Search for longevity genes using nematode, C.elegans and the space environment
| Project/Area Number |
19590238
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
|
|---|
| Research Institution | Tokyo Metropolitan Institute of Gerontology |
|---|
Principal Investigator |
HONDA Yoko Tokyo Metropolitan Institute of Gerontology, 研究員 (90399460)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
HONDA Shuji (財)東京都高齢者研究・福祉振興財団, 主任研究員 (40100127)
|
|---|
| Project Period (FY) |
2007 – 2008
|
| Project Status |
Completed (Fiscal Year 2008)
|
| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | 発達 / 成長 / 老化 / 線虫 / 宇宙実験 / 重力 / 遺伝子発現 / 神経系 / RNA干渉法 / DNAマイクロアレイ / 宇宙 / 環境 / 遺伝子 |
|---|
| Research Abstract |
We studied the effects of inactivation of C.elegans genes that were shown to be downregulated in space by the results of the International C.elegans Experiment (ICE) 1^<st>. We found that RNAi and mutation of 5 genes significantly increased lifespan. These results suggest the possibility that C.elegans ages more slowly in space than on ground.
|
Report
(3 results)
Research Products
(26 results)
-
-
-
-
-
-
[Journal Article] Description of International Caenorhabditis eleans Experiment first flight (ICE-First)2008
Author(s)
Szewczyk N J, Tillman J, Conley C A, Granger L, Segalet L, Higashitani A, Honda S, Honda Y, Kagawa H, Adachi R, Higashibata A, Fujimoto N, Gasset G, Eche B, Chaput D, Viso M
-
Journal Title
Advances in Space Research 42
Pages: 1072-1079
Related Report
Peer Reviewed
-
-
[Journal Article] Description of International Caenorhabditis eleans Experiment first flight (ICE-First)2008
Author(s)
Szewczyk N J, Tillman J, Conley C A, Granger L, Segalet L, Higashitani A, Honda S, Honda Y, Kagawa H, Adachi R, Higashibata A, Fujimoto N, Gasset G. Eche B
-
Journal Title
Advances in Space Research 42
Pages: 1072-1079
Related Report
Peer Reviewed
-
[Journal Article] Biochemical and Molecular Biological Analyses of spaceflown nematodes in Japan, International Caenorhabditis elegans Experiment First (ICE-First)2007
Author(s)
Higashibata A, Higashitani A, Adachi R, Kagawa H, Honda S, Honda Y, Higashitani N, Sasagawa Y, Miyazawa Y, Szewczyk NJ, Connley CA, Fujimoto N, Fukui K, Shimazu T, Kuriyama K, Ishioka N.
-
Journal Title
Microgravity Science and Technology 19
Pages: 159-163
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
[Presentation] 宇宙環境における線虫の老化研究2009
Author(s)
本田陽子, 東端晃, 石岡憲昭, 東谷篤志, 本田修二
Organizer
宇宙利用シンポジウム
Place of Presentation
宇宙航空研究開発機構・宇宙科学研究本部
Year and Date
2009-01-15
Related Report
-
-
-
-
-
-
-
-
-
