Investigator(Kenkyū-buntansha): KOBAYASHI Shigeo 京都大学, 大学院情報学研究科, 教授 (40124797) ; HOSOKAWA Hiroshi 京都大学, 大学院情報学研究科, 講師 (90359779)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2007: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 脳出血 / 発熱 / プロスタグランジン / 視索前野 / シクロオキシゲナーゼ / コラゲナーゼ / ラット

Research Abstract

脳出血による発熱の動物モデルを作成し、発熱が起こるしくみを解析した。以下のことが明らかとなった。(1)脳出血による発熱は原因物質(プロスタグランジンE2)が脳内で増加することで引き起こされる。これはウィルス感染による発熱の原因物質と同じである。(2)プロスタグランジンE2 が脳内で増えるしくみは、脳出血の早期と後期で異なる。この研究を発展させると、発熱を伴う脳出血の効果的な治療につながると期待される。

Research Products

• [Journal Article] Intracisternal administration of transforming growth factor-beta evokes fever through the induction of cyclooxygenase-2 in brain endothelial cells (2008)
  • Author(s): Matsumura S, Shibakusa T, Fujikawa T,Yamada H, Matsumura K, Inoue K, Fushiki T
  • Journal Title: Am J Physiol Regul Integr Comp Physiol 294
  • Peer Reviewed
• [Journal Article] Activation of transient receptor potential ankyrin 1 by hydrogenperoxide (2008)
  • Author(s): Sawada Y, Hosokawa H, Matsumura K,Kobayashi S
  • Journal Title: Eur J Neurosci 27
  • Peer Reviewed
• [Journal Article] 疲労神経回路と扁桃体 (2008)
  • Author(s): 松村 潔
  • Journal Title: Clinical Neuroscience 26 Pages: 416-418
• [Journal Article] Intracisternal administration of transforming growth factor-beta evokes fever through the induction of cyclooxygenase-2 in brain endothelial cells (2008)
  • Author(s): Matsumura S, Shibakusa T, Fujikawa T, Yamada H, Matsumura K, Inoue K, Fushiki T
  • Journal Title: Am J Physiol Regul Integr Comp Physiol. 294
  • Peer Reviewed
• [Journal Article] Activation of transient receptor potential ankyrin 1 by hydrogen peroxide. (2008)
  • Author(s): Sawada Y, Hosokawa H, Matsumura K, Kobayashi S
  • Journal Title: Eur J Neurosci. 27 Pages: 1131-42
  • Peer Reviewed
• [Journal Article] 疲労の神経回路と扁桃体 (2008)
  • Author(s): 松村潔
  • Journal Title: Clinical Neuroscience 26 Pages: 416-418
• [Journal Article] Application of menthol to the skin of whole trunk in mice induces autonomic and behavioral heat-gain responses (2007)
  • Author(s): Tajino K, Matsumura K, Kosada K,Shibakusa T, Inoue K, Fushiki T, Hosokawa H, Kobayashi S.
  • Journal Title: Am J Physiol Regul Integr Co mp Physiol 293
  • Peer Reviewed
• [Journal Article] Cold sensitivity of recombinant TRPA1 channels (2007)
  • Author(s): Sawada Y, Hosokawa H, Hori A,Matsumura K, Kobayashi S
  • Journal Title: Brain Res 1160 Pages: 39-46
  • Peer Reviewed
• [Journal Article] Roles of prostaglandin synthesis in excitotoxic brain diseases (2007)
  • Author(s): Takemiya T, Matsumura K, Yamagata K
  • Journal Title: Neurochem Int 51 Pages: 112-20
  • Peer Reviewed
• [Journal Article] Interleukin-6 is a candidate molecule that transmits inflammatory information to the CNS (2007)
  • Author(s): Oka Y, Ibuki T, Matsumura K, Namba M,Yamazaki Y, Poole S, Tanaka Y, Kobayashi S
  • Journal Title: Neuroscience 145 Pages: 530-8
  • Peer Reviewed
• [Presentation] Imaging of lactate utilization in the brain in vitro and in vivo (2008)
  • Author(s): 松村 潔
  • Organizer: International Conference on Fatigue Science 2008
  • Place of Presentation: 沖縄県名護市
  • Year and Date: 2008-09-04
• [Presentation] Imaging of lactate utilization in the brain in vitro and in vivo (2008)
  • Author(s): 松村潔
  • Organizer: Interanational Conference on Fatigue Science 2008
  • Place of Presentation: 沖縄名護市
  • Year and Date: 2008-09-04
• [Presentation] Imaging of lactate utilization in the brain in vitro and in vivo (2008)
  • Author(s): 堀あいこ, 山本知子, 松村潔, 細川浩, 小林茂夫
  • Organizer: Neuroscience 2008
  • Place of Presentation: 東京都千代田区
  • Year and Date: 2008-07-11
• [Presentation] 疲労と発熱の神経・免疫機構 (2008)
  • Author(s): 松村 潔
  • Organizer: 日本生理学会大会
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-25
• [Presentation] ラット脳室内へのアラキドン酸や他の不飽和脂肪酸の投与は脳血管内皮細胞にCOX-2を誘導し発熱を惹起する (2008)
  • Author(s): 堀 あいこ、山本 知子、松村 潔、細川 浩、小林 茂夫
  • Organizer: 日本生理学会大会
  • Place of Presentation: 東京都新宿区
  • Year and Date: 2008-03-25
• [Presentation] リン酸化NFkB は1 次および高次感覚ニューロンの活動マーカーとして利用できる (2007)
  • Author(s): 松村 潔
  • Organizer: Neuro2007
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2007-09-11